Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation.
Histamine 4 receptor (H4R) is a novel target for the pharmacological modulation of histamine-mediated immune signals during inflammatory diseases. The purpose of this study was to assess the effects of the H4R agonist 4-methylhistamine dihydrochloride (4-MeH) and antagonist JNJ7777120 (JNJ) in the i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/66890/ http://irep.iium.edu.my/66890/ http://irep.iium.edu.my/66890/ http://irep.iium.edu.my/66890/1/Regulation%20of%20TNF-%CE%B1%20and%20NF-%CE%BAB%20activation%20through%20the%20JAK%20STAT%20signaling%20pathway%20downstream%20of%20histamine%204%20receptor%20in%20a%20rat%20model%20of%20LPS-induced%20joint%20inflammation..pdf http://irep.iium.edu.my/66890/7/66890_Scopus.pdf |