Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit

Background and objective: Blood glucose variability is common in healthcare and it is not related or influ- enced by diabetes mellitus. To minimise the risk of high blood glucose in critically ill patients, Stochastic Targeted Blood Glucose Control Protocol is used in intensive care unit at hospital...

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Main Authors:	Jamaludin, Ummu Kulthum, Mohamad Suhaimi, Fatanah, Abdul Razak, Normy Norfiza, Md Ralib, Azrina, Mat Nor, Mohd Basri, Christopher, Pretty, Luqman, Humaidi
Format:	Article
Language:	English English English
Published:	Elsevier Ireland Ltd 2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/63937/ http://irep.iium.edu.my/63937/ http://irep.iium.edu.my/63937/ http://irep.iium.edu.my/63937/2/63937_Performance%20of%20Stochastic%20Targeted%20Blood.pdf http://irep.iium.edu.my/63937/1/63937_Performance%20of%20Stochastic%20Targeted%20_SCOPUS.pdf http://irep.iium.edu.my/63937/13/63937_Performance%20of%20Stochastic%20Targeted%20Blood%20Glucose%20Control%20Protocol%20by%20virtual%20trials%20in%20the%20Malaysian%20intensive%20care%20unit_WOS.pdf

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spelling	iium-639372019-01-24T07:21:39Z http://irep.iium.edu.my/63937/ Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit Jamaludin, Ummu Kulthum Mohamad Suhaimi, Fatanah Abdul Razak, Normy Norfiza Md Ralib, Azrina Mat Nor, Mohd Basri Christopher, Pretty Luqman, Humaidi R Medicine (General) Background and objective: Blood glucose variability is common in healthcare and it is not related or influ- enced by diabetes mellitus. To minimise the risk of high blood glucose in critically ill patients, Stochastic Targeted Blood Glucose Control Protocol is used in intensive care unit at hospitals worldwide. Thus, this study focuses on the performance of stochastic modelling protocol in comparison to the current blood glucose management protocols in the Malaysian intensive care unit. Also, this study is to assess the ef- fectiveness of Stochastic Targeted Blood Glucose Control Protocol when it is applied to a cohort of diabetic patients. Methods: Retrospective data from 210 patients were obtained from a general hospital in Malaysia from May 2014 until June 2015, where 123 patients were having comorbid diabetes mellitus. The comparison of blood glucose control protocol performance between both protocol simulations was conducted through blood glucose fitted with physiological modelling on top of virtual trial simulations, mean calculation of simulation error and several graphical comparisons using stochastic modelling. Results: Stochastic Targeted Blood Glucose Control Protocol reduces hyperglycaemia by 16% in diabetic and 9% in nondiabetic cohorts. The protocol helps to control blood glucose level in the targeted range of 4.0–10.0 mmol/L for 71.8% in diabetic and 82.7% in nondiabetic cohorts, besides minimising the treatment hour up to 71 h for 123 diabetic patients and 39 h for 87 nondiabetic patients. Conclusion: It is concluded that Stochastic Targeted Blood Glucose Control Protocol is good in reducing hyperglycaemia as compared to the current blood glucose management protocol in the Malaysian inten- sive care unit. Hence, the current Malaysian intensive care unit protocols need to be modified to enhance their performance, especially in the integration of insulin and nutrition intervention in decreasing the hyperglycaemia incidences. Improvement in Stochastic Targeted Blood Glucose Control Protocol in terms of u en model is also a must to adapt with the diabetic cohort. Elsevier Ireland Ltd 2018-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63937/2/63937_Performance%20of%20Stochastic%20Targeted%20Blood.pdf application/pdf en http://irep.iium.edu.my/63937/1/63937_Performance%20of%20Stochastic%20Targeted%20_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/63937/13/63937_Performance%20of%20Stochastic%20Targeted%20Blood%20Glucose%20Control%20Protocol%20by%20virtual%20trials%20in%20the%20Malaysian%20intensive%20care%20unit_WOS.pdf Jamaludin, Ummu Kulthum and Mohamad Suhaimi, Fatanah and Abdul Razak, Normy Norfiza and Md Ralib, Azrina and Mat Nor, Mohd Basri and Christopher, Pretty and Luqman, Humaidi (2018) Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit. Computer Methods and Programs in Biomedicine, 162. pp. 149-155. ISSN 0169-2607 https://www.sciencedirect.com/science/article/pii/S0169260717306776 10.1016/j.cmpb.2018.03.001
