Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study

Introduction: Presence of scattered gamma photons in the projection data of Tc-99m Myocardial SPECT degrades the image quality. Thus, the efficacy of SPECT in patient studies is hampered. This work is aimed at enhancing the image quality and accuracy in measurement of cold defect size by pre-filteri...

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Main Authors:	Sayed, Inayatullah Shah, Mohd Zulkele, Nurul Farizan, Che Daud, Mohd. Zamzuri, Abdul Rahim, Mohamad Shahrir
Format:	Conference or Workshop Item
Language:	English English
Published:	2017
Subjects:	QC Physics
Online Access:	http://irep.iium.edu.my/67342/ http://irep.iium.edu.my/67342/1/7thGNM_Abstract_Sayed.pdf http://irep.iium.edu.my/67342/7/Abstract%20_Acceptance%20Letter.pdf

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spelling	iium-673422018-11-27T01:36:38Z http://irep.iium.edu.my/67342/ Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study Sayed, Inayatullah Shah Mohd Zulkele, Nurul Farizan Che Daud, Mohd. Zamzuri Abdul Rahim, Mohamad Shahrir QC Physics Introduction: Presence of scattered gamma photons in the projection data of Tc-99m Myocardial SPECT degrades the image quality. Thus, the efficacy of SPECT in patient studies is hampered. This work is aimed at enhancing the image quality and accuracy in measurement of cold defect size by pre-filtering of scattered gamma photons with physical filter. Material and method: GE Infinia II gamma camera with LEHR collimator was used. A flat sheet of Aluminum 0.1 mm thick, 55 cm x 44 cm sized was mounted on the outer surface of collimator. Carlson’s phantom with cardiac insert simulating the left ventricle was scanned. A polystyrene cold defect (9.8 mm x 9.8 mm x 9.8 mm) was placed at the anterior side of the myocardial wall. Water was filled into myocardial wall chamber; Tc-99m with concentration of 3.9μCi/ml was injected. It was inserted into the cylindrical tank after water was filled. Tc-99m radioactivity with 1.1μCi/ml concentration as background was administered. The chamber was positioned according to the orientation of human heart. Energy window (20%) centred at 140 keV was adjusted. Data were registered into a 128x128 matrix with sixty projections with and without physical filter opting step-and-shoot acquisition extended in a 180o arc from 45˚ right anterior oblique to 45˚ left posterior oblique. Filtered back projection method was used for image reconstruction by selecting Butterworth filter of order 10 and cut-off frequency 0.40/cm. Chang’s attenuation correction was applied. Results: Cold defect size measurement and image contour analysis of short axis views show significant improvement (p<0.05) in the accuracy in defect size and image quality with physical filter. Our study demonstrates that this technique is effective in removing scattered gamma photons from SPECT projection data. Conclusion: Physical filter technique may be implemented in Tc-99m myocardial SPECT clinical studies. Yet still, further studies are required with different phantoms which mimic the human heart closely. 2017-12-09 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/67342/1/7thGNM_Abstract_Sayed.pdf application/pdf en http://irep.iium.edu.my/67342/7/Abstract%20_Acceptance%20Letter.pdf Sayed, Inayatullah Shah and Mohd Zulkele, Nurul Farizan and Che Daud, Mohd. Zamzuri and Abdul Rahim, Mohamad Shahrir (2017) Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study. In: 7th Gulf Nuclear Medicine Conference 2017, 9th-12th December 2017, Muscat, Oman. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QC Physics
spellingShingle	QC Physics Sayed, Inayatullah Shah Mohd Zulkele, Nurul Farizan Che Daud, Mohd. Zamzuri Abdul Rahim, Mohamad Shahrir Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study
description	Introduction: Presence of scattered gamma photons in the projection data of Tc-99m Myocardial SPECT degrades the image quality. Thus, the efficacy of SPECT in patient studies is hampered. This work is aimed at enhancing the image quality and accuracy in measurement of cold defect size by pre-filtering of scattered gamma photons with physical filter. Material and method: GE Infinia II gamma camera with LEHR collimator was used. A flat sheet of Aluminum 0.1 mm thick, 55 cm x 44 cm sized was mounted on the outer surface of collimator. Carlson’s phantom with cardiac insert simulating the left ventricle was scanned. A polystyrene cold defect (9.8 mm x 9.8 mm x 9.8 mm) was placed at the anterior side of the myocardial wall. Water was filled into myocardial wall chamber; Tc-99m with concentration of 3.9μCi/ml was injected. It was inserted into the cylindrical tank after water was filled. Tc-99m radioactivity with 1.1μCi/ml concentration as background was administered. The chamber was positioned according to the orientation of human heart. Energy window (20%) centred at 140 keV was adjusted. Data were registered into a 128x128 matrix with sixty projections with and without physical filter opting step-and-shoot acquisition extended in a 180o arc from 45˚ right anterior oblique to 45˚ left posterior oblique. Filtered back projection method was used for image reconstruction by selecting Butterworth filter of order 10 and cut-off frequency 0.40/cm. Chang’s attenuation correction was applied. Results: Cold defect size measurement and image contour analysis of short axis views show significant improvement (p<0.05) in the accuracy in defect size and image quality with physical filter. Our study demonstrates that this technique is effective in removing scattered gamma photons from SPECT projection data. Conclusion: Physical filter technique may be implemented in Tc-99m myocardial SPECT clinical studies. Yet still, further studies are required with different phantoms which mimic the human heart closely.
format	Conference or Workshop Item
author	Sayed, Inayatullah Shah Mohd Zulkele, Nurul Farizan Che Daud, Mohd. Zamzuri Abdul Rahim, Mohamad Shahrir
author_facet	Sayed, Inayatullah Shah Mohd Zulkele, Nurul Farizan Che Daud, Mohd. Zamzuri Abdul Rahim, Mohamad Shahrir
author_sort	Sayed, Inayatullah Shah
title	Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study
title_short	Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study
title_full	Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study
title_fullStr	Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study
title_full_unstemmed	Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study
title_sort	tc-99m myocardial spect image quality improvement with a physical filter as scattered gamma photon absorber: phantom study
publishDate	2017
url	http://irep.iium.edu.my/67342/ http://irep.iium.edu.my/67342/1/7thGNM_Abstract_Sayed.pdf http://irep.iium.edu.my/67342/7/Abstract%20_Acceptance%20Letter.pdf
first_indexed	2023-09-18T21:35:38Z
last_indexed	2023-09-18T21:35:38Z
_version_	1777412801184137216

Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study

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