The application of gene transfer technology in articular cartilage tissue engineering: An insight

Degenerative disease of osteoarthritis (OA) may be caused by untreated injury or trauma to articular cartilage. The use of gene transfer technology in conjunction with tissue engineering has been suggested as having the potential to treat cartilage injuries. The combination may even reverse the dege...

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Main Authors:	Ahmad Radzi, Muhammad Aa'zamuddin, Abdulahi Hashi, Abdurezak, Azhim, Azran, Sha'ban, Munirah
Format:	Article
Language:	English
Published:	Persatuan Genetik Malaysia (Genetics Society of Malaysia) 2017
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/64975/ http://irep.iium.edu.my/64975/ http://irep.iium.edu.my/64975/1/TPGM%207%20MAAR.pdf

id	iium-64975
recordtype	eprints
spelling	iium-649752018-09-12T01:50:09Z http://irep.iium.edu.my/64975/ The application of gene transfer technology in articular cartilage tissue engineering: An insight Ahmad Radzi, Muhammad Aa'zamuddin Abdulahi Hashi, Abdurezak Azhim, Azran Sha'ban, Munirah R Medicine (General) Degenerative disease of osteoarthritis (OA) may be caused by untreated injury or trauma to articular cartilage. The use of gene transfer technology in conjunction with tissue engineering has been suggested as having the potential to treat cartilage injuries. The combination may even reverse the degenerative changes that lead to OA. Various genes that are responsible for specific protein production that stimulate the regeneration and restoration of cartilage have been identified. This paper serves to fill the dearth of literature that examine the use of the combination of gene transfer technology and tissue engineering to address OA. This study explores the patterns and trends of publications that describe the application of gene transfer technology in articular cartilage tissue engineering (ACTE). Using selected terms, a search was conducted on the published articles indexed in Elsevier’s SCOPUS and Thomson Reuter’s Web of Science™ Core Collection related to gene transfer technology in ACTE. It can be appreciated that the number of publications related to the association of gene transfer technology and ACTE is low. The present findings suggest that ACTE has yet to fully utilize the gene transfer technology that introduces functional genes into the targeted cells. Among the most commonly used genes reported in the publications are Transforming Growth Factor-Beta 1 (TGF-β1), TGF-β3, Bone Morphogenetic Protein 2 (BMP-2), Interleukin-1 Receptor Antagonist (IL-1Ra), Sex Determining Region Y-box9 (SOX9), and Insulin-like Growth Factor I (IGF-I). The introduction of these functional genes was achieved by using either viral or non-viral gene delivery systems. It is hoped that further studies will be done to examine the potential application of gene transfer technology in ACTE. Their combination can be used for cartilage regeneration to treat osteoarthritic condition. Persatuan Genetik Malaysia (Genetics Society of Malaysia) 2017-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64975/1/TPGM%207%20MAAR.pdf Ahmad Radzi, Muhammad Aa'zamuddin and Abdulahi Hashi, Abdurezak and Azhim, Azran and Sha'ban, Munirah (2017) The application of gene transfer technology in articular cartilage tissue engineering: An insight. Transactions of the Persatuan Genetik Malaysia (TPGM) (7). pp. 211-216. ISSN 978–967–14943–4–9 E-ISSN 978–967–14943–7–0 https://www.pgm-my.org/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Ahmad Radzi, Muhammad Aa'zamuddin Abdulahi Hashi, Abdurezak Azhim, Azran Sha'ban, Munirah The application of gene transfer technology in articular cartilage tissue engineering: An insight
description	Degenerative disease of osteoarthritis (OA) may be caused by untreated injury or trauma to articular cartilage. The use of gene transfer technology in conjunction with tissue engineering has been suggested as having the potential to treat cartilage injuries. The combination may even reverse the degenerative changes that lead to OA. Various genes that are responsible for specific protein production that stimulate the regeneration and restoration of cartilage have been identified. This paper serves to fill the dearth of literature that examine the use of the combination of gene transfer technology and tissue engineering to address OA. This study explores the patterns and trends of publications that describe the application of gene transfer technology in articular cartilage tissue engineering (ACTE). Using selected terms, a search was conducted on the published articles indexed in Elsevier’s SCOPUS and Thomson Reuter’s Web of Science™ Core Collection related to gene transfer technology in ACTE. It can be appreciated that the number of publications related to the association of gene transfer technology and ACTE is low. The present findings suggest that ACTE has yet to fully utilize the gene transfer technology that introduces functional genes into the targeted cells. Among the most commonly used genes reported in the publications are Transforming Growth Factor-Beta 1 (TGF-β1), TGF-β3, Bone Morphogenetic Protein 2 (BMP-2), Interleukin-1 Receptor Antagonist (IL-1Ra), Sex Determining Region Y-box9 (SOX9), and Insulin-like Growth Factor I (IGF-I). The introduction of these functional genes was achieved by using either viral or non-viral gene delivery systems. It is hoped that further studies will be done to examine the potential application of gene transfer technology in ACTE. Their combination can be used for cartilage regeneration to treat osteoarthritic condition.
format	Article
author	Ahmad Radzi, Muhammad Aa'zamuddin Abdulahi Hashi, Abdurezak Azhim, Azran Sha'ban, Munirah
author_facet	Ahmad Radzi, Muhammad Aa'zamuddin Abdulahi Hashi, Abdurezak Azhim, Azran Sha'ban, Munirah
author_sort	Ahmad Radzi, Muhammad Aa'zamuddin
title	The application of gene transfer technology in articular cartilage tissue engineering: An insight
title_short	The application of gene transfer technology in articular cartilage tissue engineering: An insight
title_full	The application of gene transfer technology in articular cartilage tissue engineering: An insight
title_fullStr	The application of gene transfer technology in articular cartilage tissue engineering: An insight
title_full_unstemmed	The application of gene transfer technology in articular cartilage tissue engineering: An insight
title_sort	application of gene transfer technology in articular cartilage tissue engineering: an insight
publisher	Persatuan Genetik Malaysia (Genetics Society of Malaysia)
publishDate	2017
url	http://irep.iium.edu.my/64975/ http://irep.iium.edu.my/64975/ http://irep.iium.edu.my/64975/1/TPGM%207%20MAAR.pdf
first_indexed	2023-09-18T21:32:12Z
last_indexed	2023-09-18T21:32:12Z
_version_	1777412585506734080

The application of gene transfer technology in articular cartilage tissue engineering: An insight

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