Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes

Ultrasound is extensively used in various clinical specialities since it was perceived to lack in bioeffects. In obstetrics and gynaecology, it has been proven useful in fetal assessment and abnormalities. Due to high sensitivity of developing fetus to external interferences, through diagnostic ultr...

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Main Authors:	Md Dom, Sulaiman, Ahmad Zaiki, Farah Wahida
Format:	Book
Language:	English
Published:	LAP LAMBERT Academic Publishing 2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/64712/ http://irep.iium.edu.my/64712/ http://irep.iium.edu.my/64712/1/64712_Effects%20of%20Prenatal%20Diagnostic.pdf

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recordtype	eprints
spelling	iium-647122019-01-08T02:29:28Z http://irep.iium.edu.my/64712/ Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes Md Dom, Sulaiman Ahmad Zaiki, Farah Wahida R Medicine (General) Ultrasound is extensively used in various clinical specialities since it was perceived to lack in bioeffects. In obstetrics and gynaecology, it has been proven useful in fetal assessment and abnormalities. Due to high sensitivity of developing fetus to external interferences, through diagnostic ultrasound advances, the revision of potential prenatal bioeffects is needed to be corroborated. This in-vivo experimental study was designed to determine the physical and morphological effects on fetus development. Twelve pregnant rabbits were exposed to ultrasound exposure durations of 30, 60 and 90 minutes in the middle of three stipulated gestational stages. All other acoustic output parameters were kept constant throughout the study. Total 136 foetuses; group O: n=31, A: n=35, B: n=31, and C: n=39 were analysed. One-way ANOVA showed significant differences in foetal weight at the 1st stage and 3rd stage exposed for 90 minutes (P=0.01 and 0.05 respectively), and at the 2nd stage exposed for 60 minutes (P=0.01). Pearson correlation showed negative correlations between exposure durations and foetal weight at the 1st and 3rd stage (P=0.02 and 0.04 respectively), while Simple Linear Regression showed significant linear relationship. For brain volume and surface, significant differences found in brain volume and surface at the 2nd stage exposed for 60 and 90 minutes, and at the 3rd stage exposed for 60 minutes. No significant linear relationship found between exposure durations and brain volume and surface at all stages. Result suggested that prenatal ultrasound exposure might interfere with those sensitive stages hence, plausibly interrupted the physical development. Further work is needed to provide more scientific evidences on prenatal ultrasound effects on foetus. LAP LAMBERT Academic Publishing 2018 Book PeerReviewed application/pdf en http://irep.iium.edu.my/64712/1/64712_Effects%20of%20Prenatal%20Diagnostic.pdf Md Dom, Sulaiman and Ahmad Zaiki, Farah Wahida (2018) Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes. LAP LAMBERT Academic Publishing, Berlin. ISBN 978-613-8-23011-3 https://www.lap-publishing.com/catalog/details//store/gb/book/978-613-8-23011-3/effects-of-prenatal-diagnostic-ultrasound-exposure-on-rabbit-fetus?locale=tr
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Md Dom, Sulaiman Ahmad Zaiki, Farah Wahida Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes
description	Ultrasound is extensively used in various clinical specialities since it was perceived to lack in bioeffects. In obstetrics and gynaecology, it has been proven useful in fetal assessment and abnormalities. Due to high sensitivity of developing fetus to external interferences, through diagnostic ultrasound advances, the revision of potential prenatal bioeffects is needed to be corroborated. This in-vivo experimental study was designed to determine the physical and morphological effects on fetus development. Twelve pregnant rabbits were exposed to ultrasound exposure durations of 30, 60 and 90 minutes in the middle of three stipulated gestational stages. All other acoustic output parameters were kept constant throughout the study. Total 136 foetuses; group O: n=31, A: n=35, B: n=31, and C: n=39 were analysed. One-way ANOVA showed significant differences in foetal weight at the 1st stage and 3rd stage exposed for 90 minutes (P=0.01 and 0.05 respectively), and at the 2nd stage exposed for 60 minutes (P=0.01). Pearson correlation showed negative correlations between exposure durations and foetal weight at the 1st and 3rd stage (P=0.02 and 0.04 respectively), while Simple Linear Regression showed significant linear relationship. For brain volume and surface, significant differences found in brain volume and surface at the 2nd stage exposed for 60 and 90 minutes, and at the 3rd stage exposed for 60 minutes. No significant linear relationship found between exposure durations and brain volume and surface at all stages. Result suggested that prenatal ultrasound exposure might interfere with those sensitive stages hence, plausibly interrupted the physical development. Further work is needed to provide more scientific evidences on prenatal ultrasound effects on foetus.
format	Book
author	Md Dom, Sulaiman Ahmad Zaiki, Farah Wahida
author_facet	Md Dom, Sulaiman Ahmad Zaiki, Farah Wahida
author_sort	Md Dom, Sulaiman
title	Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes
title_short	Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes
title_full	Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes
title_fullStr	Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes
title_full_unstemmed	Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes
title_sort	effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes
publisher	LAP LAMBERT Academic Publishing
publishDate	2018
url	http://irep.iium.edu.my/64712/ http://irep.iium.edu.my/64712/ http://irep.iium.edu.my/64712/1/64712_Effects%20of%20Prenatal%20Diagnostic.pdf
first_indexed	2023-09-18T21:31:50Z
last_indexed	2023-09-18T21:31:50Z
_version_	1777412562089934848

Effects of prenatal diagnostic ultrasound exposure on rabbit fetus: in vivo physical and morphological changes

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