Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation

Raloxifene, an estrogen receptor modulator, has poor bioavailability due to extensive metabolism and poor solubility. The present work aimed to enhance skin permeation of raloxifene for systematic delivery. Raloxifene nanoemulsion has been developed using various combination of sunflower oil and tw...

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Main Authors:	Chatterjee, Bappaditya, Mohammed Hasan, Ali Ebrahim
Format:	Conference or Workshop Item
Language:	English English English
Published:	2018
Subjects:	RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/68359/ http://irep.iium.edu.my/68359/1/ICPRP%202018.pdf http://irep.iium.edu.my/68359/13/359%20ICPRP%20PROG%20BOOK.pdf http://irep.iium.edu.my/68359/14/359%20Presentation%20Bappa.pdf

id	iium-68359
recordtype	eprints
spelling	iium-683592018-12-10T06:11:23Z http://irep.iium.edu.my/68359/ Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation Chatterjee, Bappaditya Mohammed Hasan, Ali Ebrahim RS192 Materia Medica-Pharmaceutical Technology Raloxifene, an estrogen receptor modulator, has poor bioavailability due to extensive metabolism and poor solubility. The present work aimed to enhance skin permeation of raloxifene for systematic delivery. Raloxifene nanoemulsion has been developed using various combination of sunflower oil and tween 20- transcutol (surfactant-co-surfactant) followed by the in-vitro characterizations (pH, zeta potential, globule size, thermodynamic stability). Optimized nanoemulsion was converted to nanoemulgel by incorporating carbopol 940 (3% (w/v), pH 6.5) followed by rheology. spreadability, drug loading, toxicity, and ex-vivo permeation studies. Selected formulations resulted in 3.80-3.93 (pH), 24.98-33.8 mV (zeta potential) and 153.10-208.20 nm (globule size) with polydispersity index (<0.259). Developed gel has shown viscoelastic behaviour with acceptable viscosity and spreadability. Drug loading in selected gel, were above 91.41%. Ex-vivo permeation study through rat skin showed significantly higher (>2.5 times) permeation of raloxifene compared to normal gel and solution. FTiR and DSC study revealed alteration of skin fluidity that promotes drug permeation. Nanoemulgel could be a better alternative to deliver raloxifene directly to the circulation through skin due to its nanoscaled size, presence of surfactant and enhanced retention of skin. 2018-10 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/68359/1/ICPRP%202018.pdf application/pdf en http://irep.iium.edu.my/68359/13/359%20ICPRP%20PROG%20BOOK.pdf application/pdf en http://irep.iium.edu.my/68359/14/359%20Presentation%20Bappa.pdf Chatterjee, Bappaditya and Mohammed Hasan, Ali Ebrahim (2018) Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation. In: International Conference on Pharmaceutical Research and Practice, 5th-6th October 2018, Yogjakarta, Indonesia.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology Chatterjee, Bappaditya Mohammed Hasan, Ali Ebrahim Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation
description	Raloxifene, an estrogen receptor modulator, has poor bioavailability due to extensive metabolism and poor solubility. The present work aimed to enhance skin permeation of raloxifene for systematic delivery. Raloxifene nanoemulsion has been developed using various combination of sunflower oil and tween 20- transcutol (surfactant-co-surfactant) followed by the in-vitro characterizations (pH, zeta potential, globule size, thermodynamic stability). Optimized nanoemulsion was converted to nanoemulgel by incorporating carbopol 940 (3% (w/v), pH 6.5) followed by rheology. spreadability, drug loading, toxicity, and ex-vivo permeation studies. Selected formulations resulted in 3.80-3.93 (pH), 24.98-33.8 mV (zeta potential) and 153.10-208.20 nm (globule size) with polydispersity index (<0.259). Developed gel has shown viscoelastic behaviour with acceptable viscosity and spreadability. Drug loading in selected gel, were above 91.41%. Ex-vivo permeation study through rat skin showed significantly higher (>2.5 times) permeation of raloxifene compared to normal gel and solution. FTiR and DSC study revealed alteration of skin fluidity that promotes drug permeation. Nanoemulgel could be a better alternative to deliver raloxifene directly to the circulation through skin due to its nanoscaled size, presence of surfactant and enhanced retention of skin.
format	Conference or Workshop Item
author	Chatterjee, Bappaditya Mohammed Hasan, Ali Ebrahim
author_facet	Chatterjee, Bappaditya Mohammed Hasan, Ali Ebrahim
author_sort	Chatterjee, Bappaditya
title	Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation
title_short	Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation
title_full	Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation
title_fullStr	Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation
title_full_unstemmed	Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation
title_sort	formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation
publishDate	2018
url	http://irep.iium.edu.my/68359/ http://irep.iium.edu.my/68359/1/ICPRP%202018.pdf http://irep.iium.edu.my/68359/13/359%20ICPRP%20PROG%20BOOK.pdf http://irep.iium.edu.my/68359/14/359%20Presentation%20Bappa.pdf
first_indexed	2023-09-18T21:37:01Z
last_indexed	2023-09-18T21:37:01Z
_version_	1777412888861868032

Formulation and in vitro characterization of raloxifene nanoemulgel for improved skin permeation

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