Serum leptin might be causally correlated to invasive ductal breast carcinoma

Introduction: Leptin, the hormone secreted from white adipose tissue is suspected of being a causative factor in tumorigenesis invarious tissues. Thus it might be a link between obesity and breastcancer. Objectives: In this project we tried to study causative association ofobesity and serum le...

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Main Authors:	Al-Shibli, Saad M., Amjad, Nasser Muhammad, Al-Kubaisi, Muna Khaleel Dheyab, Harun, Norra, Nafie, Emad M., Mizan, Shaikh
Format:	Article
Language:	English
Published:	SciTechnol 2018
Subjects:	RD Surgery RG Gynecology and obstetrics
Online Access:	http://irep.iium.edu.my/62637/ http://irep.iium.edu.my/62637/ http://irep.iium.edu.my/62637/ http://irep.iium.edu.my/62637/1/serum-leptin-might-be-causally-correlated-to-invasive-ductal-breast-carcinoma-xrsy.pdf

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spelling	iium-626372018-04-03T08:32:01Z http://irep.iium.edu.my/62637/ Serum leptin might be causally correlated to invasive ductal breast carcinoma Al-Shibli, Saad M. Amjad, Nasser Muhammad Al-Kubaisi, Muna Khaleel Dheyab Harun, Norra Nafie, Emad M. Mizan, Shaikh RD Surgery RG Gynecology and obstetrics Introduction: Leptin, the hormone secreted from white adipose tissue is suspected of being a causative factor in tumorigenesis invarious tissues. Thus it might be a link between obesity and breastcancer. Objectives: In this project we tried to study causative association ofobesity and serum leptin with invasive ductal breast cancer (IDC) in a sample of Malaysian population. Methods: We measured various obesity parameters, and estimated serum leptin levels in a group of healthy control and IDC patients.After confirming diagnosis by standard histopathological methods, serum leptin levels were estimated using ELISA. Both the pre-and postoperative leptin levels were measured with the Patient group. Results: The difference between the serum leptin levels of the Control and the Patient group were highly significant with a P value of < 0.001. There was no significant difference in the serum leptin level between the pre and post-operative states in the IDC patients (P=0.414).There was a significant positive correlation between the serum leptin level and the Body Mass Index (BMI) with the Control group (rs =0.598, P < 0.01), however, the breast cancer cases showed a very weakly positive correlation (r= 0.217, P > 0.05). Conclusion: Since high serum leptin in IDC patients persists unabated in the post-operative state, we infer that the source of leptin in these cases cannot be the breast cancer tissue itself and leptin cannot be a marker for breast cancer. Highly significant association between serum leptin and IDC patients suggests that leptin in serum might play a causative role in the tumorigenesis of breast cancer, and it might be an important connection between obesity and breast cancer. Therefore, leptin signal transduction pathway might be a prospective therapeutic target in the treatment and prevention of IDC. SciTechnol 2018-02-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62637/1/serum-leptin-might-be-causally-correlated-to-invasive-ductal-breast-carcinoma-xrsy.pdf Al-Shibli, Saad M. and Amjad, Nasser Muhammad and Al-Kubaisi, Muna Khaleel Dheyab and Harun, Norra and Nafie, Emad M. and Mizan, Shaikh (2018) Serum leptin might be causally correlated to invasive ductal breast carcinoma. Journal of Clinical & Experimental Oncology, 7 (1). pp. 1-5. ISSN 2324-9110 https://www.scitechnol.com/peer-review/serum-leptin-might-be-causally-correlated-to-invasive-ductal-breast-carcinoma-orWS.php?article_id=7244 10.4172/2324-9110.1000211
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD Surgery RG Gynecology and obstetrics
spellingShingle	RD Surgery RG Gynecology and obstetrics Al-Shibli, Saad M. Amjad, Nasser Muhammad Al-Kubaisi, Muna Khaleel Dheyab Harun, Norra Nafie, Emad M. Mizan, Shaikh Serum leptin might be causally correlated to invasive ductal breast carcinoma
description	Introduction: Leptin, the hormone secreted from white adipose tissue is suspected of being a causative factor in tumorigenesis invarious tissues. Thus it might be a link between obesity and breastcancer. Objectives: In this project we tried to study causative association ofobesity and serum leptin with invasive ductal breast cancer (IDC) in a sample of Malaysian population. Methods: We measured various obesity parameters, and estimated serum leptin levels in a group of healthy control and IDC patients.After confirming diagnosis by standard histopathological methods, serum leptin levels were estimated using ELISA. Both the pre-and postoperative leptin levels were measured with the Patient group. Results: The difference between the serum leptin levels of the Control and the Patient group were highly significant with a P value of < 0.001. There was no significant difference in the serum leptin level between the pre and post-operative states in the IDC patients (P=0.414).There was a significant positive correlation between the serum leptin level and the Body Mass Index (BMI) with the Control group (rs =0.598, P < 0.01), however, the breast cancer cases showed a very weakly positive correlation (r= 0.217, P > 0.05). Conclusion: Since high serum leptin in IDC patients persists unabated in the post-operative state, we infer that the source of leptin in these cases cannot be the breast cancer tissue itself and leptin cannot be a marker for breast cancer. Highly significant association between serum leptin and IDC patients suggests that leptin in serum might play a causative role in the tumorigenesis of breast cancer, and it might be an important connection between obesity and breast cancer. Therefore, leptin signal transduction pathway might be a prospective therapeutic target in the treatment and prevention of IDC.
format	Article
author	Al-Shibli, Saad M. Amjad, Nasser Muhammad Al-Kubaisi, Muna Khaleel Dheyab Harun, Norra Nafie, Emad M. Mizan, Shaikh
author_facet	Al-Shibli, Saad M. Amjad, Nasser Muhammad Al-Kubaisi, Muna Khaleel Dheyab Harun, Norra Nafie, Emad M. Mizan, Shaikh
author_sort	Al-Shibli, Saad M.
title	Serum leptin might be causally correlated to invasive ductal breast carcinoma
title_short	Serum leptin might be causally correlated to invasive ductal breast carcinoma
title_full	Serum leptin might be causally correlated to invasive ductal breast carcinoma
title_fullStr	Serum leptin might be causally correlated to invasive ductal breast carcinoma
title_full_unstemmed	Serum leptin might be causally correlated to invasive ductal breast carcinoma
title_sort	serum leptin might be causally correlated to invasive ductal breast carcinoma
publisher	SciTechnol
publishDate	2018
url	http://irep.iium.edu.my/62637/ http://irep.iium.edu.my/62637/ http://irep.iium.edu.my/62637/ http://irep.iium.edu.my/62637/1/serum-leptin-might-be-causally-correlated-to-invasive-ductal-breast-carcinoma-xrsy.pdf
first_indexed	2023-09-18T21:28:45Z
last_indexed	2023-09-18T21:28:45Z
_version_	1777412368759783424

Serum leptin might be causally correlated to invasive ductal breast carcinoma

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