Protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues
Introduction: Virgin coconut oil (VCO) is known for its health and therapeutic benefits. However, the immunomodulatory effects of VCO have not been extensively investigated. Objective: The present study was devoted to examining the effects of VCO on cyclophosphamide (CY)-induced toxicity of lympho...
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Kulliyyah of Medicine, International Islamic University Malaysia
2018
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| Online Access: | http://irep.iium.edu.my/68396/ http://irep.iium.edu.my/68396/ http://irep.iium.edu.my/68396/1/68396_Protective%20Effect%20of%20Virgin%20Coconut%20Oil.pdf http://irep.iium.edu.my/68396/7/68396_Protective%20effect%20of%20virgin%20coconut%20oil_scopus.pdf http://irep.iium.edu.my/68396/12/68396%20Protective%20Effect%20of%20Virgin%20Coconut%20Oil%20on%20Cyclophosphamide%20WOS.pdf |
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iium-683962019-01-27T07:04:31Z http://irep.iium.edu.my/68396/ Protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues M. Senin, Mu’izuddin Al-Ani, Imad Matloub Dally Mustafa Mahmoud, Mohammed Imad Al-Deen Muhammad, Naznin Mohd Kasmuri, Mohd Hanif QM Human anatomy QP Physiology RB Pathology Introduction: Virgin coconut oil (VCO) is known for its health and therapeutic benefits. However, the immunomodulatory effects of VCO have not been extensively investigated. Objective: The present study was devoted to examining the effects of VCO on cyclophosphamide (CY)-induced toxicity of lymphoid tissues. Methods: Thirty healthy male Wistar rats were sorted into 5 groups of 6 animals. The first control (NC) group was given distilled water via gavage at 5 ml/kg once daily. The second (CY) group received CY orally at 10 mg/kg/day for 4 weeks. Rats in the other three groups (CV5, CV10, and CV15) were given 10 mg/kg/day CY for 4 weeks, 5 m/kg/day, 10 ml/kg/day and 15 ml/kg/day VCO for 6 weeks, respectively. Rats were sacrificed at the end of 6th week; blood sample from the animals was collected for full blood count and biochemical analysis. The thymus and spleen of each animal was processed for histological examination. Results: The thymus and spleen showed marked reduction in lymphoid cellularity following daily administration of CY. The thymus also showed a marked reduction in the size of the medulla, and the white pulp areas of spleen had reduction in the follicle number and size. Supplementation with 10 ml/kg and 15 ml/kg VCO showed evidence of restoration of both the thymus and splenic lymphoid architecture. The total white cell counts, absolute lymphocyte counts and plasma globulin levels of the VCO groups were significantly increased compared to CY group. Conclusion: VCO displayed potential protective effects on CYinduced histological changes in lymphoid tissues. Kulliyyah of Medicine, International Islamic University Malaysia 2018-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68396/1/68396_Protective%20Effect%20of%20Virgin%20Coconut%20Oil.pdf application/pdf en http://irep.iium.edu.my/68396/7/68396_Protective%20effect%20of%20virgin%20coconut%20oil_scopus.pdf application/pdf en http://irep.iium.edu.my/68396/12/68396%20Protective%20Effect%20of%20Virgin%20Coconut%20Oil%20on%20Cyclophosphamide%20WOS.pdf M. Senin, Mu’izuddin and Al-Ani, Imad Matloub Dally and Mustafa Mahmoud, Mohammed Imad Al-Deen and Muhammad, Naznin and Mohd Kasmuri, Mohd Hanif (2018) Protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues. International Medical Journal Malaysia, 17 (3). pp. 65-74. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_17_no_3/Vol17No3-065.pdf |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English English |
| topic |
QM Human anatomy QP Physiology RB Pathology |
| spellingShingle |
QM Human anatomy QP Physiology RB Pathology M. Senin, Mu’izuddin Al-Ani, Imad Matloub Dally Mustafa Mahmoud, Mohammed Imad Al-Deen Muhammad, Naznin Mohd Kasmuri, Mohd Hanif Protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues |
| description |
Introduction: Virgin coconut oil (VCO) is known for its health and therapeutic benefits. However, the
immunomodulatory effects of VCO have not been extensively investigated. Objective: The present study
was devoted to examining the effects of VCO on cyclophosphamide (CY)-induced toxicity of lymphoid
tissues. Methods: Thirty healthy male Wistar rats were sorted into 5 groups of 6 animals. The first control
(NC) group was given distilled water via gavage at 5 ml/kg once daily. The second (CY) group received CY
orally at 10 mg/kg/day for 4 weeks. Rats in the other three groups (CV5, CV10, and CV15) were given 10
mg/kg/day CY for 4 weeks, 5 m/kg/day, 10 ml/kg/day and 15 ml/kg/day VCO for 6 weeks, respectively.
Rats were sacrificed at the end of 6th week; blood sample from the animals was collected for full blood
count and biochemical analysis. The thymus and spleen of each animal was processed for histological
examination. Results: The thymus and spleen showed marked reduction in lymphoid cellularity following
daily administration of CY. The thymus also showed a marked reduction in the size of the medulla, and the
white pulp areas of spleen had reduction in the follicle number and size. Supplementation with 10 ml/kg
and 15 ml/kg VCO showed evidence of restoration of both the thymus and splenic lymphoid architecture.
The total white cell counts, absolute lymphocyte counts and plasma globulin levels of the VCO groups were
significantly increased compared to CY group. Conclusion: VCO displayed potential protective effects on CYinduced
histological changes in lymphoid tissues. |
| format |
Article |
| author |
M. Senin, Mu’izuddin Al-Ani, Imad Matloub Dally Mustafa Mahmoud, Mohammed Imad Al-Deen Muhammad, Naznin Mohd Kasmuri, Mohd Hanif |
| author_facet |
M. Senin, Mu’izuddin Al-Ani, Imad Matloub Dally Mustafa Mahmoud, Mohammed Imad Al-Deen Muhammad, Naznin Mohd Kasmuri, Mohd Hanif |
| author_sort |
M. Senin, Mu’izuddin |
| title |
Protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues |
| title_short |
Protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues |
| title_full |
Protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues |
| title_fullStr |
Protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues |
| title_full_unstemmed |
Protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues |
| title_sort |
protective effect of virgin coconut oil on cyclophosphamide-induced histological changes in lymphoid tissues |
| publisher |
Kulliyyah of Medicine, International Islamic University Malaysia |
| publishDate |
2018 |
| url |
http://irep.iium.edu.my/68396/ http://irep.iium.edu.my/68396/ http://irep.iium.edu.my/68396/1/68396_Protective%20Effect%20of%20Virgin%20Coconut%20Oil.pdf http://irep.iium.edu.my/68396/7/68396_Protective%20effect%20of%20virgin%20coconut%20oil_scopus.pdf http://irep.iium.edu.my/68396/12/68396%20Protective%20Effect%20of%20Virgin%20Coconut%20Oil%20on%20Cyclophosphamide%20WOS.pdf |
| first_indexed |
2023-09-18T21:37:04Z |
| last_indexed |
2023-09-18T21:37:04Z |
| _version_ |
1777412891463385088 |