The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings

Introduction: Hypertension related morbidities and mortalities around the world show a gradual increase and early detection and prevention are advocated. The Database of Genomic Variants (DGV) has associated variation in DNA sequences called copy number variation (CNV) with susceptibility...

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Main Authors:	Shaik Alaudeen, Siti Radziah, Mohd Shah, Azarisman Shah, A.Talib, Norlelawati, Abdullah, Aszrin
Format:	Article
Language:	English
Published:	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia. 2017
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://irep.iium.edu.my/63474/ http://irep.iium.edu.my/63474/ http://irep.iium.edu.my/63474/1/Abstract-Book-for-IMJM-final-v2-37.pdf

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spelling	iium-634742018-08-30T03:02:46Z http://irep.iium.edu.my/63474/ The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings Shaik Alaudeen, Siti Radziah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Abdullah, Aszrin R Medicine (General) RB Pathology Introduction: Hypertension related morbidities and mortalities around the world show a gradual increase and early detection and prevention are advocated. The Database of Genomic Variants (DGV) has associated variation in DNA sequences called copy number variation (CNV) with susceptibility to common diseases. However, little is known about CNV role in essential hypertension. Thus, this study aimed to characterize the CNV esv27061 among prehypertensive and hypertensive young adults in Malaysia. Materials and method: In this comparative cross-sectional study, 104 subjects living in Kuantan who gave voluntary consent to participate are recruited and divided into three groups; control (43 subjects), prehypertensive (38 subjects) and mild hypertensive (23 subjects). An optimized droplet digital polymerase chain reaction (ddPCR) was used in the determination of CNV esv27061 in this study. Results: All subjects in the control (n=38; 88.4% gain), prehypertensive (n=33; 86.8% gain) and mild hypertensive (n=21; 91.3% gain) groups had CNV gain (copy number > 2) while 11.6% of control, 13.2% of prehypertensive and 8.7% of mild hypertensive subjects exhibited normal copies (copy number = 2). Conclusion: The present preliminary finding was consistent with the Database of Genomic Variants (DGV) which stated that CNV esv27061 showedmore gain than loss. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia. 2017-09-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63474/1/Abstract-Book-for-IMJM-final-v2-37.pdf Shaik Alaudeen, Siti Radziah and Mohd Shah, Azarisman Shah and A.Talib, Norlelawati and Abdullah, Aszrin (2017) The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings. International Medical Journal Malaysia, 16 (Supplementary Issue 1). p. 31. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2016%20No%201%20Supp%201/Abstract-Book-for-IMJM-final-v2-37.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Shaik Alaudeen, Siti Radziah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Abdullah, Aszrin The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings
description	Introduction: Hypertension related morbidities and mortalities around the world show a gradual increase and early detection and prevention are advocated. The Database of Genomic Variants (DGV) has associated variation in DNA sequences called copy number variation (CNV) with susceptibility to common diseases. However, little is known about CNV role in essential hypertension. Thus, this study aimed to characterize the CNV esv27061 among prehypertensive and hypertensive young adults in Malaysia. Materials and method: In this comparative cross-sectional study, 104 subjects living in Kuantan who gave voluntary consent to participate are recruited and divided into three groups; control (43 subjects), prehypertensive (38 subjects) and mild hypertensive (23 subjects). An optimized droplet digital polymerase chain reaction (ddPCR) was used in the determination of CNV esv27061 in this study. Results: All subjects in the control (n=38; 88.4% gain), prehypertensive (n=33; 86.8% gain) and mild hypertensive (n=21; 91.3% gain) groups had CNV gain (copy number > 2) while 11.6% of control, 13.2% of prehypertensive and 8.7% of mild hypertensive subjects exhibited normal copies (copy number = 2). Conclusion: The present preliminary finding was consistent with the Database of Genomic Variants (DGV) which stated that CNV esv27061 showedmore gain than loss.
format	Article
author	Shaik Alaudeen, Siti Radziah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Abdullah, Aszrin
author_facet	Shaik Alaudeen, Siti Radziah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Abdullah, Aszrin
author_sort	Shaik Alaudeen, Siti Radziah
title	The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings
title_short	The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings
title_full	The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings
title_fullStr	The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings
title_full_unstemmed	The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings
title_sort	identification of copy number variation of cnv esv27061 among young adults with hypertension: preliminary findings
publisher	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia.
publishDate	2017
url	http://irep.iium.edu.my/63474/ http://irep.iium.edu.my/63474/ http://irep.iium.edu.my/63474/1/Abstract-Book-for-IMJM-final-v2-37.pdf
first_indexed	2023-09-18T21:30:02Z
last_indexed	2023-09-18T21:30:02Z
_version_	1777412448760889344

The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings

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