Marine animals and snakes: their venoms and poisons for therapeutics

The discovery and modification of angiotensin converting enzyme inhibitor. Angiotensin converting enzyme inhibitor creation starts when Bothrops jararaca venom was found to be causing hypotension by potentiating-bradykinin activity. Bradykinin-potentiating peptides are also found in Viperidea and El...

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Main Authors:	Othman, Iekhsan, Zainal Abidin, Syafiq Asnawi, Abdullah, Nur Atiqah, Shaikh, Mohd Farooq, Ismail, Ahmad Khaldun, Ahmad Rusmili, Muhamad Rusdi, Naidu, Rakesh
Format:	Conference or Workshop Item
Language:	English
Published:	2018
Subjects:	RA Public aspects of medicine RA644.3 Public Health. Hygiene. Preventive Medicine - Chronic and Noninfectious Diseases and Public Health RM Therapeutics. Pharmacology RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/67157/ http://irep.iium.edu.my/67157/ http://irep.iium.edu.my/67157/1/67157_MARINE%20ANIMALS%20AND%20SNAKES-%20abstract.pdf

id	iium-67157
recordtype	eprints
spelling	iium-671572018-10-31T02:13:53Z http://irep.iium.edu.my/67157/ Marine animals and snakes: their venoms and poisons for therapeutics Othman, Iekhsan Zainal Abidin, Syafiq Asnawi Abdullah, Nur Atiqah Shaikh, Mohd Farooq Ismail, Ahmad Khaldun Ahmad Rusmili, Muhamad Rusdi Naidu, Rakesh RA Public aspects of medicine RA644.3 Public Health. Hygiene. Preventive Medicine - Chronic and Noninfectious Diseases and Public Health RM Therapeutics. Pharmacology RM300 Drugs and their action The discovery and modification of angiotensin converting enzyme inhibitor. Angiotensin converting enzyme inhibitor creation starts when Bothrops jararaca venom was found to be causing hypotension by potentiating-bradykinin activity. Bradykinin-potentiating peptides are also found in Viperidea and Elapidea snake species such as Agkistrodon halys pallas, Bothrop jararacussu, Bothriechis lateralis, Bothriechis schlegelii, Macrovipera lebetina and Naja haje haje. Another example are the atrial natriuretic peptides which are hormones that are endogenously released when myocardium is stretched and overload in the body. These peptides cause natriuresis, inhibition of rennin-angiotensin systA tripeptide (Glutamic acid-Valine-Tryptophan) isolated from Bottrop atrox venom has been shown to protect against the dopaminergic neurons loss in Parkinson’s disease model. Similarly, neurotoxins from Mamba performed antagonist activity with acetylcholinesterase receptors that useful in therapeutic of Alzheimer’s disease. A secretory phospholipase A2 from Naja sputatrix reduced neuronal death and promote cell survival in the organotypic hippocampal culture and possess anti-apoptotic effects and recently, an low molecular weight fraction from B. jarararaca showed protection effects against apoptosis of hippocampal cells induced with H2O2. Interestingly, a molecule from South and Central America snake viper, Bothrops asper venom was found to reduce amyloid beta plaque that accumulated in Alzheimer’s disease patient neurons through enhancement Endothelian Converting Enzyme-1 and Neprilysin activity that lead to degradation of amyloid beta protein. These studies showed the potential snake venoms as neuroroprotection or neurotherapeutic source. On the other hand, research on marine organisms have moved from purely chemical exercise of isolating novel structures to a collaborative effort between marine chemists, molecular pharmacologists, and cell biologists. In the advent of the advanced `omics’ technologies in integrative biology, the future of the drug discovery should be enhanced and facilitated. Various bioassays attempting to elucidate the mechanisms between specific enzymes, receptors, and recombinant whole cells are commonly used for identifying marine natural products with potential biomedical uses. This presentation will provide a baseline for further studies on extracting molecules that are potentially importance for therapeutics applications. 2018-10 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/67157/1/67157_MARINE%20ANIMALS%20AND%20SNAKES-%20abstract.pdf Othman, Iekhsan and Zainal Abidin, Syafiq Asnawi and Abdullah, Nur Atiqah and Shaikh, Mohd Farooq and Ismail, Ahmad Khaldun and Ahmad Rusmili, Muhamad Rusdi and Naidu, Rakesh (2018) Marine animals and snakes: their venoms and poisons for therapeutics. In: ASEAN Marine Animals & Snake Envenoming (Poisoning) Management - AMSEM 2018, 23rd-26th October 2018, Yogjakarta, Indonesia. (Unpublished) http://mstamsem.blogspot.com/p/abstract.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RA Public aspects of medicine RA644.3 Public Health. Hygiene. Preventive Medicine - Chronic and Noninfectious Diseases and Public Health RM Therapeutics. Pharmacology RM300 Drugs and their action
