Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility
Oil/water emulsion solvent evaporation method was employed to fabricate PCL microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system and gelatin. The porous network channels were generated inside the microcarrier by introducing camphene. The average pore size of...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
International Institute for Halal Research and Training (INHART), IIUM
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/66282/ http://irep.iium.edu.my/66282/ http://irep.iium.edu.my/66282/1/Conf-Samsudin%20et%20al%20%28iCHIPS%202018%29.pdf http://irep.iium.edu.my/66282/6/66282.pdf |
| Summary: | Oil/water emulsion solvent evaporation method was employed to fabricate PCL
microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system
and gelatin. The porous network channels were generated inside the microcarrier by
introducing camphene. The average pore size of 11.74±8.32 μm was obtained with the
concentration of 20% (w/v) of camphene. The porous PCL microcarrier was further tailored
with gelatin through surface treatment with UV/O3 system and gelatin immobilization. Vero
cells attach and proliferate well on the gelatin coated porous PCL microcarrier with maximum
cell number of 3.90 x 105
cells/ml as compared to cell proliferation on UV/O3 treated porous
PCL microcarrier (1.83 x 105 cells/ml). The developed halal microcarrier may be potentially
applicable as a cell delivery scaffold for cell tissue culture and tissue engineering application |
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