Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution

This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the ra...

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Main Authors:	Mohammad, Khairool Azizul, Abd Rahim, Syarifah, Abu Bakar, Mohd Rushdi
Format:	Article
Language:	English English English English
Published:	Springer Netherlands 2017
Subjects:	TP155 Chemical engineering
Online Access:	http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/1/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_article.pdf http://irep.iium.edu.my/62951/2/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_scopus.pdf http://irep.iium.edu.my/62951/13/2017_J_Therm_Anal_Calorim_rushdi.pdf http://irep.iium.edu.my/62951/15/s10973-017-6483-1

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spelling	iium-629512019-07-15T01:59:15Z http://irep.iium.edu.my/62951/ Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution Mohammad, Khairool Azizul Abd Rahim, Syarifah Abu Bakar, Mohd Rushdi TP155 Chemical engineering This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the radius of the critical nucleus and the interfacial energy of the CBZ–SAC co-crystals via fast cooling. Slow cooling experiments with cooling/heating rates of 0.8, 0.6, 0.4 and 0.2 °C min−1 were applied to determine the crystallisation and the dissolution temperature of CBZ–SAC co-crystals at SAC:CBZ ratios of (3.5, 3.0, 2.5, 2.0 and 1.0) and CBZ concentrations of 19.14, 17.96, 17.06 and 15.83 mg mL−1. Then, fast cooling experiments were run at CBZ concentration of 17.96 mg mL−1 and SAC:CBZ mole ratio of 2.0. Nucleation kinetics, such as MSZW, nucleation order, nucleation kinetic constant and interfacial energy, was determined and analysed. KBHR method was applied to analyse the kinetics value and compared with isothermal method. The nucleation orders obtained from slow cooling method were in between 1.65 and 4.9, which were within the range for nucleation of organic compounds. The results of KBHR method in determining the kinetic values of CBZ–SAC co-crystals were similar to those of the isothermal method. Springer Netherlands 2017-12-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62951/1/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_article.pdf application/pdf en http://irep.iium.edu.my/62951/2/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_scopus.pdf application/pdf en http://irep.iium.edu.my/62951/13/2017_J_Therm_Anal_Calorim_rushdi.pdf application/pdf en http://irep.iium.edu.my/62951/15/s10973-017-6483-1 Mohammad, Khairool Azizul and Abd Rahim, Syarifah and Abu Bakar, Mohd Rushdi (2017) Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution. Journal of Thermal Analysis and Calorimetry, 130 (3). pp. 1663-1669. ISSN 1388-6150 E-ISSN 1588-2926 https://link.springer.com/article/10.1007/s10973-017-6483-1 10.1007/s10973-017-6483-1
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	TP155 Chemical engineering
spellingShingle	TP155 Chemical engineering Mohammad, Khairool Azizul Abd Rahim, Syarifah Abu Bakar, Mohd Rushdi Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution
description	This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the radius of the critical nucleus and the interfacial energy of the CBZ–SAC co-crystals via fast cooling. Slow cooling experiments with cooling/heating rates of 0.8, 0.6, 0.4 and 0.2 °C min−1 were applied to determine the crystallisation and the dissolution temperature of CBZ–SAC co-crystals at SAC:CBZ ratios of (3.5, 3.0, 2.5, 2.0 and 1.0) and CBZ concentrations of 19.14, 17.96, 17.06 and 15.83 mg mL−1. Then, fast cooling experiments were run at CBZ concentration of 17.96 mg mL−1 and SAC:CBZ mole ratio of 2.0. Nucleation kinetics, such as MSZW, nucleation order, nucleation kinetic constant and interfacial energy, was determined and analysed. KBHR method was applied to analyse the kinetics value and compared with isothermal method. The nucleation orders obtained from slow cooling method were in between 1.65 and 4.9, which were within the range for nucleation of organic compounds. The results of KBHR method in determining the kinetic values of CBZ–SAC co-crystals were similar to those of the isothermal method.
format	Article
author	Mohammad, Khairool Azizul Abd Rahim, Syarifah Abu Bakar, Mohd Rushdi
author_facet	Mohammad, Khairool Azizul Abd Rahim, Syarifah Abu Bakar, Mohd Rushdi
author_sort	Mohammad, Khairool Azizul
title	Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution
title_short	Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution
title_full	Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution
title_fullStr	Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution
title_full_unstemmed	Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution
title_sort	kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution
publisher	Springer Netherlands
publishDate	2017
url	http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/ http://irep.iium.edu.my/62951/1/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_article.pdf http://irep.iium.edu.my/62951/2/62951_Kinetics%20and%20nucleation%20mechanism%20of%20carbamazepine_scopus.pdf http://irep.iium.edu.my/62951/13/2017_J_Therm_Anal_Calorim_rushdi.pdf http://irep.iium.edu.my/62951/15/s10973-017-6483-1
first_indexed	2023-09-18T21:29:13Z
last_indexed	2023-09-18T21:29:13Z
_version_	1777412397497057280

Kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution

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