spellingShingle	RA Public aspects of medicine RA644.3 Public Health. Hygiene. Preventive Medicine - Chronic and Noninfectious Diseases and Public Health RM Therapeutics. Pharmacology RM300 Drugs and their action Othman, Iekhsan Zainal Abidin, Syafiq Asnawi Abdullah, Nur Atiqah Shaikh, Mohd Farooq Ismail, Ahmad Khaldun Ahmad Rusmili, Muhamad Rusdi Naidu, Rakesh Marine animals and snakes: their venoms and poisons for therapeutics
description	The discovery and modification of angiotensin converting enzyme inhibitor. Angiotensin converting enzyme inhibitor creation starts when Bothrops jararaca venom was found to be causing hypotension by potentiating-bradykinin activity. Bradykinin-potentiating peptides are also found in Viperidea and Elapidea snake species such as Agkistrodon halys pallas, Bothrop jararacussu, Bothriechis lateralis, Bothriechis schlegelii, Macrovipera lebetina and Naja haje haje. Another example are the atrial natriuretic peptides which are hormones that are endogenously released when myocardium is stretched and overload in the body. These peptides cause natriuresis, inhibition of rennin-angiotensin systA tripeptide (Glutamic acid-Valine-Tryptophan) isolated from Bottrop atrox venom has been shown to protect against the dopaminergic neurons loss in Parkinson’s disease model. Similarly, neurotoxins from Mamba performed antagonist activity with acetylcholinesterase receptors that useful in therapeutic of Alzheimer’s disease. A secretory phospholipase A2 from Naja sputatrix reduced neuronal death and promote cell survival in the organotypic hippocampal culture and possess anti-apoptotic effects and recently, an low molecular weight fraction from B. jarararaca showed protection effects against apoptosis of hippocampal cells induced with H2O2. Interestingly, a molecule from South and Central America snake viper, Bothrops asper venom was found to reduce amyloid beta plaque that accumulated in Alzheimer’s disease patient neurons through enhancement Endothelian Converting Enzyme-1 and Neprilysin activity that lead to degradation of amyloid beta protein. These studies showed the potential snake venoms as neuroroprotection or neurotherapeutic source. On the other hand, research on marine organisms have moved from purely chemical exercise of isolating novel structures to a collaborative effort between marine chemists, molecular pharmacologists, and cell biologists. In the advent of the advanced `omics’ technologies in integrative biology, the future of the drug discovery should be enhanced and facilitated. Various bioassays attempting to elucidate the mechanisms between specific enzymes, receptors, and recombinant whole cells are commonly used for identifying marine natural products with potential biomedical uses. This presentation will provide a baseline for further studies on extracting molecules that are potentially importance for therapeutics applications.
format	Conference or Workshop Item
author	Othman, Iekhsan Zainal Abidin, Syafiq Asnawi Abdullah, Nur Atiqah Shaikh, Mohd Farooq Ismail, Ahmad Khaldun Ahmad Rusmili, Muhamad Rusdi Naidu, Rakesh
author_facet	Othman, Iekhsan Zainal Abidin, Syafiq Asnawi Abdullah, Nur Atiqah Shaikh, Mohd Farooq Ismail, Ahmad Khaldun Ahmad Rusmili, Muhamad Rusdi Naidu, Rakesh
author_sort	Othman, Iekhsan
title	Marine animals and snakes: their venoms and poisons for therapeutics
title_short	Marine animals and snakes: their venoms and poisons for therapeutics
title_full	Marine animals and snakes: their venoms and poisons for therapeutics
title_fullStr	Marine animals and snakes: their venoms and poisons for therapeutics
title_full_unstemmed	Marine animals and snakes: their venoms and poisons for therapeutics
title_sort	marine animals and snakes: their venoms and poisons for therapeutics
publishDate	2018
url	http://irep.iium.edu.my/67157/ http://irep.iium.edu.my/67157/ http://irep.iium.edu.my/67157/1/67157_MARINE%20ANIMALS%20AND%20SNAKES-%20abstract.pdf
first_indexed	2023-09-18T21:35:21Z
last_indexed	2023-09-18T21:35:21Z
_version_	1777412783682355200

Marine animals and snakes: their venoms and poisons for therapeutics

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