Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities

The study on small molecule of heterocyclic incorporated with nitrogen and sulfur have been widely explored in term of their synthetic and biological applications. Heterocyclic thiazole emerges as one of the most frequently reported in those field. Since thiazole moiety seems to be possible candidat...

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Main Authors:	Ngah, Nurziana, Darnis, Deny Susanti, Abd Hamid, Shafida, Jumal, Juliana, Abdullah Ripain, Iswatun Hasanah
Format:	Monograph
Language:	English
Published:	2018
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/67278/ http://irep.iium.edu.my/67278/1/Progress%20Report%20.pdf

id	iium-67278
recordtype	eprints
spelling	iium-672782018-11-08T02:45:32Z http://irep.iium.edu.my/67278/ Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities Ngah, Nurziana Darnis, Deny Susanti Abd Hamid, Shafida Jumal, Juliana Abdullah Ripain, Iswatun Hasanah QD Chemistry The study on small molecule of heterocyclic incorporated with nitrogen and sulfur have been widely explored in term of their synthetic and biological applications. Heterocyclic thiazole emerges as one of the most frequently reported in those field. Since thiazole moiety seems to be possible candidate in various biologically active agents, we developed several new thiazole derivatives by the reaction of haloketone, ammonium thiocyanate and selected amines which give corresponding thiazole derivatives in excellent yields. The chemical structures of the resulting products were confirmed by means of 1H NMR, IR, UV-Vis and GCMS. These compounds were screened for antibacterial properties against Gram-positive bacterial strains namely Bacillus cereus, Staphylococcus epidermidis as well as Gram-negative bacterial strains such as Escherichia coli and Pseudomonas aeruginosa using disc diffusion method. Molecular docking was also performed against Glucosamine-6-phosphate (GlcN-6-P) synthase which is known as the essential building block of most bacteria in order to know the detailed mechanism. 2018-10-31 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/67278/1/Progress%20Report%20.pdf Ngah, Nurziana and Darnis, Deny Susanti and Abd Hamid, Shafida and Jumal, Juliana and Abdullah Ripain, Iswatun Hasanah (2018) Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities. Research Report. UNSPECIFIED. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Ngah, Nurziana Darnis, Deny Susanti Abd Hamid, Shafida Jumal, Juliana Abdullah Ripain, Iswatun Hasanah Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities
description	The study on small molecule of heterocyclic incorporated with nitrogen and sulfur have been widely explored in term of their synthetic and biological applications. Heterocyclic thiazole emerges as one of the most frequently reported in those field. Since thiazole moiety seems to be possible candidate in various biologically active agents, we developed several new thiazole derivatives by the reaction of haloketone, ammonium thiocyanate and selected amines which give corresponding thiazole derivatives in excellent yields. The chemical structures of the resulting products were confirmed by means of 1H NMR, IR, UV-Vis and GCMS. These compounds were screened for antibacterial properties against Gram-positive bacterial strains namely Bacillus cereus, Staphylococcus epidermidis as well as Gram-negative bacterial strains such as Escherichia coli and Pseudomonas aeruginosa using disc diffusion method. Molecular docking was also performed against Glucosamine-6-phosphate (GlcN-6-P) synthase which is known as the essential building block of most bacteria in order to know the detailed mechanism.
format	Monograph
author	Ngah, Nurziana Darnis, Deny Susanti Abd Hamid, Shafida Jumal, Juliana Abdullah Ripain, Iswatun Hasanah
author_facet	Ngah, Nurziana Darnis, Deny Susanti Abd Hamid, Shafida Jumal, Juliana Abdullah Ripain, Iswatun Hasanah
author_sort	Ngah, Nurziana
title	Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities
title_short	Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities
title_full	Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities
title_fullStr	Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities
title_full_unstemmed	Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities
title_sort	design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities
publishDate	2018
url	http://irep.iium.edu.my/67278/ http://irep.iium.edu.my/67278/1/Progress%20Report%20.pdf
first_indexed	2023-09-18T21:35:32Z
last_indexed	2023-09-18T21:35:32Z
_version_	1777412795615150080

Design, synthesis and characterization of 2,4-disubstituted-1,3 thiazole amino acid derivatives towards its applications on antimicrobial and antioxidant activities

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