Identification of MSX1 mutation in Malaysian hypodontia family
Hypodontia is defined as the absence of one to six teeth. There is high prevalence of hypodontia recorded in Malaysia (2.8%). This study aimed to identify any mutation of MSX1 in Malaysian family with hypodontia and its clinical finding. We re-examined 4 individuals from a family of the previou...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Atlantis Press
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/63481/ http://irep.iium.edu.my/63481/ http://irep.iium.edu.my/63481/ http://irep.iium.edu.my/63481/1/63841_Identification%20of%20MSX1%20mutation%20in%20Malaysian%20hypodontia%20family.pdf |
| Summary: | Hypodontia is defined as the absence of one
to six teeth. There is high prevalence of hypodontia
recorded in Malaysia (2.8%). This study aimed to identify
any mutation of MSX1 in Malaysian family with
hypodontia and its clinical finding. We re-examined 4
individuals from a family of the previous PAX9 study.
Orthophantomogram (OPG) and intraoral photos were
re-assessed. Saliva was collected for genetic analysis.
Direct sequencing was done on exons 1 and 2 of MSX1. 2
out of 4 members (1A and 1D) in the family have anterior
hypodontia. Point mutation on exon1 of MSX1 (c.731G>A)
was observed in 1A (father) with missing 13 and 23 and
1C (carrier-son). c.732G>A was found on exon1 of MSX1
of his daughter (1D) with missing 32.MSX1 mutation is
involved in the occurrence of hypodontia in patient. |
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