$Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions$

Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions

The fruit of Dialium indum L. (Fabaceae) is one of the edible wild fruits native to Southeast Asia. The mesocarp is consumed as sweets while the exocarp and seed are regarded as waste. This study aimed to evaluate the antioxidant activities of the fruit by using four assays, which measure its capabi...

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Main Authors:	Osman, Muhamad Faris, Mohd Hassan, Norazian, Khatib, Alfi, Tolos, Siti Marponga
Format:	Article
Language:	English English English
Published:	Multidisciplinary Digital Publishing Institute (MDPI) 2018
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/67382/ http://irep.iium.edu.my/67382/ http://irep.iium.edu.my/67382/ http://irep.iium.edu.my/67382/1/67382_Antioxidant%20activities%20of%20Dialium%20indum%20L.%20fruit.pdf http://irep.iium.edu.my/67382/2/67382_Antioxidant%20activities%20of%20Dialium%20indum%20L.%20fruit_SCOPUS.pdf http://irep.iium.edu.my/67382/13/67382_Antioxidant%20activities%20of%20Dialium%20indum%20L.%20fruit_WOS.pdf

id	iium-67382
recordtype	eprints
spelling	iium-673822018-12-31T12:37:46Z http://irep.iium.edu.my/67382/ Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions Osman, Muhamad Faris Mohd Hassan, Norazian Khatib, Alfi Tolos, Siti Marponga RS403 Materia Medica-Pharmaceutical Chemistry The fruit of Dialium indum L. (Fabaceae) is one of the edible wild fruits native to Southeast Asia. The mesocarp is consumed as sweets while the exocarp and seed are regarded as waste. This study aimed to evaluate the antioxidant activities of the fruit by using four assays, which measure its capabilities in reducing phosphomolybdic-phosphotungstic acid reagents, neocuproine, 2,2-diphenyl-picrylhydrazyl (DPPH), and inhibiting linoleic acid peroxidation. The active fractions were then analyzed by gas chromatography-mass spectrometry (GC-MS). The results showed that the seed methanol fraction (SMF) exhibited the strongest antioxidant activity with significantly higher (p < 0.05) gallic acid equivalence (GAE), total antioxidant capacity (TAC), and DPPH radical scavenging activity (IC50 31.71; 0.88 μg/mL) than the other fractions. The exocarp dichloromethane fraction (EDF) was the discriminating fraction by having remarkable linoleic acid peroxidation inhibition (IC50 121.43; 2.97 μg/mL). A total of thirty-eight metabolites were detected in derivatized EDF and SMF with distinctive classes of phenolics and amino acids, respectively. Bioautography-guided fractionation of EDF afforded five antioxidant-enriched subfractions with four other detected phenolics. The results revealed the antioxidant properties of D. indum fruit, which has potential benefits in pharmaceutical, nutraceutical, and cosmeceutical applications. Multidisciplinary Digital Publishing Institute (MDPI) 2018-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/67382/1/67382_Antioxidant%20activities%20of%20Dialium%20indum%20L.%20fruit.pdf application/pdf en http://irep.iium.edu.my/67382/2/67382_Antioxidant%20activities%20of%20Dialium%20indum%20L.%20fruit_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/67382/13/67382_Antioxidant%20activities%20of%20Dialium%20indum%20L.%20fruit_WOS.pdf Osman, Muhamad Faris and Mohd Hassan, Norazian and Khatib, Alfi and Tolos, Siti Marponga (2018) Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions. Antioxidants, 7 (11). pp. 1-14. ISSN 2076-3921 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262551/ 10.3390/antiox7110154
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS403 Materia Medica-Pharmaceutical Chemistry Osman, Muhamad Faris Mohd Hassan, Norazian Khatib, Alfi Tolos, Siti Marponga Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions
description	The fruit of Dialium indum L. (Fabaceae) is one of the edible wild fruits native to Southeast Asia. The mesocarp is consumed as sweets while the exocarp and seed are regarded as waste. This study aimed to evaluate the antioxidant activities of the fruit by using four assays, which measure its capabilities in reducing phosphomolybdic-phosphotungstic acid reagents, neocuproine, 2,2-diphenyl-picrylhydrazyl (DPPH), and inhibiting linoleic acid peroxidation. The active fractions were then analyzed by gas chromatography-mass spectrometry (GC-MS). The results showed that the seed methanol fraction (SMF) exhibited the strongest antioxidant activity with significantly higher (p < 0.05) gallic acid equivalence (GAE), total antioxidant capacity (TAC), and DPPH radical scavenging activity (IC50 31.71; 0.88 μg/mL) than the other fractions. The exocarp dichloromethane fraction (EDF) was the discriminating fraction by having remarkable linoleic acid peroxidation inhibition (IC50 121.43; 2.97 μg/mL). A total of thirty-eight metabolites were detected in derivatized EDF and SMF with distinctive classes of phenolics and amino acids, respectively. Bioautography-guided fractionation of EDF afforded five antioxidant-enriched subfractions with four other detected phenolics. The results revealed the antioxidant properties of D. indum fruit, which has potential benefits in pharmaceutical, nutraceutical, and cosmeceutical applications.
format	Article
author	Osman, Muhamad Faris Mohd Hassan, Norazian Khatib, Alfi Tolos, Siti Marponga
author_facet	Osman, Muhamad Faris Mohd Hassan, Norazian Khatib, Alfi Tolos, Siti Marponga
author_sort	Osman, Muhamad Faris
title	Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions
title_short	Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions
title_full	Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions
title_fullStr	Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions
title_full_unstemmed	Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions
title_sort	antioxidant activities of dialium indum l. fruit and gas chromatography-mass spectrometry (gc-ms) of the active fractions
publisher	Multidisciplinary Digital Publishing Institute (MDPI)
publishDate	2018
url	http://irep.iium.edu.my/67382/ http://irep.iium.edu.my/67382/ http://irep.iium.edu.my/67382/ http://irep.iium.edu.my/67382/1/67382_Antioxidant%20activities%20of%20Dialium%20indum%20L.%20fruit.pdf http://irep.iium.edu.my/67382/2/67382_Antioxidant%20activities%20of%20Dialium%20indum%20L.%20fruit_SCOPUS.pdf http://irep.iium.edu.my/67382/13/67382_Antioxidant%20activities%20of%20Dialium%20indum%20L.%20fruit_WOS.pdf
first_indexed	2023-09-18T21:35:40Z
last_indexed	2023-09-18T21:35:40Z
_version_	1777412804130635776

Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions

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