The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study

Flaxseed is a natural product with a wide array of anticancer, antibacterial, antiviral and also antifungal properties. Flaxseed extracts; either oil or water based can be incorporated into pharmaceutical compounds to be used in clinical setting. This study aims to compare the in-vitro antifungal ef...

Full description

Bibliographic Details
Main Authors:	Mustafa Al-Ahmad, Basma Ezzat, Subramaniam, Pram Kumar, Mustafa, Nazih Shaban, Kashmola, Muhanad Ali Hamdon, Mokhtar@Makhtar, Khairani Idah, Qaralleh, Haitham
Format:	Article
Language:	English English
Published:	Ektodermal Displazi Grubu 2018
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/66005/ http://irep.iium.edu.my/66005/ http://irep.iium.edu.my/66005/1/36D18_578-Layout.pdf http://irep.iium.edu.my/66005/7/66005_The%20anti-fungal%20effect%20of%20flax%20seed%20on%20oral%20candidiasis_SCOPUS.pdf

id	iium-66005
recordtype	eprints
spelling	iium-660052019-10-29T08:31:38Z http://irep.iium.edu.my/66005/ The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study Mustafa Al-Ahmad, Basma Ezzat Subramaniam, Pram Kumar Mustafa, Nazih Shaban Kashmola, Muhanad Ali Hamdon Mokhtar@Makhtar, Khairani Idah Qaralleh, Haitham RK Dentistry Flaxseed is a natural product with a wide array of anticancer, antibacterial, antiviral and also antifungal properties. Flaxseed extracts; either oil or water based can be incorporated into pharmaceutical compounds to be used in clinical setting. This study aims to compare the in-vitro antifungal effectiveness of flaxseed extract against the commonly used synthetic compound, Nystatin. Methodically, antifungal effectiveness of flaxseed extract and Nystatin was tested upon the Candida albicans culture growth in petri dishes. Disc diffusion method was performed and the zones of inhibition around the disc within each petri dish were measured after 48 hours of incubation period. Oil-based and water-based flaxseed extract types were evaluated using disc diffusion method at different volume per disc (5μl, 10μl and 15μl) and its result was compared to Nystatin's effectiveness. The principle result shows that the oil-based extract exhibited no antifungal activity despite of the increasing quantity used. Interestingly the comparison of mean value for candidal growth inhibition diameter between flaxseed aqueous extract and Nystatin was significant based on p-value less than 0.05. Clearly, Candida albicans growth diameter mean value was greater with higher increment of flaxseed aqueous extract when compared to the Nystatin 100 units control test. The greatest zone of inhibition was seen with 15μl of flaxseed aqueous extract. Thus, water-based flaxseed extract has a great potential to be used as a clinical product to control oral fungal infection while eliminating the unwanted side effects commonly occurring with synthetic products. Ektodermal Displazi Grubu 2018-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66005/1/36D18_578-Layout.pdf application/pdf en http://irep.iium.edu.my/66005/7/66005_The%20anti-fungal%20effect%20of%20flax%20seed%20on%20oral%20candidiasis_SCOPUS.pdf Mustafa Al-Ahmad, Basma Ezzat and Subramaniam, Pram Kumar and Mustafa, Nazih Shaban and Kashmola, Muhanad Ali Hamdon and Mokhtar@Makhtar, Khairani Idah and Qaralleh, Haitham (2018) The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study. Journal of International Dental and Medical Research, 11 (2). pp. 580-586. ISSN 1309-100X http://www.jidmr.com/journal/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RK Dentistry
spellingShingle	RK Dentistry Mustafa Al-Ahmad, Basma Ezzat Subramaniam, Pram Kumar Mustafa, Nazih Shaban Kashmola, Muhanad Ali Hamdon Mokhtar@Makhtar, Khairani Idah Qaralleh, Haitham The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study
description	Flaxseed is a natural product with a wide array of anticancer, antibacterial, antiviral and also antifungal properties. Flaxseed extracts; either oil or water based can be incorporated into pharmaceutical compounds to be used in clinical setting. This study aims to compare the in-vitro antifungal effectiveness of flaxseed extract against the commonly used synthetic compound, Nystatin. Methodically, antifungal effectiveness of flaxseed extract and Nystatin was tested upon the Candida albicans culture growth in petri dishes. Disc diffusion method was performed and the zones of inhibition around the disc within each petri dish were measured after 48 hours of incubation period. Oil-based and water-based flaxseed extract types were evaluated using disc diffusion method at different volume per disc (5μl, 10μl and 15μl) and its result was compared to Nystatin's effectiveness. The principle result shows that the oil-based extract exhibited no antifungal activity despite of the increasing quantity used. Interestingly the comparison of mean value for candidal growth inhibition diameter between flaxseed aqueous extract and Nystatin was significant based on p-value less than 0.05. Clearly, Candida albicans growth diameter mean value was greater with higher increment of flaxseed aqueous extract when compared to the Nystatin 100 units control test. The greatest zone of inhibition was seen with 15μl of flaxseed aqueous extract. Thus, water-based flaxseed extract has a great potential to be used as a clinical product to control oral fungal infection while eliminating the unwanted side effects commonly occurring with synthetic products.
format	Article
author	Mustafa Al-Ahmad, Basma Ezzat Subramaniam, Pram Kumar Mustafa, Nazih Shaban Kashmola, Muhanad Ali Hamdon Mokhtar@Makhtar, Khairani Idah Qaralleh, Haitham
author_facet	Mustafa Al-Ahmad, Basma Ezzat Subramaniam, Pram Kumar Mustafa, Nazih Shaban Kashmola, Muhanad Ali Hamdon Mokhtar@Makhtar, Khairani Idah Qaralleh, Haitham
author_sort	Mustafa Al-Ahmad, Basma Ezzat
title	The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study
title_short	The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study
title_full	The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study
title_fullStr	The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study
title_full_unstemmed	The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study
title_sort	anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study
publisher	Ektodermal Displazi Grubu
publishDate	2018
url	http://irep.iium.edu.my/66005/ http://irep.iium.edu.my/66005/ http://irep.iium.edu.my/66005/1/36D18_578-Layout.pdf http://irep.iium.edu.my/66005/7/66005_The%20anti-fungal%20effect%20of%20flax%20seed%20on%20oral%20candidiasis_SCOPUS.pdf
first_indexed	2023-09-18T21:33:40Z
last_indexed	2023-09-18T21:33:40Z
_version_	1777412677885231104

The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study

Similar Items