Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants

Local drug delivery using drug-releasing implants located inside bone is recognised as a promising strategy to address the limitations of systemic drug administration to bone. However, the studies of drug-release kinetics are not possible to perform using existing in-vitro drug releasing systems and...

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Main Authors:	Kaiser, J, Buenzi, PR, Moom, Sin Aw, Khalid, Kamarul Ariffin, Gulati, Karan, Atkins, Gerald J, Pivonka, Peter, Findlay, David M, Losic, Dusan
Format:	Conference or Workshop Item
Language:	English
Published:	2012
Subjects:	R Medicine (General) RD701 Orthopedics T Technology (General)
Online Access:	http://irep.iium.edu.my/66163/ http://irep.iium.edu.my/66163/27/66163%20%20Computational%20and%20experimental%20characterization.pdf

id	iium-66163
recordtype	eprints
spelling	iium-661632018-10-04T04:29:59Z http://irep.iium.edu.my/66163/ Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants Kaiser, J Buenzi, PR Moom, Sin Aw Khalid, Kamarul Ariffin Gulati, Karan Atkins, Gerald J Pivonka, Peter Findlay, David M Losic, Dusan R Medicine (General) RD701 Orthopedics T Technology (General) Local drug delivery using drug-releasing implants located inside bone is recognised as a promising strategy to address the limitations of systemic drug administration to bone. However, the studies of drug-release kinetics are not possible to perform using existing in-vitro drug releasing systems and 2-D bone cell models. The aim of this work is to demonstrate the use of a 3-D bone bioreactor for studying the drug-release kinetics and distribution of drugs in the ex-vivo cancellous bone environment. Bovine trabecular bone was used as the bone substrate, in which drug-releasing implants were embedded in the form of nano-engineered titanium wires covered with a layer of titania nanotube (TNT) arrays. A hydrophilic fluorescent dye (rhodamine B) was used as a model drug, loaded inside the TNT/Ti implants to monitor drug release and transport in trabecular bone under ex-vivo conditions. In order to better understand how the bioreactor perfusion rate and the local drug release from the titanium wire affect overall drug distribution in the bone sample we utilize 3D finite element modelling. This model is based on porous media theory and takes into account advective-diffusive transport of the drug through the micropores of bone. The results showed a consistent, gradual release of model drug from the TNT/Ti implants, with a characteristic three-dimensional distribution into the surrounding bone over a period of 5 days. These results demonstrate the utility of this system for ex-vivo drug release studies in bone, which can be applied to optimise the administration therapeutics in bone for specific therapies and design of new drug delivery systems. 2012 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/66163/27/66163%20%20Computational%20and%20experimental%20characterization.pdf Kaiser, J and Buenzi, PR and Moom, Sin Aw and Khalid, Kamarul Ariffin and Gulati, Karan and Atkins, Gerald J and Pivonka, Peter and Findlay, David M and Losic, Dusan (2012) Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants. In: 1st Asia Pacific Bone and Mineral Research Meeting and the Australian & New Zealand Bone & Mineral Society 22nd Annual Scientific Meeting, 2nd - 5th September 2012, Perth, Australia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RD701 Orthopedics T Technology (General)
spellingShingle	R Medicine (General) RD701 Orthopedics T Technology (General) Kaiser, J Buenzi, PR Moom, Sin Aw Khalid, Kamarul Ariffin Gulati, Karan Atkins, Gerald J Pivonka, Peter Findlay, David M Losic, Dusan Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants
description	Local drug delivery using drug-releasing implants located inside bone is recognised as a promising strategy to address the limitations of systemic drug administration to bone. However, the studies of drug-release kinetics are not possible to perform using existing in-vitro drug releasing systems and 2-D bone cell models. The aim of this work is to demonstrate the use of a 3-D bone bioreactor for studying the drug-release kinetics and distribution of drugs in the ex-vivo cancellous bone environment. Bovine trabecular bone was used as the bone substrate, in which drug-releasing implants were embedded in the form of nano-engineered titanium wires covered with a layer of titania nanotube (TNT) arrays. A hydrophilic fluorescent dye (rhodamine B) was used as a model drug, loaded inside the TNT/Ti implants to monitor drug release and transport in trabecular bone under ex-vivo conditions. In order to better understand how the bioreactor perfusion rate and the local drug release from the titanium wire affect overall drug distribution in the bone sample we utilize 3D finite element modelling. This model is based on porous media theory and takes into account advective-diffusive transport of the drug through the micropores of bone. The results showed a consistent, gradual release of model drug from the TNT/Ti implants, with a characteristic three-dimensional distribution into the surrounding bone over a period of 5 days. These results demonstrate the utility of this system for ex-vivo drug release studies in bone, which can be applied to optimise the administration therapeutics in bone for specific therapies and design of new drug delivery systems.
format	Conference or Workshop Item
author	Kaiser, J Buenzi, PR Moom, Sin Aw Khalid, Kamarul Ariffin Gulati, Karan Atkins, Gerald J Pivonka, Peter Findlay, David M Losic, Dusan
author_facet	Kaiser, J Buenzi, PR Moom, Sin Aw Khalid, Kamarul Ariffin Gulati, Karan Atkins, Gerald J Pivonka, Peter Findlay, David M Losic, Dusan
author_sort	Kaiser, J
title	Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants
title_short	Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants
title_full	Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants
title_fullStr	Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants
title_full_unstemmed	Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants
title_sort	computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants
publishDate	2012
url	http://irep.iium.edu.my/66163/ http://irep.iium.edu.my/66163/27/66163%20%20Computational%20and%20experimental%20characterization.pdf
first_indexed	2023-09-18T21:33:53Z
last_indexed	2023-09-18T21:33:53Z
_version_	1777412691407667200

Computational and experimental characterization of drug release kinetics in trabecular bone from titania nanotube implants

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