Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice

Direct oral anticoagulants (DOACs), such as dabigatran and rivaroxaban, have in the past decade replaced vitamin k antagonists (VKAs), such as warfarin, as standard treatment for thrombosis prophylaxis and stroke prevention in patients with atrial fibrillation (AF). Adherence to DOACs is crucial to...

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Main Authors:	Kubas, Mohammed Abdullah, Zin, Che Suraya, Shabaruddin, Fatiha Hana
Format:	Conference or Workshop Item
Language:	English
Published:	2018
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/64557/ http://irep.iium.edu.my/64557/ http://irep.iium.edu.my/64557/1/64557_Systematic%20review%20of%20adherence%20to%20direct%20oral.pdf

id	iium-64557
recordtype	eprints
spelling	iium-645572018-07-20T08:14:34Z http://irep.iium.edu.my/64557/ Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice Kubas, Mohammed Abdullah Zin, Che Suraya Shabaruddin, Fatiha Hana RS Pharmacy and materia medica Direct oral anticoagulants (DOACs), such as dabigatran and rivaroxaban, have in the past decade replaced vitamin k antagonists (VKAs), such as warfarin, as standard treatment for thrombosis prophylaxis and stroke prevention in patients with atrial fibrillation (AF). Adherence to DOACs is crucial to optimise clinical outcomes in patients with AF. The aim of this review is to systematically evaluate published evidence describing adherence to DOACs in patients with AF in real world clinical practice. A systematic search combining terms for direct oral anticoagulants, atrial fibrilation and relevant adherence measurement tools was conducted in PubMed in March 2018 to identify related English language publications. All observational cohort studies that assessed adherence of DOACs in patients with AF by using healthcare institution databases, including pharmacy records, medical claims datasets, and other relevant data were reviewed for inclusion. Data describing study characteristics and adherence profile were extracted and summarised using qualitative methods. The PubMed search identified 278 citations. After screening the titles and abstracts, full articles were obtained for 36 articles and of these, 22 articles were included. These 22 studies involved around 300,000 AF patients, described the adherence of DOACs in clinical practice in the United States, Europe, and Turkey and were published between 2013 to 2018. Proportion of days covered (PDC) was the most commonly used tool for adherence measurement followed by medicine possession ratio (MPR). Adherence to DOACs was found to be good in most studies, defined as PDC ≥80% and MPR ≥80%. While these published evidence indicated that adherence to DOACs in real world clinical practice is generally good, clinical outcomes can be optimised by identifying AF patients with sub-optimal adherence and developing interventions to improve adherence in these patients within clinical practice. 2018-06-27 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/64557/1/64557_Systematic%20review%20of%20adherence%20to%20direct%20oral.pdf Kubas, Mohammed Abdullah and Zin, Che Suraya and Shabaruddin, Fatiha Hana (2018) Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice. In: 1st International Conference on Pharmacy Practice 2018, 27th-28th June 2018, Shah Alam, Selangor. (Unpublished) http://icopp.uitm.edu.my/ICOPP%20Abstract%20Book.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Kubas, Mohammed Abdullah Zin, Che Suraya Shabaruddin, Fatiha Hana Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice
description	Direct oral anticoagulants (DOACs), such as dabigatran and rivaroxaban, have in the past decade replaced vitamin k antagonists (VKAs), such as warfarin, as standard treatment for thrombosis prophylaxis and stroke prevention in patients with atrial fibrillation (AF). Adherence to DOACs is crucial to optimise clinical outcomes in patients with AF. The aim of this review is to systematically evaluate published evidence describing adherence to DOACs in patients with AF in real world clinical practice. A systematic search combining terms for direct oral anticoagulants, atrial fibrilation and relevant adherence measurement tools was conducted in PubMed in March 2018 to identify related English language publications. All observational cohort studies that assessed adherence of DOACs in patients with AF by using healthcare institution databases, including pharmacy records, medical claims datasets, and other relevant data were reviewed for inclusion. Data describing study characteristics and adherence profile were extracted and summarised using qualitative methods. The PubMed search identified 278 citations. After screening the titles and abstracts, full articles were obtained for 36 articles and of these, 22 articles were included. These 22 studies involved around 300,000 AF patients, described the adherence of DOACs in clinical practice in the United States, Europe, and Turkey and were published between 2013 to 2018. Proportion of days covered (PDC) was the most commonly used tool for adherence measurement followed by medicine possession ratio (MPR). Adherence to DOACs was found to be good in most studies, defined as PDC ≥80% and MPR ≥80%. While these published evidence indicated that adherence to DOACs in real world clinical practice is generally good, clinical outcomes can be optimised by identifying AF patients with sub-optimal adherence and developing interventions to improve adherence in these patients within clinical practice.
format	Conference or Workshop Item
author	Kubas, Mohammed Abdullah Zin, Che Suraya Shabaruddin, Fatiha Hana
author_facet	Kubas, Mohammed Abdullah Zin, Che Suraya Shabaruddin, Fatiha Hana
author_sort	Kubas, Mohammed Abdullah
title	Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice
title_short	Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice
title_full	Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice
title_fullStr	Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice
title_full_unstemmed	Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice
title_sort	systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice
publishDate	2018
url	http://irep.iium.edu.my/64557/ http://irep.iium.edu.my/64557/ http://irep.iium.edu.my/64557/1/64557_Systematic%20review%20of%20adherence%20to%20direct%20oral.pdf
first_indexed	2023-09-18T21:31:37Z
last_indexed	2023-09-18T21:31:37Z
_version_	1777412549339250688

Systematic review of adherence to direct oral anticoagulants in patients with atrial fibrilation in clinical practice

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