A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population

A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population

Evidence suggests that several genes; including Myo1H, play an important role in the etiology of Class III malocclusion. Single nucleotide polymorphism (SNP) in marker rs10850110 (locus 12q24.11) within Myo1H gene has been associated with the incidence of mandibular prognathism (MP). MYO1H is a clas...

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Main Authors: Yahya, Siti Nazirah, Abdul Razak, Nurul Syafiqah, Mokhtar@Makhtar, Khairani Idah, Abu Bakar, Noraini
Format: Article
Language:English
English
Published: Ectodermal Dysplasia Group 2018
Subjects:
RK Dentistry
Online Access:http://irep.iium.edu.my/66296/
http://irep.iium.edu.my/66296/
http://irep.iium.edu.my/66296/1/66296_A%20Preliminary%20Study%20on%20MYO1H%20Single%20Nucleotide_article.pdf
http://irep.iium.edu.my/66296/7/66296_A%20preliminary%20study%20on%20MYO1H%20single%20nucleotide%20polymorphism_SCOPUS.pdf
id iium-66296
recordtype eprints
spelling iium-662962019-10-29T08:19:51Z http://irep.iium.edu.my/66296/ A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population Yahya, Siti Nazirah Abdul Razak, Nurul Syafiqah Mokhtar@Makhtar, Khairani Idah Abu Bakar, Noraini RK Dentistry Evidence suggests that several genes; including Myo1H, play an important role in the etiology of Class III malocclusion. Single nucleotide polymorphism (SNP) in marker rs10850110 (locus 12q24.11) within Myo1H gene has been associated with the incidence of mandibular prognathism (MP). MYO1H is a class 1 myosin which has been implicated in various motile processes including cytoskeleton reorganization. Therefore, genetic alteration in genes responsible for muscle function will also affect the skeletal growth. This study aimed to detect the presence of Myo1H (rs10850110) SNP and to determine its genotype and allele distribution in MP patient in the local population. The sample comprises of 31 patients; 14 patients from class I malocclusion (control samples) and 17 patients from class III malocclusion (MP). Cephalometric measurements were performed prior to saliva samples collection. The DNA was amplified using the specific primers for the marker rs10850110 and the genotyping was done by sequencing. Chi-square test was used to determine the over-representation of marker allele (p<0.05). Presence of Myo1H SNP (rs10850110) was detected in local population analysed and the distribution of its genotype and allele could be observed. There were significant differences between allele (p=0.000) and genotype (p=0.000) frequency within and between control (Class I) and Class III malocclusion. Our findings are in agreement with previous studies suggesting positive influence of Myo1H (rs10850110) SNP in the incidence of MP. Further studies should be developed in order to understand the exact role and mechanism of Myo1H in different classes of malocclusions. Clinical article (J Int Dent Med Res 2018; 11(2): pp. 607-613) Ectodermal Dysplasia Group 2018-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66296/1/66296_A%20Preliminary%20Study%20on%20MYO1H%20Single%20Nucleotide_article.pdf application/pdf en http://irep.iium.edu.my/66296/7/66296_A%20preliminary%20study%20on%20MYO1H%20single%20nucleotide%20polymorphism_SCOPUS.pdf Yahya, Siti Nazirah and Abdul Razak, Nurul Syafiqah and Mokhtar@Makhtar, Khairani Idah and Abu Bakar, Noraini (2018) A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population. Journal of International Dental and Medical Research, 11 (2). pp. 607-613. ISSN 1309-100X http://www.jidmr.com/journal/wp-content/uploads/2018/09/41D18_580_Noraini_Abu_Bakar.pdf
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic RK Dentistry
spellingShingle RK Dentistry
Yahya, Siti Nazirah
Abdul Razak, Nurul Syafiqah
Mokhtar@Makhtar, Khairani Idah
Abu Bakar, Noraini
A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population
description Evidence suggests that several genes; including Myo1H, play an important role in the etiology of Class III malocclusion. Single nucleotide polymorphism (SNP) in marker rs10850110 (locus 12q24.11) within Myo1H gene has been associated with the incidence of mandibular prognathism (MP). MYO1H is a class 1 myosin which has been implicated in various motile processes including cytoskeleton reorganization. Therefore, genetic alteration in genes responsible for muscle function will also affect the skeletal growth. This study aimed to detect the presence of Myo1H (rs10850110) SNP and to determine its genotype and allele distribution in MP patient in the local population. The sample comprises of 31 patients; 14 patients from class I malocclusion (control samples) and 17 patients from class III malocclusion (MP). Cephalometric measurements were performed prior to saliva samples collection. The DNA was amplified using the specific primers for the marker rs10850110 and the genotyping was done by sequencing. Chi-square test was used to determine the over-representation of marker allele (p<0.05). Presence of Myo1H SNP (rs10850110) was detected in local population analysed and the distribution of its genotype and allele could be observed. There were significant differences between allele (p=0.000) and genotype (p=0.000) frequency within and between control (Class I) and Class III malocclusion. Our findings are in agreement with previous studies suggesting positive influence of Myo1H (rs10850110) SNP in the incidence of MP. Further studies should be developed in order to understand the exact role and mechanism of Myo1H in different classes of malocclusions. Clinical article (J Int Dent Med Res 2018; 11(2): pp. 607-613)
format Article
author Yahya, Siti Nazirah
Abdul Razak, Nurul Syafiqah
Mokhtar@Makhtar, Khairani Idah
Abu Bakar, Noraini
author_facet Yahya, Siti Nazirah
Abdul Razak, Nurul Syafiqah
Mokhtar@Makhtar, Khairani Idah
Abu Bakar, Noraini
author_sort Yahya, Siti Nazirah
title A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population
title_short A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population
title_full A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population
title_fullStr A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population
title_full_unstemmed A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population
title_sort preliminary study on myo1h single nucleotide polymorphism (rs10850110) in mandibular prognathism in malay population
publisher Ectodermal Dysplasia Group
publishDate 2018
url http://irep.iium.edu.my/66296/
http://irep.iium.edu.my/66296/
http://irep.iium.edu.my/66296/1/66296_A%20Preliminary%20Study%20on%20MYO1H%20Single%20Nucleotide_article.pdf
http://irep.iium.edu.my/66296/7/66296_A%20preliminary%20study%20on%20MYO1H%20single%20nucleotide%20polymorphism_SCOPUS.pdf
first_indexed 2023-09-18T21:34:07Z
last_indexed 2023-09-18T21:34:07Z
_version_ 1777412705744846848

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