Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA

The effects of poly(lactic‑co‑glycolic acid) (PLGA) on structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds have been studied comprehensively. The porous structure of the iron has been incorporated with the curcumin-loaded PLGA (CP) partic...

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Main Authors:	Yusop, Abdul Hakim, Sarian, Murni Nazira, Januddi, Fatihhi Szali, Ahmed, Qamar Uddin, Kadir, Mohammed Rafiq, Hartanto, Djoko, Hermawan, Hendra, Nur, Hadi
Format:	Article
Language:	English English English
Published:	Elsevier 2018
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/67839/ http://irep.iium.edu.my/67839/ http://irep.iium.edu.my/67839/ http://irep.iium.edu.my/67839/7/67839%20Structure%2C%20degradation%2C%20drug%20release%20and%20mechanical%20properties.pdf http://irep.iium.edu.my/67839/8/67839%20Structure%2C%20degradation%2C%20drug%20release%20and%20mechanical%20properties%20SCOPUS.pdf http://irep.iium.edu.my/67839/19/67839%20Structure%2C%20degradation%2C%20drug%20release%20WOS.pdf

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spelling	iium-678392019-01-27T06:47:36Z http://irep.iium.edu.my/67839/ Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA Yusop, Abdul Hakim Sarian, Murni Nazira Januddi, Fatihhi Szali Ahmed, Qamar Uddin Kadir, Mohammed Rafiq Hartanto, Djoko Hermawan, Hendra Nur, Hadi Q Science (General) The effects of poly(lactic‑co‑glycolic acid) (PLGA) on structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds have been studied comprehensively. The porous structure of the iron has been incorporated with the curcumin-loaded PLGA (CP) particles through dipping method to produce CP-coated porous Fe (CP-Fe). The CP-Fe degradation has been escalated with the increase of PLGA composition due to the hydrolysis of PLGA. The degradation of iron substrate triggered the kinetics of curcumin release as there was a direct correlation between the curcumin release rate and the degradation rate of the CP-Fe scaffold. The stiffness of the CP particles and the interfacial interactions developed between the CP coating and iron surface have enhanced scaffolds' mechanical strengths. The curcumin released from the scaffold significantly arrested osteosarcoma cells growth. It is demonstrated that the PLGA played an important role to control the scaffold degradation and curcumin release as well as enhancing the mechanical properties of the drug device as an integrated system for favorable scaffold-based drug design. Elsevier 2018-12-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/67839/7/67839%20Structure%2C%20degradation%2C%20drug%20release%20and%20mechanical%20properties.pdf application/pdf en http://irep.iium.edu.my/67839/8/67839%20Structure%2C%20degradation%2C%20drug%20release%20and%20mechanical%20properties%20SCOPUS.pdf application/pdf en http://irep.iium.edu.my/67839/19/67839%20Structure%2C%20degradation%2C%20drug%20release%20WOS.pdf Yusop, Abdul Hakim and Sarian, Murni Nazira and Januddi, Fatihhi Szali and Ahmed, Qamar Uddin and Kadir, Mohammed Rafiq and Hartanto, Djoko and Hermawan, Hendra and Nur, Hadi (2018) Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA. Materials & Design, 160. pp. 203-217. ISSN 0264-1275 https://ac.els-cdn.com/S0264127518307172/1-s2.0-S0264127518307172-main.pdf?_tid=212a8d7f-c68a-4262-a298-6b3b96c59943&acdnat=1543478809_8d48c91136e0ff23945ea5b14f6e446e 10.1016/j.matdes.2018.09.019
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	Q Science (General)
spellingShingle	Q Science (General) Yusop, Abdul Hakim Sarian, Murni Nazira Januddi, Fatihhi Szali Ahmed, Qamar Uddin Kadir, Mohammed Rafiq Hartanto, Djoko Hermawan, Hendra Nur, Hadi Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA
description	The effects of poly(lactic‑co‑glycolic acid) (PLGA) on structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds have been studied comprehensively. The porous structure of the iron has been incorporated with the curcumin-loaded PLGA (CP) particles through dipping method to produce CP-coated porous Fe (CP-Fe). The CP-Fe degradation has been escalated with the increase of PLGA composition due to the hydrolysis of PLGA. The degradation of iron substrate triggered the kinetics of curcumin release as there was a direct correlation between the curcumin release rate and the degradation rate of the CP-Fe scaffold. The stiffness of the CP particles and the interfacial interactions developed between the CP coating and iron surface have enhanced scaffolds' mechanical strengths. The curcumin released from the scaffold significantly arrested osteosarcoma cells growth. It is demonstrated that the PLGA played an important role to control the scaffold degradation and curcumin release as well as enhancing the mechanical properties of the drug device as an integrated system for favorable scaffold-based drug design.
format	Article
author	Yusop, Abdul Hakim Sarian, Murni Nazira Januddi, Fatihhi Szali Ahmed, Qamar Uddin Kadir, Mohammed Rafiq Hartanto, Djoko Hermawan, Hendra Nur, Hadi
author_facet	Yusop, Abdul Hakim Sarian, Murni Nazira Januddi, Fatihhi Szali Ahmed, Qamar Uddin Kadir, Mohammed Rafiq Hartanto, Djoko Hermawan, Hendra Nur, Hadi
author_sort	Yusop, Abdul Hakim
title	Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA
title_short	Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA
title_full	Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA
title_fullStr	Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA
title_full_unstemmed	Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA
title_sort	structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: the effects of plga
publisher	Elsevier
publishDate	2018
url	http://irep.iium.edu.my/67839/ http://irep.iium.edu.my/67839/ http://irep.iium.edu.my/67839/ http://irep.iium.edu.my/67839/7/67839%20Structure%2C%20degradation%2C%20drug%20release%20and%20mechanical%20properties.pdf http://irep.iium.edu.my/67839/8/67839%20Structure%2C%20degradation%2C%20drug%20release%20and%20mechanical%20properties%20SCOPUS.pdf http://irep.iium.edu.my/67839/19/67839%20Structure%2C%20degradation%2C%20drug%20release%20WOS.pdf
first_indexed	2023-09-18T21:36:19Z
last_indexed	2023-09-18T21:36:19Z
_version_	1777412844864667648

Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA

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