Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms

Differential scanning calorimetry (DSC) and attenuated total reflectance (ATR) infrared spectroscopy methods were used to investigate the compatibility between an active pharmaceutical ingredients (API), paracetamol (PCM), with excipients such as honey, xanthan gum, sodium methylparaben, sodium prop...

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Main Authors:	Haris, Muhammad Salahuddin, Mohamed, Farahidah, Doolaanea, Abd Almonem, Mohd Shafri, Mohd Affendi
Format:	Conference or Workshop Item
Language:	English English
Published:	2016
Subjects:	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/67144/ http://irep.iium.edu.my/67144/1/programmebook.pdf http://irep.iium.edu.my/67144/2/SLIDE%20ICIP%202016%20BR%20SOLAH.pdf

id	iium-67144
recordtype	eprints
spelling	iium-671442018-12-14T04:16:29Z http://irep.iium.edu.my/67144/ Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms Haris, Muhammad Salahuddin Mohamed, Farahidah Doolaanea, Abd Almonem Mohd Shafri, Mohd Affendi RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Differential scanning calorimetry (DSC) and attenuated total reflectance (ATR) infrared spectroscopy methods were used to investigate the compatibility between an active pharmaceutical ingredients (API), paracetamol (PCM), with excipients such as honey, xanthan gum, sodium methylparaben, sodium propylparaben and sodium citrate. To assess the possible interactions between PCM and other excipients, the melting point of individual PCM was compared to the melting point of binary mixtures PCM and excipients (physical mixing of PCM:excipient of 1:1 ratio). DSC curve showed a sharp endothermic peak at 170.8°C corresponding to the PCM melting point (literature value: 169◦C - 172◦C). The melting points of PCM remained similar for all PCM binary mixtures except for PCM-sodium methylparaben and PCM-sodium propylparaben binary mixtures where disappearance of PCM melting points were exhibited by the thermogram. ATR infrared spectroscopy was used to support and assist the interpretation of DSC findings. On the basis of ATR supportive infrared spectra, incompatibilities between PCM and other excipients were not detected. 2016-08-15 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/67144/1/programmebook.pdf application/pdf en http://irep.iium.edu.my/67144/2/SLIDE%20ICIP%202016%20BR%20SOLAH.pdf Haris, Muhammad Salahuddin and Mohamed, Farahidah and Doolaanea, Abd Almonem and Mohd Shafri, Mohd Affendi (2016) Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms. In: International Conference on Industrial Pharmacy (2nd ICIP 2016), 15th-16th Aug. 2016, Kuantan, Pahang. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Haris, Muhammad Salahuddin Mohamed, Farahidah Doolaanea, Abd Almonem Mohd Shafri, Mohd Affendi Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms
description	Differential scanning calorimetry (DSC) and attenuated total reflectance (ATR) infrared spectroscopy methods were used to investigate the compatibility between an active pharmaceutical ingredients (API), paracetamol (PCM), with excipients such as honey, xanthan gum, sodium methylparaben, sodium propylparaben and sodium citrate. To assess the possible interactions between PCM and other excipients, the melting point of individual PCM was compared to the melting point of binary mixtures PCM and excipients (physical mixing of PCM:excipient of 1:1 ratio). DSC curve showed a sharp endothermic peak at 170.8°C corresponding to the PCM melting point (literature value: 169◦C - 172◦C). The melting points of PCM remained similar for all PCM binary mixtures except for PCM-sodium methylparaben and PCM-sodium propylparaben binary mixtures where disappearance of PCM melting points were exhibited by the thermogram. ATR infrared spectroscopy was used to support and assist the interpretation of DSC findings. On the basis of ATR supportive infrared spectra, incompatibilities between PCM and other excipients were not detected.
format	Conference or Workshop Item
author	Haris, Muhammad Salahuddin Mohamed, Farahidah Doolaanea, Abd Almonem Mohd Shafri, Mohd Affendi
author_facet	Haris, Muhammad Salahuddin Mohamed, Farahidah Doolaanea, Abd Almonem Mohd Shafri, Mohd Affendi
author_sort	Haris, Muhammad Salahuddin
title	Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms
title_short	Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms
title_full	Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms
title_fullStr	Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms
title_full_unstemmed	Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms
title_sort	compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms
publishDate	2016
url	http://irep.iium.edu.my/67144/ http://irep.iium.edu.my/67144/1/programmebook.pdf http://irep.iium.edu.my/67144/2/SLIDE%20ICIP%202016%20BR%20SOLAH.pdf
first_indexed	2023-09-18T21:35:20Z
last_indexed	2023-09-18T21:35:20Z
_version_	1777412782524727296

Compatibility study between paracetamol and pharmaceutical excipients used in liquid dosage forms

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