Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model

The aim of this review was to summarize and discuss the patterns and trends of the combination of cartilage tissue engineering and gene transfer approaches in in vivo preclinical (or, animal) studies. Electronic literature search of articles published in the Web of Science (WOS) and SCOPUS databases...

Full description

Bibliographic Details
Main Authors:	Mohamed Amin, Muhammad Azri Ifwat, Azhim, Azran, Mohamed Sideek, Mohamed Arshad, Zulkifly, Ahmad Hafiz, Sha'ban, Munirah
Format:	Article
Language:	English
Published:	Persatuan Genetik Malaysia (Genetics Society of Malaysia) 2017
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/64976/ http://irep.iium.edu.my/64976/ http://irep.iium.edu.my/64976/1/TPGM%207%20MAIMA.pdf

id	iium-64976
recordtype	eprints
spelling	iium-649762018-09-12T01:31:28Z http://irep.iium.edu.my/64976/ Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model Mohamed Amin, Muhammad Azri Ifwat Azhim, Azran Mohamed Sideek, Mohamed Arshad Zulkifly, Ahmad Hafiz Sha'ban, Munirah R Medicine (General) The aim of this review was to summarize and discuss the patterns and trends of the combination of cartilage tissue engineering and gene transfer approaches in in vivo preclinical (or, animal) studies. Electronic literature search of articles published in the Web of Science (WOS) and SCOPUS databases was done based on the following keywords: “tissue engineering”, “articular cartilage”, “animal OR vivo” and “gene”. Two levels of screening were used i.e. based on selected themes and full-text availability of the articles. Inclusion criteria were original full-text papers of preclinical studies using tissue engineering application and gene transfer strategy for articular cartilage regeneration. While, exclusion criteria were conference and review papers, and drug delivery based studies. The search yielded a total of 632 articles (WOS=211; SCOPUS=421). Out of 632, only 612 articles were selected after the removal of 20 overlapping articles from both WOS and SCOPUS databases. After further screening had completed, only 35 articles were included based on their relevancy to this study. Eight (8) articles were then excluded because full-text version of publications was not available. With that, only 27 articles left and included in this present review. The trend in animal studies shows the use of TGF-β (33.33%) and SOX9 (14.81%) transfections enhance chondrogenic differentiation, whilst TGF-β and ChM-1 (3.70%) maintain the chondrocytic phenotype. The co-transfection of TGF-β and BMP (40.74%) promote the integration between tissue engineered implant and the adjacent host cartilage in animal models. Other genes such as IGF-1 (7.41%), CTGF (3.70%) and Bcl-Xl (3.70%) have been reported to enhance cartilage regeneration. In conclusion, the use of genes transfer approach for cartilage tissue engineering in various animal models promotes articular cartilage regeneration which may be useful for future clinical setting. Persatuan Genetik Malaysia (Genetics Society of Malaysia) 2017-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64976/1/TPGM%207%20MAIMA.pdf Mohamed Amin, Muhammad Azri Ifwat and Azhim, Azran and Mohamed Sideek, Mohamed Arshad and Zulkifly, Ahmad Hafiz and Sha'ban, Munirah (2017) Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model. Transactions of the Persatuan Genetik Malaysia (TPGM) (7). pp. 201-210. ISSN 978–967–14943–4–9 (ISBN) E-ISSN 978–967–14943–7–0 (e-ISBN) https://www.pgm-my.org/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohamed Amin, Muhammad Azri Ifwat Azhim, Azran Mohamed Sideek, Mohamed Arshad Zulkifly, Ahmad Hafiz Sha'ban, Munirah Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model
description	The aim of this review was to summarize and discuss the patterns and trends of the combination of cartilage tissue engineering and gene transfer approaches in in vivo preclinical (or, animal) studies. Electronic literature search of articles published in the Web of Science (WOS) and SCOPUS databases was done based on the following keywords: “tissue engineering”, “articular cartilage”, “animal OR vivo” and “gene”. Two levels of screening were used i.e. based on selected themes and full-text availability of the articles. Inclusion criteria were original full-text papers of preclinical studies using tissue engineering application and gene transfer strategy for articular cartilage regeneration. While, exclusion criteria were conference and review papers, and drug delivery based studies. The search yielded a total of 632 articles (WOS=211; SCOPUS=421). Out of 632, only 612 articles were selected after the removal of 20 overlapping articles from both WOS and SCOPUS databases. After further screening had completed, only 35 articles were included based on their relevancy to this study. Eight (8) articles were then excluded because full-text version of publications was not available. With that, only 27 articles left and included in this present review. The trend in animal studies shows the use of TGF-β (33.33%) and SOX9 (14.81%) transfections enhance chondrogenic differentiation, whilst TGF-β and ChM-1 (3.70%) maintain the chondrocytic phenotype. The co-transfection of TGF-β and BMP (40.74%) promote the integration between tissue engineered implant and the adjacent host cartilage in animal models. Other genes such as IGF-1 (7.41%), CTGF (3.70%) and Bcl-Xl (3.70%) have been reported to enhance cartilage regeneration. In conclusion, the use of genes transfer approach for cartilage tissue engineering in various animal models promotes articular cartilage regeneration which may be useful for future clinical setting.
format	Article
author	Mohamed Amin, Muhammad Azri Ifwat Azhim, Azran Mohamed Sideek, Mohamed Arshad Zulkifly, Ahmad Hafiz Sha'ban, Munirah
author_facet	Mohamed Amin, Muhammad Azri Ifwat Azhim, Azran Mohamed Sideek, Mohamed Arshad Zulkifly, Ahmad Hafiz Sha'ban, Munirah
author_sort	Mohamed Amin, Muhammad Azri Ifwat
title	Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model
title_short	Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model
title_full	Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model
title_fullStr	Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model
title_full_unstemmed	Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model
title_sort	current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model
publisher	Persatuan Genetik Malaysia (Genetics Society of Malaysia)
publishDate	2017
url	http://irep.iium.edu.my/64976/ http://irep.iium.edu.my/64976/ http://irep.iium.edu.my/64976/1/TPGM%207%20MAIMA.pdf
first_indexed	2023-09-18T21:32:12Z
last_indexed	2023-09-18T21:32:12Z
_version_	1777412585644097536

Current trends in gene-enhanced tissue engineering for articular cartilage regeneration in animal model

Similar Items