Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines

Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines

Naringin has been reported to possess diverse pharmacological properties, including anti-arthritic and anti-inflammatory activities. The aim of the present study was to determine the potential anti-inflammatory effect of naringin in a mouse model of carrageenan-induced pleurisy. A single dose of nar...

Full description

Bibliographic Details
Main Authors: Ahmad, Sheikh Fayaz, Attia, Sabry M., Bakheet, Saleh A., Zoheir, Khairy M. A., Ansari, Mushtaq Ahmad, Korashy, Hesham M., Abdel-Hamied, Hala E., Ashour, Abdelkader Elbadawy Abbas, Abd-Allah, Adel R. A.
Format: Article
Language:English
English
Published: Springer Nature Switzerland AG. 2015
Subjects:
RM300 Drugs and their action
Online Access:http://irep.iium.edu.my/66957/
http://irep.iium.edu.my/66957/
http://irep.iium.edu.my/66957/
http://irep.iium.edu.my/66957/1/Naringin%20Attenuates%20the%20Development%20of%20Carrageenan-Induced%20Acute%20Lung%20Inflammation%20Through%20Inhibition%20of%20NF-%CE%BAb%2C%20STAT3%20and%20Pro-Inflammatory%20Mediators%20and%20Enhancement%20of%20I%CE%BAB%CE%B1%20and%20Anti-Inflammatory%20Cytokines.pdf
http://irep.iium.edu.my/66957/7/66957_Scopus%20-%20Document%20details.pdf
id iium-66957
recordtype eprints
spelling iium-669572019-01-06T07:57:08Z http://irep.iium.edu.my/66957/ Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines Ahmad, Sheikh Fayaz Attia, Sabry M. Bakheet, Saleh A. Zoheir, Khairy M. A. Ansari, Mushtaq Ahmad Korashy, Hesham M. Abdel-Hamied, Hala E. Ashour, Abdelkader Elbadawy Abbas Abd-Allah, Adel R. A. RM300 Drugs and their action Naringin has been reported to possess diverse pharmacological properties, including anti-arthritic and anti-inflammatory activities. The aim of the present study was to determine the potential anti-inflammatory effect of naringin in a mouse model of carrageenan-induced pleurisy. A single dose of naringin (40 and 80 mg/kg) was administered per oral (p.o.) 1 h before carrageenan (Cg) administration. Pro- and anti-inflammatory cytokines were analysed in pleural fluid. We also assessed the effects of naringin on the expression levels of iNOS, inducible cyclooxygenase isoform (COX-2), ICAM-1, MIP-2, PGE2, STAT3, TGF-β1, nuclear factor kappa B (NF-κB) and inhibitor of kappa B (IκBα) in lung tissue. The histological examinations revealed anti-inflammatory effect of naringin while Cg group deteriorated. Naringin downregulated Th1 and upregulated Th2 cytokines. Western blot analyses revealed increased protein expression of NF-κB, STAT3 and COX-2 and decreased IκBα in response to Cg treatment, which were reversed by the treatment with naringin. In the Cg group, mRNA expression levels of pro-inflammatory mediators upregulated and anti-inflammatory mediators downregulated. Naringin reversed these actions. Springer Nature Switzerland AG. 2015-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66957/1/Naringin%20Attenuates%20the%20Development%20of%20Carrageenan-Induced%20Acute%20Lung%20Inflammation%20Through%20Inhibition%20of%20NF-%CE%BAb%2C%20STAT3%20and%20Pro-Inflammatory%20Mediators%20and%20Enhancement%20of%20I%CE%BAB%CE%B1%20and%20Anti-Inflammatory%20Cytokines.pdf application/pdf en http://irep.iium.edu.my/66957/7/66957_Scopus%20-%20Document%20details.pdf Ahmad, Sheikh Fayaz and Attia, Sabry M. and Bakheet, Saleh A. and Zoheir, Khairy M. A. and Ansari, Mushtaq Ahmad and Korashy, Hesham M. and Abdel-Hamied, Hala E. and Ashour, Abdelkader Elbadawy Abbas and Abd-Allah, Adel R. A. (2015) Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines. Inflammation, 38 (2). pp. 846-857. ISSN 0360-3997 E-ISSN 1573-2576 https://link.springer.com/journal/10753 DOI: 10.1007/s10753-014-9994-y
