The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management

Anacardium occidentale Linn. (A. occidentale L.) commonly known as cashew tree, is a popular tropical plant among local people and has been known to possess an excellent source of bioactive compounds. Bioactive compounds of A. occidentale L. have potency as antidiabetic for type 2 diabetes mellitus...

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Main Authors:	Abdullah Thaidi, Nur Imanina, Haron, Normah, Darnis, Deny Susanti, Mat Jusoh, Hanapi
Format:	Conference or Workshop Item
Language:	English English
Published:	2018
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/64789/ http://irep.iium.edu.my/64789/ http://irep.iium.edu.my/64789/1/64789_THE%20ROLE%20OF%20BIOACTIVE%20COMPOUNDS-%20ABSTRACT.pdf http://irep.iium.edu.my/64789/2/64789_THE%20ROLE%20OF%20BIOACTIVE%20COMPOUNDS-%20SLIDE.pdf

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recordtype	eprints
spelling	iium-647892018-07-27T02:06:54Z http://irep.iium.edu.my/64789/ The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management Abdullah Thaidi, Nur Imanina Haron, Normah Darnis, Deny Susanti Mat Jusoh, Hanapi QD Chemistry Anacardium occidentale Linn. (A. occidentale L.) commonly known as cashew tree, is a popular tropical plant among local people and has been known to possess an excellent source of bioactive compounds. Bioactive compounds of A. occidentale L. have potency as antidiabetic for type 2 diabetes mellitus (T2DM) management. Some strategies for T2DM management are by maintaining the postprandial glucose level through the inhibition of α-amylase and by preventing the hydrolysis of Glucagon Like Peptide-1 (GLP-1) through the inhibition of Dipeptidyl peptidase IV (DPP-IV). The present study was aimed to investigate the role of bioactive compounds from A. occidentale L. in inhibiting the DPP-IV and α-amylase. HPLC-UV-Vis is used to identify and quantify the phenolic compounds present by comparing with external standards, namely, ferulic acid, p-coumaric acid, gallic acid, kaempferol and quercetin. Three fractions of maceration extracts (shoots and leaves) using methanol as solvent were undergone inhibition analysis by α-amylase assay and DPP-IV Glo protease assay. α-Amylase inhibitory activity was measured using spectrophotometric method at λ = 540 nm with acarbose as positive control. DPP-IV inhibitory activity was measured using luminescent with kaempferol as positive control. All the extracts from shoots and leaves tested revealed there were potent α-amylase and DPP-IV inhibitors, contributing to the inhibition activity significantly. Therefore, A. occidentale L. extracts could serve as a potential source to manage T2DM. 2018-03-19 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/64789/1/64789_THE%20ROLE%20OF%20BIOACTIVE%20COMPOUNDS-%20ABSTRACT.pdf application/pdf en http://irep.iium.edu.my/64789/2/64789_THE%20ROLE%20OF%20BIOACTIVE%20COMPOUNDS-%20SLIDE.pdf Abdullah Thaidi, Nur Imanina and Haron, Normah and Darnis, Deny Susanti and Mat Jusoh, Hanapi (2018) The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management. In: 34th International Conference on Natural Products (ICNP 2018), 19th-21st March 2018, Bayview Beach Resort, Pulau Pinang. (Unpublished) http://www.icnp2018.usm.my/images/ICNP/E-Abstract/ICNP-2018-E-Book.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Abdullah Thaidi, Nur Imanina Haron, Normah Darnis, Deny Susanti Mat Jusoh, Hanapi The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management
description	Anacardium occidentale Linn. (A. occidentale L.) commonly known as cashew tree, is a popular tropical plant among local people and has been known to possess an excellent source of bioactive compounds. Bioactive compounds of A. occidentale L. have potency as antidiabetic for type 2 diabetes mellitus (T2DM) management. Some strategies for T2DM management are by maintaining the postprandial glucose level through the inhibition of α-amylase and by preventing the hydrolysis of Glucagon Like Peptide-1 (GLP-1) through the inhibition of Dipeptidyl peptidase IV (DPP-IV). The present study was aimed to investigate the role of bioactive compounds from A. occidentale L. in inhibiting the DPP-IV and α-amylase. HPLC-UV-Vis is used to identify and quantify the phenolic compounds present by comparing with external standards, namely, ferulic acid, p-coumaric acid, gallic acid, kaempferol and quercetin. Three fractions of maceration extracts (shoots and leaves) using methanol as solvent were undergone inhibition analysis by α-amylase assay and DPP-IV Glo protease assay. α-Amylase inhibitory activity was measured using spectrophotometric method at λ = 540 nm with acarbose as positive control. DPP-IV inhibitory activity was measured using luminescent with kaempferol as positive control. All the extracts from shoots and leaves tested revealed there were potent α-amylase and DPP-IV inhibitors, contributing to the inhibition activity significantly. Therefore, A. occidentale L. extracts could serve as a potential source to manage T2DM.
format	Conference or Workshop Item
author	Abdullah Thaidi, Nur Imanina Haron, Normah Darnis, Deny Susanti Mat Jusoh, Hanapi
author_facet	Abdullah Thaidi, Nur Imanina Haron, Normah Darnis, Deny Susanti Mat Jusoh, Hanapi
author_sort	Abdullah Thaidi, Nur Imanina
title	The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management
title_short	The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management
title_full	The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management
title_fullStr	The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management
title_full_unstemmed	The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management
title_sort	role of bioactive compounds from anacardium occidentale linn. on alpha amylase and dipeptidyl peptidase iv as antidiabetic agent for type 2 diabetes mellitus management
publishDate	2018
url	http://irep.iium.edu.my/64789/ http://irep.iium.edu.my/64789/ http://irep.iium.edu.my/64789/1/64789_THE%20ROLE%20OF%20BIOACTIVE%20COMPOUNDS-%20ABSTRACT.pdf http://irep.iium.edu.my/64789/2/64789_THE%20ROLE%20OF%20BIOACTIVE%20COMPOUNDS-%20SLIDE.pdf
first_indexed	2023-09-18T21:31:57Z
last_indexed	2023-09-18T21:31:57Z
_version_	1777412569889243136

The role of bioactive compounds from Anacardium Occidentale Linn. On alpha amylase and dipeptidyl peptidase IV as antidiabetic agent for type 2 diabetes mellitus management

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