Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product

Articular cartilage has poor repair capacity due to its avascular and aneural properties. To date, there is no definitive treatment that can delay or reverse the degenerative process in cartilage. Therefore this bioartificial articular cartilage substitute is one of the alternatives that employ es...

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Main Authors:	Abdul Rahman, Rozlin, Sha'ban, Munirah, Zulkifly, Ahmad Hafiz
Format:	Conference or Workshop Item
Language:	English English
Published:	2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/64956/ http://irep.iium.edu.my/64956/ http://irep.iium.edu.my/64956/1/ITEX18_POSTER.pdf http://irep.iium.edu.my/64956/7/IMG_20180806_0001.pdf

id	iium-64956
recordtype	eprints
spelling	iium-649562018-09-05T09:21:48Z http://irep.iium.edu.my/64956/ Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product Abdul Rahman, Rozlin Sha'ban, Munirah Zulkifly, Ahmad Hafiz R Medicine (General) Articular cartilage has poor repair capacity due to its avascular and aneural properties. To date, there is no definitive treatment that can delay or reverse the degenerative process in cartilage. Therefore this bioartificial articular cartilage substitute is one of the alternatives that employ essential tissue engineering triad, which consist of i) quality cell source i.e. autologous bone marrow mesenchymal stem cells (BMSCs), ii) biomaterial scaffolds i.e. synthetic poly(lactic-co-glycolic)acid (PLGA) [+] natural fibrin and iii) signalling factors (chemical and/or physical stimuli) i.e. selected growth medium. All threecomponents are combined together forming PLGA-based scaffolds and BMSCs to restore damaged joint cartilage. Our implant model demonstrated promising findings with satisfactory structural and functional cartilaginous tissue restoration based on the International Cartilage Repair Society (ICRS) classification and the modified O’Driscoll histological grading scale. This reliable autologous matrix-induced cartilage implantation system uses one’s own cells, therefore the approach can be used to bypass certain social and scientific issues surrounding the conventional tissue or organ transplantation. 2018-05 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/64956/1/ITEX18_POSTER.pdf application/pdf en http://irep.iium.edu.my/64956/7/IMG_20180806_0001.pdf Abdul Rahman, Rozlin and Sha'ban, Munirah and Zulkifly, Ahmad Hafiz (2018) Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product. In: International Invention, Innovation & Technology Exhibition (ITEX 2018), 10th-12th May 2018, Kuala Lumpur. (Unpublished) http://www.investkl.gov.my/Relevant_News-@-International_Invention,_Innovation_-%E2%97%98-_Technology_Exhibition_(ITEX_2018)%EF%BB%BF.aspx
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Abdul Rahman, Rozlin Sha'ban, Munirah Zulkifly, Ahmad Hafiz Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product
description	Articular cartilage has poor repair capacity due to its avascular and aneural properties. To date, there is no definitive treatment that can delay or reverse the degenerative process in cartilage. Therefore this bioartificial articular cartilage substitute is one of the alternatives that employ essential tissue engineering triad, which consist of i) quality cell source i.e. autologous bone marrow mesenchymal stem cells (BMSCs), ii) biomaterial scaffolds i.e. synthetic poly(lactic-co-glycolic)acid (PLGA) [+] natural fibrin and iii) signalling factors (chemical and/or physical stimuli) i.e. selected growth medium. All threecomponents are combined together forming PLGA-based scaffolds and BMSCs to restore damaged joint cartilage. Our implant model demonstrated promising findings with satisfactory structural and functional cartilaginous tissue restoration based on the International Cartilage Repair Society (ICRS) classification and the modified O’Driscoll histological grading scale. This reliable autologous matrix-induced cartilage implantation system uses one’s own cells, therefore the approach can be used to bypass certain social and scientific issues surrounding the conventional tissue or organ transplantation.
format	Conference or Workshop Item
author	Abdul Rahman, Rozlin Sha'ban, Munirah Zulkifly, Ahmad Hafiz
author_facet	Abdul Rahman, Rozlin Sha'ban, Munirah Zulkifly, Ahmad Hafiz
author_sort	Abdul Rahman, Rozlin
title	Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product
title_short	Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product
title_full	Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product
title_fullStr	Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product
title_full_unstemmed	Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product
title_sort	bioartificial articular cartilage substitute (bacs): advancing functional tissue engineered medical product
publishDate	2018
url	http://irep.iium.edu.my/64956/ http://irep.iium.edu.my/64956/ http://irep.iium.edu.my/64956/1/ITEX18_POSTER.pdf http://irep.iium.edu.my/64956/7/IMG_20180806_0001.pdf
first_indexed	2023-09-18T21:32:11Z
last_indexed	2023-09-18T21:32:11Z
_version_	1777412584177139712

Bioartificial Articular Cartilage Substitute (BACS): advancing functional tissue engineered medical product

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