Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review

Introduction: Candida organisms are opportunistic fungal pathogens that have become a major cause of nosocomial infections worldwide. We investigated the clinical characteristics and outcomes of hospitalized patients with candidaemia caused by Candida albicans and non-albicans Candida spp at HUSM....

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Main Author:	Ali Tajuddin, Amalina Haydar
Format:	Article
Language:	English English English
Published:	International Islamic University Malaysia (IIUM) 2018
Subjects:	RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
Online Access:	http://irep.iium.edu.my/64405/ http://irep.iium.edu.my/64405/ http://irep.iium.edu.my/64405/1/64405_Epidemiology%20and%20Outcomes%20of%20Candidaemia%20among_article.pdf http://irep.iium.edu.my/64405/2/64405_Epidemiology%20and%20Outcomes%20of%20Candidaemia%20among_scopus.pdf http://irep.iium.edu.my/64405/13/64405_Epidemiology%20and%20outcomes%20of%20candidaemia%20among_WoS.pdf

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spelling	iium-644052018-10-18T01:46:02Z http://irep.iium.edu.my/64405/ Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review Ali Tajuddin, Amalina Haydar RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology Introduction: Candida organisms are opportunistic fungal pathogens that have become a major cause of nosocomial infections worldwide. We investigated the clinical characteristics and outcomes of hospitalized patients with candidaemia caused by Candida albicans and non-albicans Candida spp at HUSM. Materials and Methods: We retrospectively evaluated all hospitalized patients with candidaemia from January 2010 till December 2014 based on inpatient hospital records and laboratory data. Results: A total of 134 patients with candidaemia were enrolled. Candida albicans and non-albicans Candida spp were responsible for 20% (27/134) and 80% (107/134) of candidaemia cases, respectively. Hospitalized patients with diabetes mellitus, surgical conditions, or concomitant septicaemia and those who received instrumentations such as CVC or CBD, and those admitted under medical settings were prone to develop candidaemia caused by either C. albicans or non-albicans Candida spp. All isolates were susceptible to Fluconazole except for C. krusei isolates. All-cause mortality within 30 days post diagnosis of candidaemia was 59%. Factors associated with mortality were solid tumor (p =0.014), surgical illness (p=0.128), central venous catheterization (p= 0.096) and leucocytosis (p=0.116). Only solid tumor was an independent contributory factor for mortality among patients with C. albicans candidaemia in the multivariate analyses (OR 5.09, 95% CI 1.38,18.74, p=0.014). Conclusions: The patients’ clinical characteristics were fairly comparable between Candida albicans and non-albicans candidaemia. The changing epidemiology of candidaemia at this centre was in fact alarming. The outcome associated with candidaemia was poor. International Islamic University Malaysia (IIUM) 2018-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64405/1/64405_Epidemiology%20and%20Outcomes%20of%20Candidaemia%20among_article.pdf application/pdf en http://irep.iium.edu.my/64405/2/64405_Epidemiology%20and%20Outcomes%20of%20Candidaemia%20among_scopus.pdf application/pdf en http://irep.iium.edu.my/64405/13/64405_Epidemiology%20and%20outcomes%20of%20candidaemia%20among_WoS.pdf Ali Tajuddin, Amalina Haydar (2018) Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review. International Medical Journal Malaysia, 17 (1). pp. 3-12. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_17_no_1/Vol17-No1-p003012.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology
spellingShingle	RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology Ali Tajuddin, Amalina Haydar Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review
description	Introduction: Candida organisms are opportunistic fungal pathogens that have become a major cause of nosocomial infections worldwide. We investigated the clinical characteristics and outcomes of hospitalized patients with candidaemia caused by Candida albicans and non-albicans Candida spp at HUSM. Materials and Methods: We retrospectively evaluated all hospitalized patients with candidaemia from January 2010 till December 2014 based on inpatient hospital records and laboratory data. Results: A total of 134 patients with candidaemia were enrolled. Candida albicans and non-albicans Candida spp were responsible for 20% (27/134) and 80% (107/134) of candidaemia cases, respectively. Hospitalized patients with diabetes mellitus, surgical conditions, or concomitant septicaemia and those who received instrumentations such as CVC or CBD, and those admitted under medical settings were prone to develop candidaemia caused by either C. albicans or non-albicans Candida spp. All isolates were susceptible to Fluconazole except for C. krusei isolates. All-cause mortality within 30 days post diagnosis of candidaemia was 59%. Factors associated with mortality were solid tumor (p =0.014), surgical illness (p=0.128), central venous catheterization (p= 0.096) and leucocytosis (p=0.116). Only solid tumor was an independent contributory factor for mortality among patients with C. albicans candidaemia in the multivariate analyses (OR 5.09, 95% CI 1.38,18.74, p=0.014). Conclusions: The patients’ clinical characteristics were fairly comparable between Candida albicans and non-albicans candidaemia. The changing epidemiology of candidaemia at this centre was in fact alarming. The outcome associated with candidaemia was poor.
format	Article
author	Ali Tajuddin, Amalina Haydar
author_facet	Ali Tajuddin, Amalina Haydar
author_sort	Ali Tajuddin, Amalina Haydar
title	Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review
title_short	Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review
title_full	Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review
title_fullStr	Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review
title_full_unstemmed	Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review
title_sort	epidemiology and outcomes of candidaemia among adult patients admitted at hospital universiti sains malaysia (husm): a 5-year review
publisher	International Islamic University Malaysia (IIUM)
publishDate	2018
url	http://irep.iium.edu.my/64405/ http://irep.iium.edu.my/64405/ http://irep.iium.edu.my/64405/1/64405_Epidemiology%20and%20Outcomes%20of%20Candidaemia%20among_article.pdf http://irep.iium.edu.my/64405/2/64405_Epidemiology%20and%20Outcomes%20of%20Candidaemia%20among_scopus.pdf http://irep.iium.edu.my/64405/13/64405_Epidemiology%20and%20outcomes%20of%20candidaemia%20among_WoS.pdf
first_indexed	2023-09-18T21:31:26Z
last_indexed	2023-09-18T21:31:26Z
_version_	1777412536995414016

Epidemiology and outcomes of candidaemia among adult patients admitted at Hospital Universiti Sains Malaysia (HUSM): A 5-year review

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