Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square

Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscop...

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Main Authors:	Saleh, Mohammed S M, Siddiqui, Mohammad Jamshed Ahmad, Mat So'ad, Siti Zaiton, Roheem, Fatimah, Bes-Bes, Salima Saidi, Khatib, Alfi
Format:	Article
Language:	English English English
Published:	MDPI 2018
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/64259/ http://irep.iium.edu.my/64259/ http://irep.iium.edu.my/64259/ http://irep.iium.edu.my/64259/7/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20Salak%20%28Salacca%20zalacca%29_article.pdf http://irep.iium.edu.my/64259/13/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak%20%28salacca%20zalacca%29%20fruit%20extracts%20utilizing%20orthogonal%20partial%20least%20square_WOS.pdf http://irep.iium.edu.my/64259/18/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak_SCOPUS.pdf

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spelling	iium-642592019-01-24T02:28:08Z http://irep.iium.edu.my/64259/ Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mat So'ad, Siti Zaiton Roheem, Fatimah Bes-Bes, Salima Saidi Khatib, Alfi QD Chemistry Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscopy (FT-IR) fingerprint, utilizing orthogonal partial least square. This calibration model was applied to develop a rapid analytical method tool for quality control of this fruit. A total of 36 extracts prepared with different solvent ratios of ethanol–water (100, 80, 60, 40.20, 0% v/v) and their α-glucosidase inhibitory activities determined. The FT-IR spectra of ethanol–water extracts measured in the region of 400 and 4000 cm−1 at a resolution of 4 cm−1. Multivariate analysis with a combination of orthogonal partial least-squares (OPLS) algorithm was used to correlate the bioactivity of the samples with the FT-IR spectral data. The OPLS biplot model identified several functional groups (C–H, C=O, C–N, N–H, C–O, and C=C) which actively induced α-glucosidase inhibitory activity. MDPI 2018-06-13 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64259/7/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20Salak%20%28Salacca%20zalacca%29_article.pdf application/pdf en http://irep.iium.edu.my/64259/13/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak%20%28salacca%20zalacca%29%20fruit%20extracts%20utilizing%20orthogonal%20partial%20least%20square_WOS.pdf application/pdf en http://irep.iium.edu.my/64259/18/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak_SCOPUS.pdf Saleh, Mohammed S M and Siddiqui, Mohammad Jamshed Ahmad and Mat So'ad, Siti Zaiton and Roheem, Fatimah and Bes-Bes, Salima Saidi and Khatib, Alfi (2018) Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square. Molecules, 23 (6). pp. 1-10. ISSN 1420-3049 http://www.mdpi.com/1420-3049/23/6/1434/htm 10.3390/molecules23061434
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QD Chemistry
spellingShingle	QD Chemistry Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mat So'ad, Siti Zaiton Roheem, Fatimah Bes-Bes, Salima Saidi Khatib, Alfi Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
description	Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscopy (FT-IR) fingerprint, utilizing orthogonal partial least square. This calibration model was applied to develop a rapid analytical method tool for quality control of this fruit. A total of 36 extracts prepared with different solvent ratios of ethanol–water (100, 80, 60, 40.20, 0% v/v) and their α-glucosidase inhibitory activities determined. The FT-IR spectra of ethanol–water extracts measured in the region of 400 and 4000 cm−1 at a resolution of 4 cm−1. Multivariate analysis with a combination of orthogonal partial least-squares (OPLS) algorithm was used to correlate the bioactivity of the samples with the FT-IR spectral data. The OPLS biplot model identified several functional groups (C–H, C=O, C–N, N–H, C–O, and C=C) which actively induced α-glucosidase inhibitory activity.
format	Article
author	Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mat So'ad, Siti Zaiton Roheem, Fatimah Bes-Bes, Salima Saidi Khatib, Alfi
author_facet	Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mat So'ad, Siti Zaiton Roheem, Fatimah Bes-Bes, Salima Saidi Khatib, Alfi
author_sort	Saleh, Mohammed S M
title	Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_short	Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_full	Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_fullStr	Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_full_unstemmed	Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square
title_sort	correlation of ft-ir fingerprint and α-glucosidase inhibitory activity of salak (salacca zalacca) fruit extracts utilizing orthogonal partial least square
publisher	MDPI
publishDate	2018
url	http://irep.iium.edu.my/64259/ http://irep.iium.edu.my/64259/ http://irep.iium.edu.my/64259/ http://irep.iium.edu.my/64259/7/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20Salak%20%28Salacca%20zalacca%29_article.pdf http://irep.iium.edu.my/64259/13/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak%20%28salacca%20zalacca%29%20fruit%20extracts%20utilizing%20orthogonal%20partial%20least%20square_WOS.pdf http://irep.iium.edu.my/64259/18/64259_Correlation%20of%20FT-IR%20fingerprint%20and%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20salak_SCOPUS.pdf
first_indexed	2023-09-18T21:31:10Z
last_indexed	2023-09-18T21:31:10Z
_version_	1777412520740388864

Correlation of FT-IR fingerprint and α-glucosidase inhibitory activity of Salak (Salacca zalacca) fruit extracts utilizing orthogonal partial least square

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