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Jamaludin, Ummu Kulthum Mohamad Suhaimi, Fatanah Abdul Razak, Normy Norfiza Md Ralib, Azrina Mat Nor, Mohd Basri Christopher, Pretty Luqman, Humaidi Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit
description	Background and objective: Blood glucose variability is common in healthcare and it is not related or influ- enced by diabetes mellitus. To minimise the risk of high blood glucose in critically ill patients, Stochastic Targeted Blood Glucose Control Protocol is used in intensive care unit at hospitals worldwide. Thus, this study focuses on the performance of stochastic modelling protocol in comparison to the current blood glucose management protocols in the Malaysian intensive care unit. Also, this study is to assess the ef- fectiveness of Stochastic Targeted Blood Glucose Control Protocol when it is applied to a cohort of diabetic patients. Methods: Retrospective data from 210 patients were obtained from a general hospital in Malaysia from May 2014 until June 2015, where 123 patients were having comorbid diabetes mellitus. The comparison of blood glucose control protocol performance between both protocol simulations was conducted through blood glucose fitted with physiological modelling on top of virtual trial simulations, mean calculation of simulation error and several graphical comparisons using stochastic modelling. Results: Stochastic Targeted Blood Glucose Control Protocol reduces hyperglycaemia by 16% in diabetic and 9% in nondiabetic cohorts. The protocol helps to control blood glucose level in the targeted range of 4.0–10.0 mmol/L for 71.8% in diabetic and 82.7% in nondiabetic cohorts, besides minimising the treatment hour up to 71 h for 123 diabetic patients and 39 h for 87 nondiabetic patients. Conclusion: It is concluded that Stochastic Targeted Blood Glucose Control Protocol is good in reducing hyperglycaemia as compared to the current blood glucose management protocol in the Malaysian inten- sive care unit. Hence, the current Malaysian intensive care unit protocols need to be modified to enhance their performance, especially in the integration of insulin and nutrition intervention in decreasing the hyperglycaemia incidences. Improvement in Stochastic Targeted Blood Glucose Control Protocol in terms of u en model is also a must to adapt with the diabetic cohort.
format	Article
author	Jamaludin, Ummu Kulthum Mohamad Suhaimi, Fatanah Abdul Razak, Normy Norfiza Md Ralib, Azrina Mat Nor, Mohd Basri Christopher, Pretty Luqman, Humaidi
author_facet	Jamaludin, Ummu Kulthum Mohamad Suhaimi, Fatanah Abdul Razak, Normy Norfiza Md Ralib, Azrina Mat Nor, Mohd Basri Christopher, Pretty Luqman, Humaidi
author_sort	Jamaludin, Ummu Kulthum
title	Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit
title_short	Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit
title_full	Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit
title_fullStr	Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit
title_full_unstemmed	Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit
title_sort	performance of stochastic targeted blood glucose control protocol by virtual trials in the malaysian intensive care unit
publisher	Elsevier Ireland Ltd
publishDate	2018
url	http://irep.iium.edu.my/63937/ http://irep.iium.edu.my/63937/ http://irep.iium.edu.my/63937/ http://irep.iium.edu.my/63937/2/63937_Performance%20of%20Stochastic%20Targeted%20Blood.pdf http://irep.iium.edu.my/63937/1/63937_Performance%20of%20Stochastic%20Targeted%20_SCOPUS.pdf http://irep.iium.edu.my/63937/13/63937_Performance%20of%20Stochastic%20Targeted%20Blood%20Glucose%20Control%20Protocol%20by%20virtual%20trials%20in%20the%20Malaysian%20intensive%20care%20unit_WOS.pdf
first_indexed	2023-09-18T21:30:41Z
last_indexed	2023-09-18T21:30:41Z
_version_	1777412490530914304

Performance of stochastic targeted blood glucose control protocol by virtual trials in the Malaysian intensive care unit

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