DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients

AIM: This study examined catechol-O-methyltransferase (COMT) DNA methylation in the peripheral blood of schizophrenia patients and also in healthy controls to investigate its potential use as a peripheral biomarker of schizophrenia and its relations with the clinical variables of schizophrenia pa...

Full description

Bibliographic Details
Main Authors:	Abd Rahim, Nour El Huda, Ku Zaifah, Norsidah, Mohd Rahim, Nabil Fikri, Mohd Noor, Hanisah, Abdullah, Kartini, A.Talib, Norlelawati
Format:	Article
Language:	English English English English English
Published:	Wiley-Blackwell 2018
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/63786/ http://irep.iium.edu.my/63786/ http://irep.iium.edu.my/63786/ http://irep.iium.edu.my/63786/24/63786_DNA%20methylation%20of%20membrane-bound%20catechol-O-methyltransferase_article_new.pdf http://irep.iium.edu.my/63786/1/COMT%20DNA%20MEthylation.pdf http://irep.iium.edu.my/63786/12/63786_DNA%20methylation%20of%20membrane-bound%20catechol-O-methyltransferase_scopus.pdf http://irep.iium.edu.my/63786/29/63786_DNA%20methylation%20of%20membrane%E2%80%90bound%20catechol%E2%80%90O%E2%80%90methyltransferase%20_article.pdf http://irep.iium.edu.my/63786/35/63786%20DNA%20methylation%20of%20membrane-bound%20catechol-O-methyltransferase%20in%20Malaysian%20schizophrenia%20patients_wos.pdf

