A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity

Callophylum symingtonianum (Guttiferae), an evergreen broad-leaved tree that usually grows in hill forests, can be found distributed in the Malay Peninsula. The barks, leaves, flowers and seeds is often used medicinally to treat diarrhea and rheumatism. In the present study, we isolated two inophyll...

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Main Authors:	Darnis, Deny Susanti, Attoumani, Nissad, Bakhtiar, M. Taher, Rezali, Mohd Fazlin, Sohrab, Md Hossain, Hasan, Choudhury Mahmood, Zakaria, Zainul Amiruddin
Format:	Article
Language:	English English
Published:	Korean Society of Pharmacognosy 2018
Subjects:	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/63468/ http://irep.iium.edu.my/63468/ http://irep.iium.edu.my/63468/ http://irep.iium.edu.my/63468/1/Nat%20Prod%20Sci%202018.pdf http://irep.iium.edu.my/63468/7/63468_A%20Conformational%20Isomer%20of%20Soulattrolide%20from%20the%20Stem%20Bark_scopus.pdf

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recordtype	eprints
spelling	iium-634682018-04-30T03:34:20Z http://irep.iium.edu.my/63468/ A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity Darnis, Deny Susanti Attoumani, Nissad Bakhtiar, M. Taher Rezali, Mohd Fazlin Sohrab, Md Hossain Hasan, Choudhury Mahmood Zakaria, Zainul Amiruddin RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Callophylum symingtonianum (Guttiferae), an evergreen broad-leaved tree that usually grows in hill forests, can be found distributed in the Malay Peninsula. The barks, leaves, flowers and seeds is often used medicinally to treat diarrhea and rheumatism. In the present study, we isolated two inophyllum type coumarins, 12-O-ethylinophyllum D (1) and iso-soulattrolide (2) from the stembarks of C. symingtonianum together with their antibacterial activity. The compounds were isolated by chromatographic methods on a silica gel. The structures were established by spectroscopic methods including UV, IR, (1D and 2D) NMR and mass spectrometry as well as by comparison with several literature sources. The antibacterial activity of those compounds was tested using a disc-diffusion assay against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Both compound exhibited mild inhibition against P. aeruginosa with both 111 µg/ml MIC value. Compound 2 also inhibits S. aureus with 25 µg/ml MIC value. Korean Society of Pharmacognosy 2018-04-19 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63468/1/Nat%20Prod%20Sci%202018.pdf application/pdf en http://irep.iium.edu.my/63468/7/63468_A%20Conformational%20Isomer%20of%20Soulattrolide%20from%20the%20Stem%20Bark_scopus.pdf Darnis, Deny Susanti and Attoumani, Nissad and Bakhtiar, M. Taher and Rezali, Mohd Fazlin and Sohrab, Md Hossain and Hasan, Choudhury Mahmood and Zakaria, Zainul Amiruddin (2018) A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity. Natural Product Sciences, 24 (1). pp. 47-53. ISSN 1226-3907 E-ISSN 2288-9027 http://www.e-nps.or.kr/ 10.20307/nps.2018.24.1.47
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Darnis, Deny Susanti Attoumani, Nissad Bakhtiar, M. Taher Rezali, Mohd Fazlin Sohrab, Md Hossain Hasan, Choudhury Mahmood Zakaria, Zainul Amiruddin A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity
description	Callophylum symingtonianum (Guttiferae), an evergreen broad-leaved tree that usually grows in hill forests, can be found distributed in the Malay Peninsula. The barks, leaves, flowers and seeds is often used medicinally to treat diarrhea and rheumatism. In the present study, we isolated two inophyllum type coumarins, 12-O-ethylinophyllum D (1) and iso-soulattrolide (2) from the stembarks of C. symingtonianum together with their antibacterial activity. The compounds were isolated by chromatographic methods on a silica gel. The structures were established by spectroscopic methods including UV, IR, (1D and 2D) NMR and mass spectrometry as well as by comparison with several literature sources. The antibacterial activity of those compounds was tested using a disc-diffusion assay against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Both compound exhibited mild inhibition against P. aeruginosa with both 111 µg/ml MIC value. Compound 2 also inhibits S. aureus with 25 µg/ml MIC value.
format	Article
author	Darnis, Deny Susanti Attoumani, Nissad Bakhtiar, M. Taher Rezali, Mohd Fazlin Sohrab, Md Hossain Hasan, Choudhury Mahmood Zakaria, Zainul Amiruddin
author_facet	Darnis, Deny Susanti Attoumani, Nissad Bakhtiar, M. Taher Rezali, Mohd Fazlin Sohrab, Md Hossain Hasan, Choudhury Mahmood Zakaria, Zainul Amiruddin
author_sort	Darnis, Deny Susanti
title	A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity
title_short	A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity
title_full	A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity
title_fullStr	A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity
title_full_unstemmed	A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity
title_sort	conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity
publisher	Korean Society of Pharmacognosy
publishDate	2018
url	http://irep.iium.edu.my/63468/ http://irep.iium.edu.my/63468/ http://irep.iium.edu.my/63468/ http://irep.iium.edu.my/63468/1/Nat%20Prod%20Sci%202018.pdf http://irep.iium.edu.my/63468/7/63468_A%20Conformational%20Isomer%20of%20Soulattrolide%20from%20the%20Stem%20Bark_scopus.pdf
first_indexed	2023-09-18T21:30:01Z
last_indexed	2023-09-18T21:30:01Z
_version_	1777412448024788992

A conformational isomer of soulattrolide from the stem bark of calophyllum symingtonianum and its antibacterial activity

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