In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds

We have aimed to evaluate the in vitro cytotoxic and in vivo anxiolytic and sedative activities of the methanolic extract of Sterculia villosa roxb seeds. The dried powder of the seeds was extracted with methanol which was then tested to ascertain the neuropharmacological and cytotoxic potential...

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Main Authors:	Barua, Soumitra, Banna, Hasanul, Hasan, Md Mahmudul, Azam, Shofiul, Jainul, Mohammed Abdullah, Azad, Abul Kalam, Helaluddin, Abul Bashar Mohammed
Format:	Article
Language:	English English
Published:	SILAE (Italo-Latin American Society of Ethnomedicine) 2018
Subjects:	QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/64947/ http://irep.iium.edu.my/64947/ http://irep.iium.edu.my/64947/1/64947_In%20vitro%20cytotoxic.pdf http://irep.iium.edu.my/64947/2/64947_In%20vitro%20cytotoxic_SCOPUS.pdf

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spelling	iium-649472018-08-03T04:22:43Z http://irep.iium.edu.my/64947/ In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds Barua, Soumitra Banna, Hasanul Hasan, Md Mahmudul Azam, Shofiul Jainul, Mohammed Abdullah Azad, Abul Kalam Helaluddin, Abul Bashar Mohammed QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry We have aimed to evaluate the in vitro cytotoxic and in vivo anxiolytic and sedative activities of the methanolic extract of Sterculia villosa roxb seeds. The dried powder of the seeds was extracted with methanol which was then tested to ascertain the neuropharmacological and cytotoxic potentials. The methanolic extract of Sterculia villosa roxb were subjected to Brine Shrimp lethality bioassay for possible cytotoxicity having LC 50 of 8.672μg/ml. However, fractions produced concentration dependent increase in percent of mortality of Brine Shrimp nauplii indicates the presence of cytotoxic property. We also have studied for possible sedative and anxiolytic activity of the methanolic seed extract of Sterculia villosa roxb in mice. This study includes hole cross, open field, thiopental- sodium induced sleeping time and elevated-plus maze (EPM) tests at the dose of 200 mg/kg while on the peripheral and central nervous system the extract mild to moderately decreased the locomotor activity of mice in hole cross, open field and EPM test. However, the extract moderately has minimized the onset of sleep and slightly has maximized the duration of sleep while administered with thiopental sodium. SILAE (Italo-Latin American Society of Ethnomedicine) 2018-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64947/1/64947_In%20vitro%20cytotoxic.pdf application/pdf en http://irep.iium.edu.my/64947/2/64947_In%20vitro%20cytotoxic_SCOPUS.pdf Barua, Soumitra and Banna, Hasanul and Hasan, Md Mahmudul and Azam, Shofiul and Jainul, Mohammed Abdullah and Azad, Abul Kalam and Helaluddin, Abul Bashar Mohammed (2018) In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds. PharmacologyOnline, Archive 2018 (1). pp. 137-142. ISSN 1827-8620 http://pharmacologyonline.silae.it/files/archives/2018/vol1/PhOL_2018_1_A015_Barua.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Barua, Soumitra Banna, Hasanul Hasan, Md Mahmudul Azam, Shofiul Jainul, Mohammed Abdullah Azad, Abul Kalam Helaluddin, Abul Bashar Mohammed In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds
description	We have aimed to evaluate the in vitro cytotoxic and in vivo anxiolytic and sedative activities of the methanolic extract of Sterculia villosa roxb seeds. The dried powder of the seeds was extracted with methanol which was then tested to ascertain the neuropharmacological and cytotoxic potentials. The methanolic extract of Sterculia villosa roxb were subjected to Brine Shrimp lethality bioassay for possible cytotoxicity having LC 50 of 8.672μg/ml. However, fractions produced concentration dependent increase in percent of mortality of Brine Shrimp nauplii indicates the presence of cytotoxic property. We also have studied for possible sedative and anxiolytic activity of the methanolic seed extract of Sterculia villosa roxb in mice. This study includes hole cross, open field, thiopental- sodium induced sleeping time and elevated-plus maze (EPM) tests at the dose of 200 mg/kg while on the peripheral and central nervous system the extract mild to moderately decreased the locomotor activity of mice in hole cross, open field and EPM test. However, the extract moderately has minimized the onset of sleep and slightly has maximized the duration of sleep while administered with thiopental sodium.
format	Article
author	Barua, Soumitra Banna, Hasanul Hasan, Md Mahmudul Azam, Shofiul Jainul, Mohammed Abdullah Azad, Abul Kalam Helaluddin, Abul Bashar Mohammed
author_facet	Barua, Soumitra Banna, Hasanul Hasan, Md Mahmudul Azam, Shofiul Jainul, Mohammed Abdullah Azad, Abul Kalam Helaluddin, Abul Bashar Mohammed
author_sort	Barua, Soumitra
title	In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds
title_short	In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds
title_full	In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds
title_fullStr	In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds
title_full_unstemmed	In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds
title_sort	in vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of streculia villosa seeds
publisher	SILAE (Italo-Latin American Society of Ethnomedicine)
publishDate	2018
url	http://irep.iium.edu.my/64947/ http://irep.iium.edu.my/64947/ http://irep.iium.edu.my/64947/1/64947_In%20vitro%20cytotoxic.pdf http://irep.iium.edu.my/64947/2/64947_In%20vitro%20cytotoxic_SCOPUS.pdf
first_indexed	2023-09-18T21:32:10Z
last_indexed	2023-09-18T21:32:10Z
_version_	1777412583489273856

In vitro cytotoxic and in vivo anxiolytic study of methanolic crude extract of Streculia villosa seeds

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