2VO as affordable model for neurodegeneration- IIUM experience

Reduced cerebral blood flow to the brain tissue is usually associated with cognitive weakening in aging people and can lead to development of neurodegenerative disorder pathologically similar to Alzheimer’s disease. While an accidental interruption of the cerebral blood circulation (acute) can lead...

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Main Author:	Allow, Ahmed Kaid Naji
Format:	Conference or Workshop Item
Language:	English
Published:	2018
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/63675/ http://irep.iium.edu.my/63675/ http://irep.iium.edu.my/63675/7/63675_2VO%20as%20affordable%20Model%20for_complete.pdf

id	iium-63675
recordtype	eprints
spelling	iium-636752018-05-17T06:42:52Z http://irep.iium.edu.my/63675/ 2VO as affordable model for neurodegeneration- IIUM experience Allow, Ahmed Kaid Naji QP Physiology Reduced cerebral blood flow to the brain tissue is usually associated with cognitive weakening in aging people and can lead to development of neurodegenerative disorder pathologically similar to Alzheimer’s disease. While an accidental interruption of the cerebral blood circulation (acute) can lead to the clinicopathological disorder called stroke, the gradual reduction of cerebral blood flow impairs memory processes and culminates in the appearance of dementia manifested by both neurological and psychiatric. Permanent bilateral ligation of the common carotid arteries, also known as 2 vessel occlusion (2VO), has been established as a model to investigate the effects of chronic cerebral hypoperfusion on development of neurodegenerative processes. There are several phases that follow 2VO. The acute phase takes place during the first 2-3 days after operation. In this phase, reduction of cerebral blood flow can reach up to 50%. In the chronic phase, which extends to 10-12 weeks after 2VO operation, the neurodegeneration has already happened but the cerebral blood flow might be back to normal. In this session of Neuroscience Symposium-II 2018, we will talk about IIUM/KOM/BMS experience regarding 2VO as an animal model of neurodegeneration. Some of the research projects that were done in BMS over the past few years will be presented focusing on work published by our Master and PhD students in indexed peer-reviewed journals. One of the PG students will demonstrate his experience with 2VO. Based on the IIUM/KOM/BMS experience, the difficulties encountered in performing 2VO and the survival rate of adult rats that have undergone the procedure will be highlighted too. 2018-05-02 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/63675/7/63675_2VO%20as%20affordable%20Model%20for_complete.pdf Allow, Ahmed Kaid Naji (2018) 2VO as affordable model for neurodegeneration- IIUM experience. In: Neuroscience Symposium 2018 BMS KOM IIUM 2nd May 2018, 2 May 2018, KOM Level 4 conference room, International Islamic University Malaysia. (Unpublished) http://www.iium.edu.my/my
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology
spellingShingle	QP Physiology Allow, Ahmed Kaid Naji 2VO as affordable model for neurodegeneration- IIUM experience
description	Reduced cerebral blood flow to the brain tissue is usually associated with cognitive weakening in aging people and can lead to development of neurodegenerative disorder pathologically similar to Alzheimer’s disease. While an accidental interruption of the cerebral blood circulation (acute) can lead to the clinicopathological disorder called stroke, the gradual reduction of cerebral blood flow impairs memory processes and culminates in the appearance of dementia manifested by both neurological and psychiatric. Permanent bilateral ligation of the common carotid arteries, also known as 2 vessel occlusion (2VO), has been established as a model to investigate the effects of chronic cerebral hypoperfusion on development of neurodegenerative processes. There are several phases that follow 2VO. The acute phase takes place during the first 2-3 days after operation. In this phase, reduction of cerebral blood flow can reach up to 50%. In the chronic phase, which extends to 10-12 weeks after 2VO operation, the neurodegeneration has already happened but the cerebral blood flow might be back to normal. In this session of Neuroscience Symposium-II 2018, we will talk about IIUM/KOM/BMS experience regarding 2VO as an animal model of neurodegeneration. Some of the research projects that were done in BMS over the past few years will be presented focusing on work published by our Master and PhD students in indexed peer-reviewed journals. One of the PG students will demonstrate his experience with 2VO. Based on the IIUM/KOM/BMS experience, the difficulties encountered in performing 2VO and the survival rate of adult rats that have undergone the procedure will be highlighted too.
format	Conference or Workshop Item
author	Allow, Ahmed Kaid Naji
author_facet	Allow, Ahmed Kaid Naji
author_sort	Allow, Ahmed Kaid Naji
title	2VO as affordable model for neurodegeneration- IIUM experience
title_short	2VO as affordable model for neurodegeneration- IIUM experience
title_full	2VO as affordable model for neurodegeneration- IIUM experience
title_fullStr	2VO as affordable model for neurodegeneration- IIUM experience
title_full_unstemmed	2VO as affordable model for neurodegeneration- IIUM experience
title_sort	2vo as affordable model for neurodegeneration- iium experience
publishDate	2018
url	http://irep.iium.edu.my/63675/ http://irep.iium.edu.my/63675/ http://irep.iium.edu.my/63675/7/63675_2VO%20as%20affordable%20Model%20for_complete.pdf
first_indexed	2023-09-18T21:30:17Z
last_indexed	2023-09-18T21:30:17Z
_version_	1777412465232969728

2VO as affordable model for neurodegeneration- IIUM experience

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