Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility

Oil/water emulsion solvent evaporation method was employed to fabricate PCL microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system and gelatin. The porous network channels were generated inside the microcarrier by introducing camphene. The average pore size of...

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Main Authors:	Samsudin, Nurhusna, Hashim, Yumi Zuhanis Has-Yun, Arifin, Mohd Azmir, Mel, Maizirwan, Mohd. Salleh, Hamzah
Format:	Conference or Workshop Item
Language:	English English
Published:	International Institute for Halal Research and Training (INHART), IIUM 2018
Subjects:	Q Science (General) TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/66282/ http://irep.iium.edu.my/66282/ http://irep.iium.edu.my/66282/1/Conf-Samsudin%20et%20al%20%28iCHIPS%202018%29.pdf http://irep.iium.edu.my/66282/6/66282.pdf

id	iium-66282
recordtype	eprints
spelling	iium-662822020-01-30T04:19:23Z http://irep.iium.edu.my/66282/ Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility Samsudin, Nurhusna Hashim, Yumi Zuhanis Has-Yun Arifin, Mohd Azmir Mel, Maizirwan Mohd. Salleh, Hamzah Q Science (General) TP248.13 Biotechnology Oil/water emulsion solvent evaporation method was employed to fabricate PCL microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system and gelatin. The porous network channels were generated inside the microcarrier by introducing camphene. The average pore size of 11.74±8.32 μm was obtained with the concentration of 20% (w/v) of camphene. The porous PCL microcarrier was further tailored with gelatin through surface treatment with UV/O3 system and gelatin immobilization. Vero cells attach and proliferate well on the gelatin coated porous PCL microcarrier with maximum cell number of 3.90 x 105 cells/ml as compared to cell proliferation on UV/O3 treated porous PCL microcarrier (1.83 x 105 cells/ml). The developed halal microcarrier may be potentially applicable as a cell delivery scaffold for cell tissue culture and tissue engineering application International Institute for Halal Research and Training (INHART), IIUM 2018 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/66282/1/Conf-Samsudin%20et%20al%20%28iCHIPS%202018%29.pdf application/pdf en http://irep.iium.edu.my/66282/6/66282.pdf Samsudin, Nurhusna and Hashim, Yumi Zuhanis Has-Yun and Arifin, Mohd Azmir and Mel, Maizirwan and Mohd. Salleh, Hamzah (2018) Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility. In: International Conference on Halal Innovation in Products and Services 2018 (i-CHIPS 2018), 13th-14th July 2018, Haat Yai, Songkhla, Thailand. http://halalinst.psu.ac.th/i-chips/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General) TP248.13 Biotechnology
spellingShingle	Q Science (General) TP248.13 Biotechnology Samsudin, Nurhusna Hashim, Yumi Zuhanis Has-Yun Arifin, Mohd Azmir Mel, Maizirwan Mohd. Salleh, Hamzah Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility
description	Oil/water emulsion solvent evaporation method was employed to fabricate PCL microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system and gelatin. The porous network channels were generated inside the microcarrier by introducing camphene. The average pore size of 11.74±8.32 μm was obtained with the concentration of 20% (w/v) of camphene. The porous PCL microcarrier was further tailored with gelatin through surface treatment with UV/O3 system and gelatin immobilization. Vero cells attach and proliferate well on the gelatin coated porous PCL microcarrier with maximum cell number of 3.90 x 105 cells/ml as compared to cell proliferation on UV/O3 treated porous PCL microcarrier (1.83 x 105 cells/ml). The developed halal microcarrier may be potentially applicable as a cell delivery scaffold for cell tissue culture and tissue engineering application
format	Conference or Workshop Item
author	Samsudin, Nurhusna Hashim, Yumi Zuhanis Has-Yun Arifin, Mohd Azmir Mel, Maizirwan Mohd. Salleh, Hamzah
author_facet	Samsudin, Nurhusna Hashim, Yumi Zuhanis Has-Yun Arifin, Mohd Azmir Mel, Maizirwan Mohd. Salleh, Hamzah
author_sort	Samsudin, Nurhusna
title	Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility
title_short	Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility
title_full	Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility
title_fullStr	Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility
title_full_unstemmed	Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility
title_sort	surface modification of microporous polycaprolactone (pcl) microcarrier to improve microcarrier biocompatibility
publisher	International Institute for Halal Research and Training (INHART), IIUM
publishDate	2018
url	http://irep.iium.edu.my/66282/ http://irep.iium.edu.my/66282/ http://irep.iium.edu.my/66282/1/Conf-Samsudin%20et%20al%20%28iCHIPS%202018%29.pdf http://irep.iium.edu.my/66282/6/66282.pdf
first_indexed	2023-09-18T21:34:05Z
last_indexed	2023-09-18T21:34:05Z
_version_	1777412704265306112

Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility

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