Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)

Chronic kidney disease (CKD) is commonly associated with disorders of mineral and bone metabolism, manifested by either one or a combination of the following three components namely : Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and vitamin D...

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Main Author:	Wan Ali, Wan Ahmad Syahril Rozli
Format:	Conference or Workshop Item
Language:	English English
Published:	2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/65455/ http://irep.iium.edu.my/65455/1/CKD%20MBD%20ZENITH.pdf http://irep.iium.edu.my/65455/2/6FB5B9F3-B804-4107-9F6A-202474133357.jpeg

id	iium-65455
recordtype	eprints
spelling	iium-654552018-09-06T06:58:30Z http://irep.iium.edu.my/65455/ Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD) Wan Ali, Wan Ahmad Syahril Rozli R Medicine (General) Chronic kidney disease (CKD) is commonly associated with disorders of mineral and bone metabolism, manifested by either one or a combination of the following three components namely : Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and vitamin D metabolism; Abnormalities in bone turnover, mineralization, volume linear growth, or strength; and Extraskeletal calcification. This topic reviews the pathogenesis of CKD-MBD. The pathophysiology of the disorder is complex and involves a number of feedback loops between the kidney, bone, intestine, and the vasculature. The main goal of this system is maintenance of calcium and phosphorus balance, often at the expense of abnormalities in other components of the system. While most elements of CKD–MBD are usually present when the glomerular filtration rate (GFR) falls below 40 mL/min, some components may be observed earlier in the course of CKD and precede the onset of clinically detectable abnormalities in serum phosphorus, calcium, PTH, and vitamin D. These include decreased bone formation rates, vascular calcification, loss of klotho, and increased FGF23 secretion. 2018-07-15 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/65455/1/CKD%20MBD%20ZENITH.pdf application/pdf en http://irep.iium.edu.my/65455/2/6FB5B9F3-B804-4107-9F6A-202474133357.jpeg Wan Ali, Wan Ahmad Syahril Rozli (2018) Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD). In: Kuantan CKD-MBD Workshop 2018, 15th July 2018, The Zenith Hotel Kuantan. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Wan Ali, Wan Ahmad Syahril Rozli Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)
description	Chronic kidney disease (CKD) is commonly associated with disorders of mineral and bone metabolism, manifested by either one or a combination of the following three components namely : Abnormalities of calcium, phosphorus, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and vitamin D metabolism; Abnormalities in bone turnover, mineralization, volume linear growth, or strength; and Extraskeletal calcification. This topic reviews the pathogenesis of CKD-MBD. The pathophysiology of the disorder is complex and involves a number of feedback loops between the kidney, bone, intestine, and the vasculature. The main goal of this system is maintenance of calcium and phosphorus balance, often at the expense of abnormalities in other components of the system. While most elements of CKD–MBD are usually present when the glomerular filtration rate (GFR) falls below 40 mL/min, some components may be observed earlier in the course of CKD and precede the onset of clinically detectable abnormalities in serum phosphorus, calcium, PTH, and vitamin D. These include decreased bone formation rates, vascular calcification, loss of klotho, and increased FGF23 secretion.
format	Conference or Workshop Item
author	Wan Ali, Wan Ahmad Syahril Rozli
author_facet	Wan Ali, Wan Ahmad Syahril Rozli
author_sort	Wan Ali, Wan Ahmad Syahril Rozli
title	Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)
title_short	Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)
title_full	Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)
title_fullStr	Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)
title_full_unstemmed	Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)
title_sort	understanding chronic kidney disease- mineral bone disorder (ckd-mbd)
publishDate	2018
url	http://irep.iium.edu.my/65455/ http://irep.iium.edu.my/65455/1/CKD%20MBD%20ZENITH.pdf http://irep.iium.edu.my/65455/2/6FB5B9F3-B804-4107-9F6A-202474133357.jpeg
first_indexed	2023-09-18T21:32:53Z
last_indexed	2023-09-18T21:32:53Z
_version_	1777412628133445632

Understanding Chronic Kidney Disease- Mineral Bone Disorder (CKD-MBD)

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