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic RM300 Drugs and their action
spellingShingle RM300 Drugs and their action
Ahmad, Sheikh Fayaz
Attia, Sabry M.
Bakheet, Saleh A.
Zoheir, Khairy M. A.
Ansari, Mushtaq Ahmad
Korashy, Hesham M.
Abdel-Hamied, Hala E.
Ashour, Abdelkader Elbadawy Abbas
Abd-Allah, Adel R. A.
Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines
description Naringin has been reported to possess diverse pharmacological properties, including anti-arthritic and anti-inflammatory activities. The aim of the present study was to determine the potential anti-inflammatory effect of naringin in a mouse model of carrageenan-induced pleurisy. A single dose of naringin (40 and 80 mg/kg) was administered per oral (p.o.) 1 h before carrageenan (Cg) administration. Pro- and anti-inflammatory cytokines were analysed in pleural fluid. We also assessed the effects of naringin on the expression levels of iNOS, inducible cyclooxygenase isoform (COX-2), ICAM-1, MIP-2, PGE2, STAT3, TGF-β1, nuclear factor kappa B (NF-κB) and inhibitor of kappa B (IκBα) in lung tissue. The histological examinations revealed anti-inflammatory effect of naringin while Cg group deteriorated. Naringin downregulated Th1 and upregulated Th2 cytokines. Western blot analyses revealed increased protein expression of NF-κB, STAT3 and COX-2 and decreased IκBα in response to Cg treatment, which were reversed by the treatment with naringin. In the Cg group, mRNA expression levels of pro-inflammatory mediators upregulated and anti-inflammatory mediators downregulated. Naringin reversed these actions.
format Article
author Ahmad, Sheikh Fayaz
Attia, Sabry M.
Bakheet, Saleh A.
Zoheir, Khairy M. A.
Ansari, Mushtaq Ahmad
Korashy, Hesham M.
Abdel-Hamied, Hala E.
Ashour, Abdelkader Elbadawy Abbas
Abd-Allah, Adel R. A.
author_facet Ahmad, Sheikh Fayaz
Attia, Sabry M.
Bakheet, Saleh A.
Zoheir, Khairy M. A.
Ansari, Mushtaq Ahmad
Korashy, Hesham M.
Abdel-Hamied, Hala E.
Ashour, Abdelkader Elbadawy Abbas
Abd-Allah, Adel R. A.
author_sort Ahmad, Sheikh Fayaz
title Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines
title_short Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines
title_full Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines
title_fullStr Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines
title_full_unstemmed Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines
title_sort naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of nf-κb, stat3 and pro-inflammatory mediators and enhancement of iκbα and anti-inflammatory cytokines
publisher Springer Nature Switzerland AG.
publishDate 2015
url http://irep.iium.edu.my/66957/
http://irep.iium.edu.my/66957/
http://irep.iium.edu.my/66957/
http://irep.iium.edu.my/66957/1/Naringin%20Attenuates%20the%20Development%20of%20Carrageenan-Induced%20Acute%20Lung%20Inflammation%20Through%20Inhibition%20of%20NF-%CE%BAb%2C%20STAT3%20and%20Pro-Inflammatory%20Mediators%20and%20Enhancement%20of%20I%CE%BAB%CE%B1%20and%20Anti-Inflammatory%20Cytokines.pdf
http://irep.iium.edu.my/66957/7/66957_Scopus%20-%20Document%20details.pdf
first_indexed 2023-09-18T21:35:04Z
last_indexed 2023-09-18T21:35:04Z
_version_ 1777412765839785984

Similar Items