Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension

Commercial paracetamol (PCM) suspension is formulated with high amount of sugar and more than 7 excipients to mask the bitter taste of PCM and to achieve stable pharmaceutical suspension for an acceptable shelf-life. This over-the counter pharmaceutical is rampantly used to alleviate minor ailments...

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Main Authors:	Md Adib, Noor Adibah, Haris, Muhammad Salahuddin, Mohamed, Farahidah
Format:	Conference or Workshop Item
Language:	English English English
Published:	2013
Subjects:	RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/67129/ http://irep.iium.edu.my/67129/1/Tentative%20ICMUH%202013.pdf http://irep.iium.edu.my/67129/2/AbstractBook.pdf http://irep.iium.edu.my/67129/3/ICMUH2013.pdf

id	iium-67129
recordtype	eprints
spelling	iium-671292018-12-13T05:20:02Z http://irep.iium.edu.my/67129/ Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension Md Adib, Noor Adibah Haris, Muhammad Salahuddin Mohamed, Farahidah RS192 Materia Medica-Pharmaceutical Technology Commercial paracetamol (PCM) suspension is formulated with high amount of sugar and more than 7 excipients to mask the bitter taste of PCM and to achieve stable pharmaceutical suspension for an acceptable shelf-life. This over-the counter pharmaceutical is rampantly used to alleviate minor ailments and fever especially in infants and children but concern over its high sugar sweeteners content during repeated and prolonged treatment is worrying (e.g. dental caries). As such, this study aims to explore alternative PCM formulation by fusioning the PCM into honey alone without other excipients. Two types of honey have been tested, namely ‘Khaula’ and ‘Tualang’ which differ in viscosity and colour. Different processing variables had been tested as well including type of mixers, temperature and flow rate. The formulation were characterised for their particle size, stability and compatibility and the results were compared with commercial PCM suspension. PCM suspension prepared using highly viscous honey (Khaula) was found to be stable compared to the commercial PCM in contrast to PCM-Tualang suspension. Compatibility study based on Fourier-Transform Infra-Red (FTIR) showed similar spectra for all PCM-honey as compared to commercial PCM. Particle size of PCM-Khaula was larger than PCM-Tualang due to different processing method and equipments employed. To conclude, honey appeared to be compatible with PCM and produced stable suspension without the need for other excipients. The fusion of honey is also expected to confer its wholesome benefits to the pharmaceuticals and may improve the treatment of relevant indication. 2013-11-21 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/67129/1/Tentative%20ICMUH%202013.pdf application/pdf en http://irep.iium.edu.my/67129/2/AbstractBook.pdf application/pdf en http://irep.iium.edu.my/67129/3/ICMUH2013.pdf Md Adib, Noor Adibah and Haris, Muhammad Salahuddin and Mohamed, Farahidah (2013) Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension. In: 3rd International Conference on Medicinal Use of Honeybee Products, 20th-22nd November 2013, Makassar, Indonesia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology Md Adib, Noor Adibah Haris, Muhammad Salahuddin Mohamed, Farahidah Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension
description	Commercial paracetamol (PCM) suspension is formulated with high amount of sugar and more than 7 excipients to mask the bitter taste of PCM and to achieve stable pharmaceutical suspension for an acceptable shelf-life. This over-the counter pharmaceutical is rampantly used to alleviate minor ailments and fever especially in infants and children but concern over its high sugar sweeteners content during repeated and prolonged treatment is worrying (e.g. dental caries). As such, this study aims to explore alternative PCM formulation by fusioning the PCM into honey alone without other excipients. Two types of honey have been tested, namely ‘Khaula’ and ‘Tualang’ which differ in viscosity and colour. Different processing variables had been tested as well including type of mixers, temperature and flow rate. The formulation were characterised for their particle size, stability and compatibility and the results were compared with commercial PCM suspension. PCM suspension prepared using highly viscous honey (Khaula) was found to be stable compared to the commercial PCM in contrast to PCM-Tualang suspension. Compatibility study based on Fourier-Transform Infra-Red (FTIR) showed similar spectra for all PCM-honey as compared to commercial PCM. Particle size of PCM-Khaula was larger than PCM-Tualang due to different processing method and equipments employed. To conclude, honey appeared to be compatible with PCM and produced stable suspension without the need for other excipients. The fusion of honey is also expected to confer its wholesome benefits to the pharmaceuticals and may improve the treatment of relevant indication.
format	Conference or Workshop Item
author	Md Adib, Noor Adibah Haris, Muhammad Salahuddin Mohamed, Farahidah
author_facet	Md Adib, Noor Adibah Haris, Muhammad Salahuddin Mohamed, Farahidah
author_sort	Md Adib, Noor Adibah
title	Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension
title_short	Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension
title_full	Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension
title_fullStr	Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension
title_full_unstemmed	Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension
title_sort	fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension
publishDate	2013
url	http://irep.iium.edu.my/67129/ http://irep.iium.edu.my/67129/1/Tentative%20ICMUH%202013.pdf http://irep.iium.edu.my/67129/2/AbstractBook.pdf http://irep.iium.edu.my/67129/3/ICMUH2013.pdf
first_indexed	2023-09-18T21:35:19Z
last_indexed	2023-09-18T21:35:19Z
_version_	1777412781182550016

Fusion between contemporary medicine (paracetamol) and prophetic medicine (honey) as pharmaceutical suspension

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