Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities
Polygonumins A, a new compound, was isolated from the stem of Polygonum minus. Based on NMR results, the compound’s structure is identical to that of vanicoside A, comprising four phenylpropanoid ester units and a sucrose unit. The structure diferences were located at C-3″″′. The cytotoxic activity...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Nature Publishing Group
2018
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/62635/ http://irep.iium.edu.my/62635/ http://irep.iium.edu.my/62635/ http://irep.iium.edu.my/62635/7/62635%20Polygonumins%20A%2C%20a%20newly%20isolated%20SCOPUS.pdf http://irep.iium.edu.my/62635/13/62635_Polygonumins%20A%2C%20a%20newly%20isolated%20compound.pdf http://irep.iium.edu.my/62635/14/62635_Polygonumins%20A%2C%20a%20newly%20isolated%20compound_WOS.pdf |
| id |
iium-62635 |
|---|---|
| recordtype |
eprints |
| spelling |
iium-626352018-07-10T10:07:35Z http://irep.iium.edu.my/62635/ Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities Ahmad, Rafidah Sahidin, I. Bakhtiar, M. Taher Low, Chen Fei Mohd Noor, Normah Sillapachaiyaporn, Chanin Chuchawankul, Siriporn Sarachana, Tewarit Tencomnao, Tewin Iskandar, Faizah Rajab, Nor Fadilah Baharum, Syarul Nataqain RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Polygonumins A, a new compound, was isolated from the stem of Polygonum minus. Based on NMR results, the compound’s structure is identical to that of vanicoside A, comprising four phenylpropanoid ester units and a sucrose unit. The structure diferences were located at C-3″″′. The cytotoxic activity of polygonumins A was evaluated on several cancer cell lines by a cell viability assay using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). The compound showed the highest antiproliferative (p<0.05) activities against K562 (Human Leukaemia Cell Line), MCF7 (Human breast adenocarcinoma cell line), and HCT116 (Colorectal cancer cells) cells. Cytotoxic studies against V79–4 cells were carried out and showed that polygonumins A was toxic at 50µg/ml, suggesting that this compound may be used as an anticancer drug without afecting normal cells. Polygonumins A also showed promising activity as an HIV-1 protease inhibitor with 56% relative inhibition. Molecular docking results indicated that the compound possesses high binding afnity towards the HIV protease over the low binding free energy range of -10.5 to -11.3kcal/mol. P. minus is used in Malaysian traditional medicine for the treatment of tumour cells. This is the frst report on the use of P. minus as an HIV-1 protease inhibitor. Nature Publishing Group 2018-03-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62635/7/62635%20Polygonumins%20A%2C%20a%20newly%20isolated%20SCOPUS.pdf application/pdf en http://irep.iium.edu.my/62635/13/62635_Polygonumins%20A%2C%20a%20newly%20isolated%20compound.pdf application/pdf en http://irep.iium.edu.my/62635/14/62635_Polygonumins%20A%2C%20a%20newly%20isolated%20compound_WOS.pdf Ahmad, Rafidah and Sahidin, I. and Bakhtiar, M. Taher and Low, Chen Fei and Mohd Noor, Normah and Sillapachaiyaporn, Chanin and Chuchawankul, Siriporn and Sarachana, Tewarit and Tencomnao, Tewin and Iskandar, Faizah and Rajab, Nor Fadilah and Baharum, Syarul Nataqain (2018) Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities. Scientific Report, 8 (1). pp. 1-15. E-ISSN 2045-2322 https://www.nature.com/articles/s41598-018-22485-5.pdf 10.1038/s41598-018-22485-5 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English English |
| topic |
RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology |
| spellingShingle |
RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Ahmad, Rafidah Sahidin, I. Bakhtiar, M. Taher Low, Chen Fei Mohd Noor, Normah Sillapachaiyaporn, Chanin Chuchawankul, Siriporn Sarachana, Tewarit Tencomnao, Tewin Iskandar, Faizah Rajab, Nor Fadilah Baharum, Syarul Nataqain Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities |
| description |
Polygonumins A, a new compound, was isolated from the stem of Polygonum minus. Based on NMR results, the compound’s structure is identical to that of vanicoside A, comprising four phenylpropanoid ester units and a sucrose unit. The structure diferences were located at C-3″″′. The cytotoxic activity
of polygonumins A was evaluated on several cancer cell lines by a cell viability assay using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). The compound showed the
highest antiproliferative (p<0.05) activities against K562 (Human Leukaemia Cell Line), MCF7 (Human breast adenocarcinoma cell line), and HCT116 (Colorectal cancer cells) cells. Cytotoxic studies against V79–4 cells were carried out and showed that polygonumins A was toxic at 50µg/ml, suggesting that
this compound may be used as an anticancer drug without afecting normal cells. Polygonumins A also showed promising activity as an HIV-1 protease inhibitor with 56% relative inhibition. Molecular docking results indicated that the compound possesses high binding afnity towards the HIV protease over the low binding free energy range of -10.5 to -11.3kcal/mol. P. minus is used in Malaysian traditional medicine for the treatment of tumour cells. This is the frst report on the use of P. minus as an HIV-1 protease inhibitor. |
| format |
Article |
| author |
Ahmad, Rafidah Sahidin, I. Bakhtiar, M. Taher Low, Chen Fei Mohd Noor, Normah Sillapachaiyaporn, Chanin Chuchawankul, Siriporn Sarachana, Tewarit Tencomnao, Tewin Iskandar, Faizah Rajab, Nor Fadilah Baharum, Syarul Nataqain |
| author_facet |
Ahmad, Rafidah Sahidin, I. Bakhtiar, M. Taher Low, Chen Fei Mohd Noor, Normah Sillapachaiyaporn, Chanin Chuchawankul, Siriporn Sarachana, Tewarit Tencomnao, Tewin Iskandar, Faizah Rajab, Nor Fadilah Baharum, Syarul Nataqain |
| author_sort |
Ahmad, Rafidah |
| title |
Polygonumins A, a newly isolated compound from the stem of
Polygonum minus Huds with potential medicinal activities |
| title_short |
Polygonumins A, a newly isolated compound from the stem of
Polygonum minus Huds with potential medicinal activities |
| title_full |
Polygonumins A, a newly isolated compound from the stem of
Polygonum minus Huds with potential medicinal activities |
| title_fullStr |
Polygonumins A, a newly isolated compound from the stem of
Polygonum minus Huds with potential medicinal activities |
| title_full_unstemmed |
Polygonumins A, a newly isolated compound from the stem of
Polygonum minus Huds with potential medicinal activities |
| title_sort |
polygonumins a, a newly isolated compound from the stem of
polygonum minus huds with potential medicinal activities |
| publisher |
Nature Publishing Group |
| publishDate |
2018 |
| url |
http://irep.iium.edu.my/62635/ http://irep.iium.edu.my/62635/ http://irep.iium.edu.my/62635/ http://irep.iium.edu.my/62635/7/62635%20Polygonumins%20A%2C%20a%20newly%20isolated%20SCOPUS.pdf http://irep.iium.edu.my/62635/13/62635_Polygonumins%20A%2C%20a%20newly%20isolated%20compound.pdf http://irep.iium.edu.my/62635/14/62635_Polygonumins%20A%2C%20a%20newly%20isolated%20compound_WOS.pdf |
| first_indexed |
2023-09-18T21:28:45Z |
| last_indexed |
2023-09-18T21:28:45Z |
| _version_ |
1777412368596205568 |