Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential

The development of the alpha-glucosidase inhibitor provides a new approach in the management of diabetes. α-Glucosidase enzyme belongs to the glycosidase family enzymes, cleave the glycosidic bond of the oligosaccharides that liberate glucose and its inhibition retards the carbohydrate digestion. I...

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Main Authors:	Rahman, Md. Mokhlesur, Raja Hussin, Tengku Mohammad Ariff, Abdul Latif, Ahmad Zubaidi, Md Aris, Mohd Aznan, Awang, Mohamed, Mat So'ad, Siti Zaiton, Sanaullah Khan, Rao, Hilmi, Nur Nadhirah, Wan Nik, Wan Norsani
Format:	Conference or Workshop Item
Language:	English English
Published:	2018
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/64649/ http://irep.iium.edu.my/64649/1/unisza%20award.jpg http://irep.iium.edu.my/64649/6/MPI%202018-%20posterirep.pdf

id	iium-64649
recordtype	eprints
spelling	iium-646492018-07-26T06:36:23Z http://irep.iium.edu.my/64649/ Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential Rahman, Md. Mokhlesur Raja Hussin, Tengku Mohammad Ariff Abdul Latif, Ahmad Zubaidi Md Aris, Mohd Aznan Awang, Mohamed Mat So'ad, Siti Zaiton Sanaullah Khan, Rao Hilmi, Nur Nadhirah Wan Nik, Wan Norsani QD Chemistry The development of the alpha-glucosidase inhibitor provides a new approach in the management of diabetes. α-Glucosidase enzyme belongs to the glycosidase family enzymes, cleave the glycosidic bond of the oligosaccharides that liberate glucose and its inhibition retards the carbohydrate digestion. In the present study, interest is focused on experimental researches conducted on hypoglycemic fruit particularly those which show alpha glucosidase inhibitor activity alongside bioactive components. We will studied the structural features of different of a small molecules (α-glucosidase) inhibitors are responsible for the inhibitory activities. The reported computational studies pharmacophore modelling and docking (with analogs enzymes), revealed that the topological, electronic and hydrophobicity properties determine the interactions of those molecules. The aromatic substituents connected with flexible bonds in the molecules have significant effect on the interactions, which may due to the presence of aromatic amino acid residues in the active site. Multiple sequence alignments of the α-glucosidase enzymes described that the amino acid residues are present in the active site of all the studied enzymes. This research will be concluded that this α-glucosidase inhibitor obtain from natural product (Flesh of Salacca Zalacca Fruit) used Super Critical Flud Extraction (SFE) Method are used for the treatment of diabetic type 2. The structural analysis of these synthesized and natural derivatives guide for the development of novel α-glucosidase inhibitors with free of toxicities. An efficient and selective method is needed to be established to harvest only the desirable aroma compounds and α–Glucosidase Inhibitor from the flesh of Salak fruit. 2018-04-07 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/64649/1/unisza%20award.jpg application/pdf en http://irep.iium.edu.my/64649/6/MPI%202018-%20posterirep.pdf Rahman, Md. Mokhlesur and Raja Hussin, Tengku Mohammad Ariff and Abdul Latif, Ahmad Zubaidi and Md Aris, Mohd Aznan and Awang, Mohamed and Mat So'ad, Siti Zaiton and Sanaullah Khan, Rao and Hilmi, Nur Nadhirah and Wan Nik, Wan Norsani (2018) Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential. In: Minggu Penyelidikan dan Inovasi 2018, 7th-9th April 2018, Kuala Terengganu, Terengganu. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Rahman, Md. Mokhlesur Raja Hussin, Tengku Mohammad Ariff Abdul Latif, Ahmad Zubaidi Md Aris, Mohd Aznan Awang, Mohamed Mat So'ad, Siti Zaiton Sanaullah Khan, Rao Hilmi, Nur Nadhirah Wan Nik, Wan Norsani Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential
description	The development of the alpha-glucosidase inhibitor provides a new approach in the management of diabetes. α-Glucosidase enzyme belongs to the glycosidase family enzymes, cleave the glycosidic bond of the oligosaccharides that liberate glucose and its inhibition retards the carbohydrate digestion. In the present study, interest is focused on experimental researches conducted on hypoglycemic fruit particularly those which show alpha glucosidase inhibitor activity alongside bioactive components. We will studied the structural features of different of a small molecules (α-glucosidase) inhibitors are responsible for the inhibitory activities. The reported computational studies pharmacophore modelling and docking (with analogs enzymes), revealed that the topological, electronic and hydrophobicity properties determine the interactions of those molecules. The aromatic substituents connected with flexible bonds in the molecules have significant effect on the interactions, which may due to the presence of aromatic amino acid residues in the active site. Multiple sequence alignments of the α-glucosidase enzymes described that the amino acid residues are present in the active site of all the studied enzymes. This research will be concluded that this α-glucosidase inhibitor obtain from natural product (Flesh of Salacca Zalacca Fruit) used Super Critical Flud Extraction (SFE) Method are used for the treatment of diabetic type 2. The structural analysis of these synthesized and natural derivatives guide for the development of novel α-glucosidase inhibitors with free of toxicities. An efficient and selective method is needed to be established to harvest only the desirable aroma compounds and α–Glucosidase Inhibitor from the flesh of Salak fruit.
format	Conference or Workshop Item
author	Rahman, Md. Mokhlesur Raja Hussin, Tengku Mohammad Ariff Abdul Latif, Ahmad Zubaidi Md Aris, Mohd Aznan Awang, Mohamed Mat So'ad, Siti Zaiton Sanaullah Khan, Rao Hilmi, Nur Nadhirah Wan Nik, Wan Norsani
author_facet	Rahman, Md. Mokhlesur Raja Hussin, Tengku Mohammad Ariff Abdul Latif, Ahmad Zubaidi Md Aris, Mohd Aznan Awang, Mohamed Mat So'ad, Siti Zaiton Sanaullah Khan, Rao Hilmi, Nur Nadhirah Wan Nik, Wan Norsani
author_sort	Rahman, Md. Mokhlesur
title	Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential
title_short	Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential
title_full	Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential
title_fullStr	Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential
title_full_unstemmed	Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential
title_sort	bioactive compounds and aroma from the flesh of salak(salacca zalacca) fruit and antidiabetic potential
publishDate	2018
url	http://irep.iium.edu.my/64649/ http://irep.iium.edu.my/64649/1/unisza%20award.jpg http://irep.iium.edu.my/64649/6/MPI%202018-%20posterirep.pdf
first_indexed	2023-09-18T21:31:45Z
last_indexed	2023-09-18T21:31:45Z
_version_	1777412556876414976

Bioactive compounds and aroma from the flesh of salak(Salacca zalacca) fruit and antidiabetic potential

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