Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
Clinacanthus nutans (C. nutans) is a local plant belongs to the family Acanthaceae. It is consumed as ‘jamu’ (healthy drink) in Indonesia and as ‘ulam’ in Malaysia. This plant has been claimed for its ability to prevent many diseases including diabetes. However, its scientific proof on this claim is...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Universiti Putra Malaysia
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/68289/ http://irep.iium.edu.my/68289/ http://irep.iium.edu.my/68289/1/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus_article.pdf http://irep.iium.edu.my/68289/2/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus_wos.pdf http://irep.iium.edu.my/68289/13/68289_Antidiabetic%20and%20antioxidants%20activities%20of%20Clinacanthus%20nutans_scopus.pdf |
| Summary: | Clinacanthus nutans (C. nutans) is a local plant belongs to the family Acanthaceae. It is consumed as ‘jamu’ (healthy drink) in Indonesia and as ‘ulam’ in Malaysia. This plant has been claimed for its ability to prevent many diseases including diabetes. However, its scientific proof on this claim is still lacking. Thus, this study was designed to evaluate the antidiabetic potential and antioxidant capacity of C. nutans leaves extracts using in vitro bioassay tests. The 80% methanolic crude extract of this plant was further partitioned using different polarity solvents viz., hexane, hexane: ethyl acetate (1:1, v/v), ethyl acetate, ethyl acetate: methanol (1:1, v/v) and methanol. All the sub-fractions were analysed for antioxidant effect via 2, 2-diphenyl-2-picrylhydrazil (DPPH) scavenging activity, ferric reducing power (FRAP) and xanthine oxidase (XO) assays followed by antidiabetic evaluation via α-glucosidase and dipeptidyl peptidase-IV (DPP-IV) inhibitory assays and glucose uptake experiment. The ethyl acetate fraction showed a good antioxidant potential while hexane exhibit high α-glucosidase and DPP-IV enzyme inhibition. The hexane fraction also improved glucose uptake in a dose-dependent manner. The study provides an informative data on the potential of C. nutans to be developed as a functional food in preventing diabetes. |
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