The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation

The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation

The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and its combination with fib...

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Main Authors: Balakrishnan, Theenesh, Zulkifly, Ahmad Hafiz, Mohd Jan, Nurul Hafiza, Ibrahim, Mohd Zulfadzli, Shaban, Munirah, Md Nazir, Noorhidayah
Format: Article
Language:English
Published: Tissue Engineering and Regenerative Medicine Society of Malaysia 2017
Subjects:
RD701 Orthopedics
Online Access:http://irep.iium.edu.my/67000/
http://irep.iium.edu.my/67000/
http://irep.iium.edu.my/67000/1/RR-270118-003.pdf
id iium-67000
recordtype eprints
spelling iium-670002018-10-25T01:44:10Z http://irep.iium.edu.my/67000/ The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation Balakrishnan, Theenesh Zulkifly, Ahmad Hafiz Mohd Jan, Nurul Hafiza Ibrahim, Mohd Zulfadzli Shaban, Munirah Md Nazir, Noorhidayah RD701 Orthopedics The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and its combination with fibrin. The objective of this study is to compare biocompatibility and biodegradability of polymer (PLGA combined with fibrin) with PLGA for intra-articular screw fixation through micro-CT scan evaluation. We used fabricated PLGA(65:35) scaffolds in combination with autologous fibrin for an in vivo prospective research. A total of 9 New Zealand White Rabbits (NZWR) were operated and the scaffolds were implanted at both medial and lateral femoral condyles of the right knee and those with fibrin at the left knee. Post implantation, evaluation was done at 6, 12 and 24 weeks (3 NZWR in each group). For microradiological assessment, micro CT (Skyscan 1176) was used. The combination of PLGA and fibrin have better biocompatibility, showed faster biodegradation and more quantitative integration of osseous tissues. Biodegradable polymer PLGA with incorporation of fibrin results in superior outcome compared to usage of other current biodegradable polymers. Tissue Engineering and Regenerative Medicine Society of Malaysia 2017-12-29 Article PeerReviewed application/pdf en http://irep.iium.edu.my/67000/1/RR-270118-003.pdf Balakrishnan, Theenesh and Zulkifly, Ahmad Hafiz and Mohd Jan, Nurul Hafiza and Ibrahim, Mohd Zulfadzli and Shaban, Munirah and Md Nazir, Noorhidayah (2017) The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation. Regenerative Research, 6 (1). p. 1. E-ISSN 2232-0822 http://regres.tesma.org.my/pdf/RR-270118-003.pdf
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RD701 Orthopedics
spellingShingle RD701 Orthopedics
Balakrishnan, Theenesh
Zulkifly, Ahmad Hafiz
Mohd Jan, Nurul Hafiza
Ibrahim, Mohd Zulfadzli
Shaban, Munirah
Md Nazir, Noorhidayah
The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation
description The great potential of biodegradable polymers in orthopaedic surgery is gradually being recognized. PLGA is one of the common polymers used. However, long term outcomes, with regards to PLGA, are still not well documented. Hence, we attempted to study the outcome of PLGA and its combination with fibrin. The objective of this study is to compare biocompatibility and biodegradability of polymer (PLGA combined with fibrin) with PLGA for intra-articular screw fixation through micro-CT scan evaluation. We used fabricated PLGA(65:35) scaffolds in combination with autologous fibrin for an in vivo prospective research. A total of 9 New Zealand White Rabbits (NZWR) were operated and the scaffolds were implanted at both medial and lateral femoral condyles of the right knee and those with fibrin at the left knee. Post implantation, evaluation was done at 6, 12 and 24 weeks (3 NZWR in each group). For microradiological assessment, micro CT (Skyscan 1176) was used. The combination of PLGA and fibrin have better biocompatibility, showed faster biodegradation and more quantitative integration of osseous tissues. Biodegradable polymer PLGA with incorporation of fibrin results in superior outcome compared to usage of other current biodegradable polymers.
format Article
author Balakrishnan, Theenesh
Zulkifly, Ahmad Hafiz
Mohd Jan, Nurul Hafiza
Ibrahim, Mohd Zulfadzli
Shaban, Munirah
Md Nazir, Noorhidayah
author_facet Balakrishnan, Theenesh
Zulkifly, Ahmad Hafiz
Mohd Jan, Nurul Hafiza
Ibrahim, Mohd Zulfadzli
Shaban, Munirah
Md Nazir, Noorhidayah
author_sort Balakrishnan, Theenesh
title The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation
title_short The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation
title_full The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation
title_fullStr The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation
title_full_unstemmed The in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in New Zealand white rabbit model-the micro-ct scan evaluation
title_sort in vivo study comparing biocompatibility and biodegradability of poly lactic-co-glycolic acid (plga) combined with autologous fibrin versus plga for intra articular screw fixation in new zealand white rabbit model-the micro-ct scan evaluation
publisher Tissue Engineering and Regenerative Medicine Society of Malaysia
publishDate 2017
url http://irep.iium.edu.my/67000/
http://irep.iium.edu.my/67000/
http://irep.iium.edu.my/67000/1/RR-270118-003.pdf
first_indexed 2023-09-18T21:35:08Z
last_indexed 2023-09-18T21:35:08Z
_version_ 1777412769783480320

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