A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines

Natural polyamines such as putrescine, spermidine, and spermine are crucial for cell growth and proliferation. However, over accumulation of polyamines can lead to the worst scenario which is the progression of cancer cells. The upregulation of polyamine transport system (PTS) activity leads to an o...

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Main Authors:	Abdul Ghani, Radiah, Halim, Suhana, Jamil, Masnizahani, Sahabudin, Adzly Hairee
Format:	Book Chapter
Language:	English
Published:	UPM Press 2018
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/66989/ http://irep.iium.edu.my/66989/ http://irep.iium.edu.my/66989/1/66989_A%20Review%20on%20Polyamine%20Analogues-ebook.pdf

id	iium-66989
recordtype	eprints
spelling	iium-669892018-10-26T07:41:21Z http://irep.iium.edu.my/66989/ A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines Abdul Ghani, Radiah Halim, Suhana Jamil, Masnizahani Sahabudin, Adzly Hairee QP Physiology Natural polyamines such as putrescine, spermidine, and spermine are crucial for cell growth and proliferation. However, over accumulation of polyamines can lead to the worst scenario which is the progression of cancer cells. The upregulation of polyamine transport system (PTS) activity leads to an opportunity to develop more specific and effective cancer treatment. Based on this strategy, polyamines are utilized as a vector which inserted with known cytotoxic compound. Perhaps, anticancer drugs that attached to the polyamines are directly targeted the cancer cells without affecting other normal cells and the side effects of the drugs could be reduced or minimized. Therefore the aim of this paper is to review the polyamine analogues which have been synthesized and evaluated as potential anti-cancer agent in various types of cancer cell lines. It is hope that the concept of selective targeting of cancer cells via the polyamine transport system will lead to the development of novel and effective anti-cancer therapies. UPM Press 2018-08 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/66989/1/66989_A%20Review%20on%20Polyamine%20Analogues-ebook.pdf Abdul Ghani, Radiah and Halim, Suhana and Jamil, Masnizahani and Sahabudin, Adzly Hairee (2018) A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines. In: Biology: emerging theme in fundamental and applied science. UPM Press, Serdang, Selangor, pp. 154-161. http://www.science.upm.edu.my/ebook-3213
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology
spellingShingle	QP Physiology Abdul Ghani, Radiah Halim, Suhana Jamil, Masnizahani Sahabudin, Adzly Hairee A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines
description	Natural polyamines such as putrescine, spermidine, and spermine are crucial for cell growth and proliferation. However, over accumulation of polyamines can lead to the worst scenario which is the progression of cancer cells. The upregulation of polyamine transport system (PTS) activity leads to an opportunity to develop more specific and effective cancer treatment. Based on this strategy, polyamines are utilized as a vector which inserted with known cytotoxic compound. Perhaps, anticancer drugs that attached to the polyamines are directly targeted the cancer cells without affecting other normal cells and the side effects of the drugs could be reduced or minimized. Therefore the aim of this paper is to review the polyamine analogues which have been synthesized and evaluated as potential anti-cancer agent in various types of cancer cell lines. It is hope that the concept of selective targeting of cancer cells via the polyamine transport system will lead to the development of novel and effective anti-cancer therapies.
format	Book Chapter
author	Abdul Ghani, Radiah Halim, Suhana Jamil, Masnizahani Sahabudin, Adzly Hairee
author_facet	Abdul Ghani, Radiah Halim, Suhana Jamil, Masnizahani Sahabudin, Adzly Hairee
author_sort	Abdul Ghani, Radiah
title	A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines
title_short	A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines
title_full	A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines
title_fullStr	A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines
title_full_unstemmed	A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines
title_sort	review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines
publisher	UPM Press
publishDate	2018
url	http://irep.iium.edu.my/66989/ http://irep.iium.edu.my/66989/ http://irep.iium.edu.my/66989/1/66989_A%20Review%20on%20Polyamine%20Analogues-ebook.pdf
first_indexed	2023-09-18T21:35:07Z
last_indexed	2023-09-18T21:35:07Z
_version_	1777412768742244352

A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines

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