Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves

Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting the...

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Main Authors:	Wan Ahmad, Wan Nadilah, Shaari, Khozirah, Khatib, Alfi, Abdul Hamid, Azizah, Hamid, Muhajir
Format:	Article
Language:	English English
Published:	Universiti Pertanian Malaysia 2018
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/67695/ http://irep.iium.edu.my/67695/ http://irep.iium.edu.my/67695/1/wan%20ahmad%20et%20al%202018%20Pertanika.pdf http://irep.iium.edu.my/67695/7/67695_Chemical%20profile%2C%20total%20phenolic%20content_scopus.pdf

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recordtype	eprints
spelling	iium-676952018-11-27T09:09:32Z http://irep.iium.edu.my/67695/ Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves Wan Ahmad, Wan Nadilah Shaari, Khozirah Khatib, Alfi Abdul Hamid, Azizah Hamid, Muhajir RS403 Materia Medica-Pharmaceutical Chemistry Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting the enzyme α-glucosidase. In addition, their metabolite profiles were also characterized using liquid chromatography–mass spectrometry. The bioactivity was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-xyloside, quercetin 3-O-arabinofuranoside, quercetin 3-O-rhamnoside, and quercetin 3-O-galactoside, as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering effects of C. caudatus leaves. The results indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents. Universiti Pertanian Malaysia 2018-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/67695/1/wan%20ahmad%20et%20al%202018%20Pertanika.pdf application/pdf en http://irep.iium.edu.my/67695/7/67695_Chemical%20profile%2C%20total%20phenolic%20content_scopus.pdf Wan Ahmad, Wan Nadilah and Shaari, Khozirah and Khatib, Alfi and Abdul Hamid, Azizah and Hamid, Muhajir (2018) Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves. Pertanika Journal of Tropical Agricultural Science, 41 (3). pp. 1367-1381. ISSN 1511-3701 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2041%20(3)%20Aug.%202018/32%20JTAS%201327-2018.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS403 Materia Medica-Pharmaceutical Chemistry Wan Ahmad, Wan Nadilah Shaari, Khozirah Khatib, Alfi Abdul Hamid, Azizah Hamid, Muhajir Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves
description	Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting the enzyme α-glucosidase. In addition, their metabolite profiles were also characterized using liquid chromatography–mass spectrometry. The bioactivity was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-xyloside, quercetin 3-O-arabinofuranoside, quercetin 3-O-rhamnoside, and quercetin 3-O-galactoside, as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering effects of C. caudatus leaves. The results indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents.
format	Article
author	Wan Ahmad, Wan Nadilah Shaari, Khozirah Khatib, Alfi Abdul Hamid, Azizah Hamid, Muhajir
author_facet	Wan Ahmad, Wan Nadilah Shaari, Khozirah Khatib, Alfi Abdul Hamid, Azizah Hamid, Muhajir
author_sort	Wan Ahmad, Wan Nadilah
title	Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves
title_short	Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves
title_full	Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves
title_fullStr	Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves
title_full_unstemmed	Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves
title_sort	chemical profile, total phenolic content, dpph free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves
publisher	Universiti Pertanian Malaysia
publishDate	2018
url	http://irep.iium.edu.my/67695/ http://irep.iium.edu.my/67695/ http://irep.iium.edu.my/67695/1/wan%20ahmad%20et%20al%202018%20Pertanika.pdf http://irep.iium.edu.my/67695/7/67695_Chemical%20profile%2C%20total%20phenolic%20content_scopus.pdf
first_indexed	2023-09-18T21:36:05Z
last_indexed	2023-09-18T21:36:05Z
_version_	1777412829849059328

Chemical profile, total phenolic content, DPPH free radical scavenging and α-glucosidase inhibitory activities of cosmos caudatus kunth leaves

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