Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity

A hydroacetone extract was prepared from seeds of Phoenix dactylifera L. var. Khalas, which is an industrial by-product of date processing. The proanthocyanidin nature of the extract (coded as DTX) was characterized by phytochemical and nuclear magnetic resonance (NMR) analyses. The total phenol/pro...

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Main Authors:	Ahmed, Atallah F., Al-Qahtani, Jawaher H., Al-Yousef, Hanan M., Al-Said, Mansour S., Ashour, Abdelkader Elbadawy Abbas, Al-Sohaibani, Mohammed, Rafatullah, Syed
Format:	Article
Language:	English English
Published:	Mary Ann Liebert, Inc 2015
Subjects:	RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/66891/ http://irep.iium.edu.my/66891/ http://irep.iium.edu.my/66891/ http://irep.iium.edu.my/66891/1/Proanthocyanidin-Rich%20Date%20Seed%20Extract%20Protects%20Against%20Chemically%20Induced%20Hepatorenal%20Toxicity.pdf http://irep.iium.edu.my/66891/7/66891_Scopus%20-%20Document%20details.pdf

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spelling	iium-668912019-01-04T08:38:11Z http://irep.iium.edu.my/66891/ Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity Ahmed, Atallah F. Al-Qahtani, Jawaher H. Al-Yousef, Hanan M. Al-Said, Mansour S. Ashour, Abdelkader Elbadawy Abbas Al-Sohaibani, Mohammed Rafatullah, Syed RM300 Drugs and their action A hydroacetone extract was prepared from seeds of Phoenix dactylifera L. var. Khalas, which is an industrial by-product of date processing. The proanthocyanidin nature of the extract (coded as DTX) was characterized by phytochemical and nuclear magnetic resonance (NMR) analyses. The total phenol/proanthocyanidin content and antioxidant activity of DTX were estimated by Folin-Ciocalteu, vanillin-sulfuric acid, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays, respectively. The hepatorenal protective activity of DTX was evaluated using CCl4-induced toxicity model in rats, in comparison with silymarin (SYL). Results of the histopathological examination and measurements of various hepatorenal serum indices and tissue biochemical markers demonstrated that DTX displayed marked protective potential against CCl4-induced liver and kidney injury at 100 mg/kg/rat. Relative to the control CCl4-intoxicated group, pretreatment with DTX significantly (P<.001) suppressed the elevated serum levels of alanine aminotransferase and aspartate aminotransferase (ALT and AST), alkaline phosphatase (ALP), γ-glutamyl transferase (GGT), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), bilirubin, creatinine, and calcium, whereas it significantly (P<.001) increased the diminished serum levels of high-density lipoprotein cholesterol (HDL-C) and total protein (TP). Moreover, DTX significantly decreased malondialdehyde (MDA) formation and increased TP synthesis in hepatorenal tissues compared with the intoxicated control. The improvement in biochemical parameters by DTX was observed in a dose-dependent manner and confirmed by restoration of normal histological features. The acute toxicity test of DTX in rats revealed safety of the extract. This study reveals that DTX enhances the recovery from xenobiotics-induced toxicity initiated by free radicals. Mary Ann Liebert, Inc 2015-03-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66891/1/Proanthocyanidin-Rich%20Date%20Seed%20Extract%20Protects%20Against%20Chemically%20Induced%20Hepatorenal%20Toxicity.pdf application/pdf en http://irep.iium.edu.my/66891/7/66891_Scopus%20-%20Document%20details.pdf Ahmed, Atallah F. and Al-Qahtani, Jawaher H. and Al-Yousef, Hanan M. and Al-Said, Mansour S. and Ashour, Abdelkader Elbadawy Abbas and Al-Sohaibani, Mohammed and Rafatullah, Syed (2015) Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity. Journal of Medicinal Food, 18 (3). pp. 280-289. ISSN 1096-620X E-ISSN 1557-7600 https://home.liebertpub.com/publications/journal-of-medicinal-food/38/overview DOI: 10.1089/jmf.2014.3157
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM300 Drugs and their action
spellingShingle	RM300 Drugs and their action Ahmed, Atallah F. Al-Qahtani, Jawaher H. Al-Yousef, Hanan M. Al-Said, Mansour S. Ashour, Abdelkader Elbadawy Abbas Al-Sohaibani, Mohammed Rafatullah, Syed Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity
description	A hydroacetone extract was prepared from seeds of Phoenix dactylifera L. var. Khalas, which is an industrial by-product of date processing. The proanthocyanidin nature of the extract (coded as DTX) was characterized by phytochemical and nuclear magnetic resonance (NMR) analyses. The total phenol/proanthocyanidin content and antioxidant activity of DTX were estimated by Folin-Ciocalteu, vanillin-sulfuric acid, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays, respectively. The hepatorenal protective activity of DTX was evaluated using CCl4-induced toxicity model in rats, in comparison with silymarin (SYL). Results of the histopathological examination and measurements of various hepatorenal serum indices and tissue biochemical markers demonstrated that DTX displayed marked protective potential against CCl4-induced liver and kidney injury at 100 mg/kg/rat. Relative to the control CCl4-intoxicated group, pretreatment with DTX significantly (P<.001) suppressed the elevated serum levels of alanine aminotransferase and aspartate aminotransferase (ALT and AST), alkaline phosphatase (ALP), γ-glutamyl transferase (GGT), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), bilirubin, creatinine, and calcium, whereas it significantly (P<.001) increased the diminished serum levels of high-density lipoprotein cholesterol (HDL-C) and total protein (TP). Moreover, DTX significantly decreased malondialdehyde (MDA) formation and increased TP synthesis in hepatorenal tissues compared with the intoxicated control. The improvement in biochemical parameters by DTX was observed in a dose-dependent manner and confirmed by restoration of normal histological features. The acute toxicity test of DTX in rats revealed safety of the extract. This study reveals that DTX enhances the recovery from xenobiotics-induced toxicity initiated by free radicals.
format	Article
author	Ahmed, Atallah F. Al-Qahtani, Jawaher H. Al-Yousef, Hanan M. Al-Said, Mansour S. Ashour, Abdelkader Elbadawy Abbas Al-Sohaibani, Mohammed Rafatullah, Syed
author_facet	Ahmed, Atallah F. Al-Qahtani, Jawaher H. Al-Yousef, Hanan M. Al-Said, Mansour S. Ashour, Abdelkader Elbadawy Abbas Al-Sohaibani, Mohammed Rafatullah, Syed
author_sort	Ahmed, Atallah F.
title	Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity
title_short	Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity
title_full	Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity
title_fullStr	Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity
title_full_unstemmed	Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity
title_sort	proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity
publisher	Mary Ann Liebert, Inc
publishDate	2015
url	http://irep.iium.edu.my/66891/ http://irep.iium.edu.my/66891/ http://irep.iium.edu.my/66891/ http://irep.iium.edu.my/66891/1/Proanthocyanidin-Rich%20Date%20Seed%20Extract%20Protects%20Against%20Chemically%20Induced%20Hepatorenal%20Toxicity.pdf http://irep.iium.edu.my/66891/7/66891_Scopus%20-%20Document%20details.pdf
first_indexed	2023-09-18T21:34:58Z
last_indexed	2023-09-18T21:34:58Z
_version_	1777412759665770496

Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity

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