Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion

Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. Thi...

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Main Authors:	Helal Uddin, Abul Bashar Mohammed, Azad, A.K, Jahan, K, Sathi, T.S., Sultana, R, Abbas, Syed A
Format:	Article
Language:	English
Published:	2018
Subjects:	QD Chemistry RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/66403/ http://irep.iium.edu.my/66403/1/Dr.%20Helal-JDDT_Published%20article.pdf

id	iium-66403
recordtype	eprints
spelling	iium-664032018-10-02T09:54:42Z http://irep.iium.edu.my/66403/ Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion Helal Uddin, Abul Bashar Mohammed Azad, A.K Jahan, K Sathi, T.S. Sultana, R Abbas, Syed A QD Chemistry RS Pharmacy and materia medica Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. This technology is useful for enhancing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms. Albendazole is a broad-spectrum antihelmintic agent used for the treatment of a variety of parasitic worm infestations. It is practically insoluble in water but slightly soluble in solvents like chloroform, methanol, ethyl acetate, and acetonitrile. The aim of our study was to improve the dissolution profile of albendazole using HPMC K 100 LV, Kollidon VA64 and Mannitol as carriers by solid dispersion techniques. From the prepared solid dispersion, formulation code CSF5 showed better result where carrier was HMPC K 100 LV at 1:10 ratio in solvent evaporation method. The HPMC K 100 LV showed better result for both kneading and solvent evaporation methods. Moreover, among the method employed, solvent evaporation method showed better solubility of drug at 60 min also at 1:10 ratio which was 78.86%. Results indicated that current formulation of solid dispersion is a promising approach for enhancing drug solubility and dissolution. 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66403/1/Dr.%20Helal-JDDT_Published%20article.pdf Helal Uddin, Abul Bashar Mohammed and Azad, A.K and Jahan, K and Sathi, T.S. and Sultana, R and Abbas, Syed A (2018) Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion. Journal of Drug Delivery and Therapeutics. pp. 475-480. ISSN 2250-1177
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry RS Pharmacy and materia medica
spellingShingle	QD Chemistry RS Pharmacy and materia medica Helal Uddin, Abul Bashar Mohammed Azad, A.K Jahan, K Sathi, T.S. Sultana, R Abbas, Syed A Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
description	Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. This technology is useful for enhancing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms. Albendazole is a broad-spectrum antihelmintic agent used for the treatment of a variety of parasitic worm infestations. It is practically insoluble in water but slightly soluble in solvents like chloroform, methanol, ethyl acetate, and acetonitrile. The aim of our study was to improve the dissolution profile of albendazole using HPMC K 100 LV, Kollidon VA64 and Mannitol as carriers by solid dispersion techniques. From the prepared solid dispersion, formulation code CSF5 showed better result where carrier was HMPC K 100 LV at 1:10 ratio in solvent evaporation method. The HPMC K 100 LV showed better result for both kneading and solvent evaporation methods. Moreover, among the method employed, solvent evaporation method showed better solubility of drug at 60 min also at 1:10 ratio which was 78.86%. Results indicated that current formulation of solid dispersion is a promising approach for enhancing drug solubility and dissolution.
format	Article
author	Helal Uddin, Abul Bashar Mohammed Azad, A.K Jahan, K Sathi, T.S. Sultana, R Abbas, Syed A
author_facet	Helal Uddin, Abul Bashar Mohammed Azad, A.K Jahan, K Sathi, T.S. Sultana, R Abbas, Syed A
author_sort	Helal Uddin, Abul Bashar Mohammed
title	Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
title_short	Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
title_full	Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
title_fullStr	Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
title_full_unstemmed	Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
title_sort	improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
publishDate	2018
url	http://irep.iium.edu.my/66403/ http://irep.iium.edu.my/66403/1/Dr.%20Helal-JDDT_Published%20article.pdf
first_indexed	2023-09-18T21:34:16Z
last_indexed	2023-09-18T21:34:16Z
_version_	1777412715105484800

Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion

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