The effects of MDMA on brain: An in vivo study in rats

Background and objective : 3, 4-Methylenedioxymethamphetamine (MDMA) is a powerful central nervous system stimulant that acts by increasing the activity of several neurotransmitter systems. This study aimed to investigate the effect of different doses of MDMA on the level of serotonin in the brain m...

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Main Authors:	Zakaria, Fatin Haniza, Abu Bakar, Nor Hidayah, Mohamad, Nasir, Abdul Latif, Ahmad Zubaidi, Mor Japar Khan, Ed Simor Khan, Wan Ahmad, Wan Amir Nizam
Format:	Article
Language:	English
Published:	International Journal of Pharmaceutical Research and Allied Sciences (IJPRAS) 2018
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/66859/ http://irep.iium.edu.my/66859/ http://irep.iium.edu.my/66859/1/The%20effects%20og%20MDMA%20of%20brain%20an%20in%20vivo%20study%20in%20rats.pdf

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spelling	iium-668592018-10-22T06:41:09Z http://irep.iium.edu.my/66859/ The effects of MDMA on brain: An in vivo study in rats Zakaria, Fatin Haniza Abu Bakar, Nor Hidayah Mohamad, Nasir Abdul Latif, Ahmad Zubaidi Mor Japar Khan, Ed Simor Khan Wan Ahmad, Wan Amir Nizam RD701 Orthopedics Background and objective : 3, 4-Methylenedioxymethamphetamine (MDMA) is a powerful central nervous system stimulant that acts by increasing the activity of several neurotransmitter systems. This study aimed to investigate the effect of different doses of MDMA on the level of serotonin in the brain measured from the cerebrospinal fluid (CSF) and their effects on the neurons. Materials and methods : Twenty-six adult male rats were divided into 4 groups. The control group (n=7) received intraperitoneal (IP) injections of 1 mL/gm normal saline twice daily for one week. The MDMA treated groups (n= 6/7) were further subdivided into 3 groups, each receiving 5, 10 or 15mg/kg MDMA intraperitoneal (IP) injections twice daily for one week ; respectively. 24 hours after the last injection of the rats, the CSF was collected. The brains were dissected and processed for paraffin sections and stained by cresyl etch violet stain. Histology, morphometry and statistical analysis were done. Results : The administration of different doses of MDMA significantly increased the level of serotonin in comparison with the control group. The morphometry study indicated that the number of intact neurons in the hippocampus significantly decreased following the administration of different doses of MDMA comparing to the control group. The results also indicated that there was a strong negative correlation between the serotonin levels and the number of intact neurons. Conclusion : MDMA administration even at a low dose had degenerative effects on the neurons in the hippocampus as evidenced by morphometric study, and the intake should be avoided. International Journal of Pharmaceutical Research and Allied Sciences (IJPRAS) 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66859/1/The%20effects%20og%20MDMA%20of%20brain%20an%20in%20vivo%20study%20in%20rats.pdf Zakaria, Fatin Haniza and Abu Bakar, Nor Hidayah and Mohamad, Nasir and Abdul Latif, Ahmad Zubaidi and Mor Japar Khan, Ed Simor Khan and Wan Ahmad, Wan Amir Nizam (2018) The effects of MDMA on brain: An in vivo study in rats. International Journal of Pharmaceutical Research &Allied Sciences, 7 (3). pp. 126-137. ISSN 2277-3657 http://ijpras.com/vol7-iss3/IJPRAS-2018-7-3-126-137.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Zakaria, Fatin Haniza Abu Bakar, Nor Hidayah Mohamad, Nasir Abdul Latif, Ahmad Zubaidi Mor Japar Khan, Ed Simor Khan Wan Ahmad, Wan Amir Nizam The effects of MDMA on brain: An in vivo study in rats
description	Background and objective : 3, 4-Methylenedioxymethamphetamine (MDMA) is a powerful central nervous system stimulant that acts by increasing the activity of several neurotransmitter systems. This study aimed to investigate the effect of different doses of MDMA on the level of serotonin in the brain measured from the cerebrospinal fluid (CSF) and their effects on the neurons. Materials and methods : Twenty-six adult male rats were divided into 4 groups. The control group (n=7) received intraperitoneal (IP) injections of 1 mL/gm normal saline twice daily for one week. The MDMA treated groups (n= 6/7) were further subdivided into 3 groups, each receiving 5, 10 or 15mg/kg MDMA intraperitoneal (IP) injections twice daily for one week ; respectively. 24 hours after the last injection of the rats, the CSF was collected. The brains were dissected and processed for paraffin sections and stained by cresyl etch violet stain. Histology, morphometry and statistical analysis were done. Results : The administration of different doses of MDMA significantly increased the level of serotonin in comparison with the control group. The morphometry study indicated that the number of intact neurons in the hippocampus significantly decreased following the administration of different doses of MDMA comparing to the control group. The results also indicated that there was a strong negative correlation between the serotonin levels and the number of intact neurons. Conclusion : MDMA administration even at a low dose had degenerative effects on the neurons in the hippocampus as evidenced by morphometric study, and the intake should be avoided.
format	Article
author	Zakaria, Fatin Haniza Abu Bakar, Nor Hidayah Mohamad, Nasir Abdul Latif, Ahmad Zubaidi Mor Japar Khan, Ed Simor Khan Wan Ahmad, Wan Amir Nizam
author_facet	Zakaria, Fatin Haniza Abu Bakar, Nor Hidayah Mohamad, Nasir Abdul Latif, Ahmad Zubaidi Mor Japar Khan, Ed Simor Khan Wan Ahmad, Wan Amir Nizam
author_sort	Zakaria, Fatin Haniza
title	The effects of MDMA on brain: An in vivo study in rats
title_short	The effects of MDMA on brain: An in vivo study in rats
title_full	The effects of MDMA on brain: An in vivo study in rats
title_fullStr	The effects of MDMA on brain: An in vivo study in rats
title_full_unstemmed	The effects of MDMA on brain: An in vivo study in rats
title_sort	effects of mdma on brain: an in vivo study in rats
publisher	International Journal of Pharmaceutical Research and Allied Sciences (IJPRAS)
publishDate	2018
url	http://irep.iium.edu.my/66859/ http://irep.iium.edu.my/66859/ http://irep.iium.edu.my/66859/1/The%20effects%20og%20MDMA%20of%20brain%20an%20in%20vivo%20study%20in%20rats.pdf
first_indexed	2023-09-18T21:34:56Z
last_indexed	2023-09-18T21:34:56Z
_version_	1777412757724856320

The effects of MDMA on brain: An in vivo study in rats

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