Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts

Clinacanthus nutans (C. nutans) is a local plant belongs to the family Acanthaceae. It is consumed as ‘jamu’ (healthy drink) in Indonesia and as ‘ulam’ in Malaysia. This plant has been claimed for its ability to prevent many diseases including diabetes. However, its scientific proof on this claim is...

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Main Authors:	Murugesu, Suganya, Khatib, Alfi, Ibrahim, Zalikha, Ahmed, Qamar Uddin, Uzir, Bisha Fathamah, Nik Yusoff, Nik Mohd. Idris, Perumal, Vikneswari, Abas, Faridah, Saari, Khozirah
Format:	Article
Language:	English English English
Published:	Universiti Putra Malaysia 2019
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/68289/ http://irep.iium.edu.my/68289/ http://irep.iium.edu.my/68289/1/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus_article.pdf http://irep.iium.edu.my/68289/2/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus_wos.pdf http://irep.iium.edu.my/68289/13/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus%20nutans_scopus.pdf

id	iium-68289
recordtype	eprints
spelling	iium-682892019-08-20T03:54:42Z http://irep.iium.edu.my/68289/ Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts Murugesu, Suganya Khatib, Alfi Ibrahim, Zalikha Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusoff, Nik Mohd. Idris Perumal, Vikneswari Abas, Faridah Saari, Khozirah Q Science (General) Clinacanthus nutans (C. nutans) is a local plant belongs to the family Acanthaceae. It is consumed as ‘jamu’ (healthy drink) in Indonesia and as ‘ulam’ in Malaysia. This plant has been claimed for its ability to prevent many diseases including diabetes. However, its scientific proof on this claim is still lacking. Thus, this study was designed to evaluate the antidiabetic potential and antioxidant capacity of C. nutans leaves extracts using in vitro bioassay tests. The 80% methanolic crude extract of this plant was further partitioned using different polarity solvents viz., hexane, hexane: ethyl acetate (1:1, v/v), ethyl acetate, ethyl acetate: methanol (1:1, v/v) and methanol. All the sub-fractions were analysed for antioxidant effect via 2, 2-diphenyl-2-picrylhydrazil (DPPH) scavenging activity, ferric reducing power (FRAP) and xanthine oxidase (XO) assays followed by antidiabetic evaluation via α-glucosidase and dipeptidyl peptidase-IV (DPP-IV) inhibitory assays and glucose uptake experiment. The ethyl acetate fraction showed a good antioxidant potential while hexane exhibit high α-glucosidase and DPP-IV enzyme inhibition. The hexane fraction also improved glucose uptake in a dose-dependent manner. The study provides an informative data on the potential of C. nutans to be developed as a functional food in preventing diabetes. Universiti Putra Malaysia 2019-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68289/1/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus_article.pdf application/pdf en http://irep.iium.edu.my/68289/2/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus_wos.pdf application/pdf en http://irep.iium.edu.my/68289/13/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus%20nutans_scopus.pdf Murugesu, Suganya and Khatib, Alfi and Ibrahim, Zalikha and Ahmed, Qamar Uddin and Uzir, Bisha Fathamah and Nik Yusoff, Nik Mohd. Idris and Perumal, Vikneswari and Abas, Faridah and Saari, Khozirah (2019) Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts. International Food Research Journal, 26 (1). pp. 319-327. ISSN 1985-4668 E-ISSN 2231-7546 http://www.ifrj.upm.edu.my/26%20(01)%202019/(36).pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	Q Science (General)
spellingShingle	Q Science (General) Murugesu, Suganya Khatib, Alfi Ibrahim, Zalikha Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusoff, Nik Mohd. Idris Perumal, Vikneswari Abas, Faridah Saari, Khozirah Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
description	Clinacanthus nutans (C. nutans) is a local plant belongs to the family Acanthaceae. It is consumed as ‘jamu’ (healthy drink) in Indonesia and as ‘ulam’ in Malaysia. This plant has been claimed for its ability to prevent many diseases including diabetes. However, its scientific proof on this claim is still lacking. Thus, this study was designed to evaluate the antidiabetic potential and antioxidant capacity of C. nutans leaves extracts using in vitro bioassay tests. The 80% methanolic crude extract of this plant was further partitioned using different polarity solvents viz., hexane, hexane: ethyl acetate (1:1, v/v), ethyl acetate, ethyl acetate: methanol (1:1, v/v) and methanol. All the sub-fractions were analysed for antioxidant effect via 2, 2-diphenyl-2-picrylhydrazil (DPPH) scavenging activity, ferric reducing power (FRAP) and xanthine oxidase (XO) assays followed by antidiabetic evaluation via α-glucosidase and dipeptidyl peptidase-IV (DPP-IV) inhibitory assays and glucose uptake experiment. The ethyl acetate fraction showed a good antioxidant potential while hexane exhibit high α-glucosidase and DPP-IV enzyme inhibition. The hexane fraction also improved glucose uptake in a dose-dependent manner. The study provides an informative data on the potential of C. nutans to be developed as a functional food in preventing diabetes.
format	Article
author	Murugesu, Suganya Khatib, Alfi Ibrahim, Zalikha Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusoff, Nik Mohd. Idris Perumal, Vikneswari Abas, Faridah Saari, Khozirah
author_facet	Murugesu, Suganya Khatib, Alfi Ibrahim, Zalikha Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusoff, Nik Mohd. Idris Perumal, Vikneswari Abas, Faridah Saari, Khozirah
author_sort	Murugesu, Suganya
title	Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
title_short	Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
title_full	Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
title_fullStr	Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
title_full_unstemmed	Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
title_sort	antidiabetic and antioxidants activities of clinacanthus nutans (burm f.) lindau leaves extracts
publisher	Universiti Putra Malaysia
publishDate	2019
url	http://irep.iium.edu.my/68289/ http://irep.iium.edu.my/68289/ http://irep.iium.edu.my/68289/1/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus_article.pdf http://irep.iium.edu.my/68289/2/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus_wos.pdf http://irep.iium.edu.my/68289/13/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus%20nutans_scopus.pdf
first_indexed	2023-09-18T21:36:54Z
last_indexed	2023-09-18T21:36:54Z
_version_	1777412881714774016

Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts

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