Development of porous PCL-based microcarrier

Polycaprolactone (PCL) has been used for cell cultivation due to its biocompatibility. However, fabrication of porous PCL microcarrier was an obstacle and study of its biodegradability is also limited. In the present study, PCL-based porous microcarrier was fabricated with different parameters by us...

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Main Authors:	Mohd. Salleh, Hamzah, Hashim, Yumi Zuhanis Has-Yun, Samsudin, Nurhusna, Abdul Halim, Muhammad A. N.
Format:	Conference or Workshop Item
Language:	English
Published:	International Institute for Halal research and Training (INHART), IIUM 2018
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/65249/ http://irep.iium.edu.my/65249/ http://irep.iium.edu.my/65249/1/65249_Development%20of%20Porous%20PCL-based.pdf

id	iium-65249
recordtype	eprints
spelling	iium-652492019-01-04T07:46:11Z http://irep.iium.edu.my/65249/ Development of porous PCL-based microcarrier Mohd. Salleh, Hamzah Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Abdul Halim, Muhammad A. N. TP248.13 Biotechnology Polycaprolactone (PCL) has been used for cell cultivation due to its biocompatibility. However, fabrication of porous PCL microcarrier was an obstacle and study of its biodegradability is also limited. In the present study, PCL-based porous microcarrier was fabricated with different parameters by using emulsion evaporation method. From the study, at 20% camphene concentration, optimum pore size was generated which was at 11.738 μm. During the fabrication of the microcarrier, most of the parameters showed effect on the size of the microcarrier. Under the biodegradability test, it showed that the porous structure of the microcarrier enhance the degradation rate of the microcarrier. Throughout the study, all the parameters tested for the fabrication of microcarrier showed effect on it and the porous structure improve the degradation rate of PCL microcarrier. International Institute for Halal research and Training (INHART), IIUM 2018 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/65249/1/65249_Development%20of%20Porous%20PCL-based.pdf Mohd. Salleh, Hamzah and Hashim, Yumi Zuhanis Has-Yun and Samsudin, Nurhusna and Abdul Halim, Muhammad A. N. (2018) Development of porous PCL-based microcarrier. In: International Conference on Halal Innovation in Products and Services 2018 (i-CHIPS 2018), 13th-14th July 2018, Haat Yai, Songkhla, Thailand. http://halalinst.psu.ac.th/i-chips/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Mohd. Salleh, Hamzah Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Abdul Halim, Muhammad A. N. Development of porous PCL-based microcarrier
description	Polycaprolactone (PCL) has been used for cell cultivation due to its biocompatibility. However, fabrication of porous PCL microcarrier was an obstacle and study of its biodegradability is also limited. In the present study, PCL-based porous microcarrier was fabricated with different parameters by using emulsion evaporation method. From the study, at 20% camphene concentration, optimum pore size was generated which was at 11.738 μm. During the fabrication of the microcarrier, most of the parameters showed effect on the size of the microcarrier. Under the biodegradability test, it showed that the porous structure of the microcarrier enhance the degradation rate of the microcarrier. Throughout the study, all the parameters tested for the fabrication of microcarrier showed effect on it and the porous structure improve the degradation rate of PCL microcarrier.
format	Conference or Workshop Item
author	Mohd. Salleh, Hamzah Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Abdul Halim, Muhammad A. N.
author_facet	Mohd. Salleh, Hamzah Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Abdul Halim, Muhammad A. N.
author_sort	Mohd. Salleh, Hamzah
title	Development of porous PCL-based microcarrier
title_short	Development of porous PCL-based microcarrier
title_full	Development of porous PCL-based microcarrier
title_fullStr	Development of porous PCL-based microcarrier
title_full_unstemmed	Development of porous PCL-based microcarrier
title_sort	development of porous pcl-based microcarrier
publisher	International Institute for Halal research and Training (INHART), IIUM
publishDate	2018
url	http://irep.iium.edu.my/65249/ http://irep.iium.edu.my/65249/ http://irep.iium.edu.my/65249/1/65249_Development%20of%20Porous%20PCL-based.pdf
first_indexed	2023-09-18T21:32:35Z
last_indexed	2023-09-18T21:32:35Z
_version_	1777412609629224960

Development of porous PCL-based microcarrier

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