id	iium-63786
recordtype	eprints
spelling	iium-637862019-08-26T03:08:27Z http://irep.iium.edu.my/63786/ DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients Abd Rahim, Nour El Huda Ku Zaifah, Norsidah Mohd Rahim, Nabil Fikri Mohd Noor, Hanisah Abdullah, Kartini A.Talib, Norlelawati RM Therapeutics. Pharmacology AIM: This study examined catechol-O-methyltransferase (COMT) DNA methylation in the peripheral blood of schizophrenia patients and also in healthy controls to investigate its potential use as a peripheral biomarker of schizophrenia and its relations with the clinical variables of schizophrenia patients. METHODS: We examined the DNA methylation levels of COMT using genomic DNA from the peripheral blood of schizophrenia patients (n = 138) and healthy control participants (n = 132); all were Malaysian Malays. The extracted DNA was bisulfite converted, and the percentage methylation ratio value was calculated based on the results following a MethyLight protocol analysis. RESULTS: The percentage methylation ratio of COMT was lower in schizophrenia than it was in the healthy controls (P < 0.001) and was different between the body mass index (P = 0.003) and antipsychotic (P = 0.004) groups. The COMT DNA methylation rate was lower in patients receiving atypical antipsychotics (P = 0.004) and risperidone (P = 0.049) as compared to typical antipsychotics. The Excitement and Depressed subdomains of the Positive and Negative Syndrome Scale were inversely related (P < 0.001) and therefore predictors (Excitement: b = -11.396, t = -4.760, P < 0.001; Depressed: b = -7.789, t = -3.487, P = 0.001) of COMT DNA methylation. CONCLUSION: Our results suggested that the methylation level was affected by the severity of the clinical symptoms of schizophrenia and might also be influenced by pharmacological treatment. The epigenetic alteration of COMT in the peripheral blood could be a potential peripheral biomarker of schizophrenia. Wiley-Blackwell 2018-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63786/24/63786_DNA%20methylation%20of%20membrane-bound%20catechol-O-methyltransferase_article_new.pdf application/pdf en http://irep.iium.edu.my/63786/1/COMT%20DNA%20MEthylation.pdf application/pdf en http://irep.iium.edu.my/63786/12/63786_DNA%20methylation%20of%20membrane-bound%20catechol-O-methyltransferase_scopus.pdf application/pdf en http://irep.iium.edu.my/63786/29/63786_DNA%20methylation%20of%20membrane%E2%80%90bound%20catechol%E2%80%90O%E2%80%90methyltransferase%20_article.pdf application/pdf en http://irep.iium.edu.my/63786/35/63786%20DNA%20methylation%20of%20membrane-bound%20catechol-O-methyltransferase%20in%20Malaysian%20schizophrenia%20patients_wos.pdf Abd Rahim, Nour El Huda and Ku Zaifah, Norsidah and Mohd Rahim, Nabil Fikri and Mohd Noor, Hanisah and Abdullah, Kartini and A.Talib, Norlelawati (2018) DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients. Psychiatry and Clinical Neuroscience, 72 (4). pp. 266-279. ISSN 1323-1316 E-ISSN 1440-1819 https://onlinelibrary.wiley.com/journal/14401819 10.1111/pcn.12622
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Abd Rahim, Nour El Huda Ku Zaifah, Norsidah Mohd Rahim, Nabil Fikri Mohd Noor, Hanisah Abdullah, Kartini A.Talib, Norlelawati DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients
description	AIM: This study examined catechol-O-methyltransferase (COMT) DNA methylation in the peripheral blood of schizophrenia patients and also in healthy controls to investigate its potential use as a peripheral biomarker of schizophrenia and its relations with the clinical variables of schizophrenia patients. METHODS: We examined the DNA methylation levels of COMT using genomic DNA from the peripheral blood of schizophrenia patients (n = 138) and healthy control participants (n = 132); all were Malaysian Malays. The extracted DNA was bisulfite converted, and the percentage methylation ratio value was calculated based on the results following a MethyLight protocol analysis. RESULTS: The percentage methylation ratio of COMT was lower in schizophrenia than it was in the healthy controls (P < 0.001) and was different between the body mass index (P = 0.003) and antipsychotic (P = 0.004) groups. The COMT DNA methylation rate was lower in patients receiving atypical antipsychotics (P = 0.004) and risperidone (P = 0.049) as compared to typical antipsychotics. The Excitement and Depressed subdomains of the Positive and Negative Syndrome Scale were inversely related (P < 0.001) and therefore predictors (Excitement: b = -11.396, t = -4.760, P < 0.001; Depressed: b = -7.789, t = -3.487, P = 0.001) of COMT DNA methylation. CONCLUSION: Our results suggested that the methylation level was affected by the severity of the clinical symptoms of schizophrenia and might also be influenced by pharmacological treatment. The epigenetic alteration of COMT in the peripheral blood could be a potential peripheral biomarker of schizophrenia.
format	Article
author	Abd Rahim, Nour El Huda Ku Zaifah, Norsidah Mohd Rahim, Nabil Fikri Mohd Noor, Hanisah Abdullah, Kartini A.Talib, Norlelawati
author_facet	Abd Rahim, Nour El Huda Ku Zaifah, Norsidah Mohd Rahim, Nabil Fikri Mohd Noor, Hanisah Abdullah, Kartini A.Talib, Norlelawati
author_sort	Abd Rahim, Nour El Huda
title	DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients
title_short	DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients
title_full	DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients
title_fullStr	DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients
title_full_unstemmed	DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients
title_sort	dna methylation of membrane-bound catechol-o-methyltransferase in malaysian schizophrenia patients
publisher	Wiley-Blackwell
publishDate	2018
url	http://irep.iium.edu.my/63786/ http://irep.iium.edu.my/63786/ http://irep.iium.edu.my/63786/ http://irep.iium.edu.my/63786/24/63786_DNA%20methylation%20of%20membrane-bound%20catechol-O-methyltransferase_article_new.pdf http://irep.iium.edu.my/63786/1/COMT%20DNA%20MEthylation.pdf http://irep.iium.edu.my/63786/12/63786_DNA%20methylation%20of%20membrane-bound%20catechol-O-methyltransferase_scopus.pdf http://irep.iium.edu.my/63786/29/63786_DNA%20methylation%20of%20membrane%E2%80%90bound%20catechol%E2%80%90O%E2%80%90methyltransferase%20_article.pdf http://irep.iium.edu.my/63786/35/63786%20DNA%20methylation%20of%20membrane-bound%20catechol-O-methyltransferase%20in%20Malaysian%20schizophrenia%20patients_wos.pdf
first_indexed	2023-09-18T21:30:28Z
last_indexed	2023-09-18T21:30:28Z
_version_	1777412476646719488

DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients

Similar Items