Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
King Saud University
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/ http://irep.iium.edu.my/62988/1/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_article.pdf http://irep.iium.edu.my/62988/2/62988_Novel%20essential%20amino%20acid-sulfanilamide%20hybrid%20_scopus.pdf |
| Summary: | A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging. |
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