Screening of fatty acid compound of S. polycystum for anti-cariogenic potential

Introduction: Dental caries is the most common yet preventable disease. Study found that seaweed exhibits anti-cariogenic properties. However, little attention have been given to the study on anticariogenic properties of seaweed and the bioactive compound that responsible for the anticariogenic act...

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Main Authors:	Zamimi, Nurul Najwa, Ab. Halim, Noorhazayti, Lestari, Widya, Darnis, Deny Susanti, Md Mustafa, Md Muziman Syah, Wan Ishak, Wan Mohd Faizal
Format:	Article
Language:	English
Published:	International Medical Journal Malaysia 2017
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/62599/ http://irep.iium.edu.my/62599/ http://irep.iium.edu.my/62599/1/62599_Screening%20Of%20Fatty%20Acid%20Compound.pdf

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recordtype	eprints
spelling	iium-625992020-02-26T15:15:23Z http://irep.iium.edu.my/62599/ Screening of fatty acid compound of S. polycystum for anti-cariogenic potential Zamimi, Nurul Najwa Ab. Halim, Noorhazayti Lestari, Widya Darnis, Deny Susanti Md Mustafa, Md Muziman Syah Wan Ishak, Wan Mohd Faizal RK Dentistry Introduction: Dental caries is the most common yet preventable disease. Study found that seaweed exhibits anti-cariogenic properties. However, little attention have been given to the study on anticariogenic properties of seaweed and the bioactive compound that responsible for the anticariogenic activities have not adequately investigated. This study was conducted to evaluate the best extraction methods for S. polycystum and to determine the fatty acid compounds of S. polycystum that have anti-cariogenic potential against oral cariogenic bacteria. Materials and Methods: Dried seaweeds were extracted by soxhlet using three different solvents (methanol, dichloromethane and hexane). The crude extracts were kept in a close container at -20 degree Celsius. The bioactive compound of the crude extract of seaweeds was analyzed using Gas Chromatography Mass Spectrometer (GCMS). Results: Highest extraction yield in S. polycystum was produced by methanol extraction followed by hexane and dichloromethane. GCMS analysis revealed that the presence of palmitic acid (18.02%) as major compound, followed by oleic acid (8.44%), lauric acid (5.23%), myristic acid (3.60%), heptadecanoic acid (2.23%), 9-hexadenoic acid (1.82%) and the lowest is 2-methylhexadecan-1-ol (1.75%). Conclusion(s): Methanol extraction is the most efficient solvent as it produced the highest extraction yield in S. polycystum.Lauric acid, palmitic acid, myristic acid and oleic acid detected in S. polycystum have been reported to exhibit antimicrobial activities thus proved the potentiality of S. polycystum as anti-cariogenic agent. International Medical Journal Malaysia 2017-11-13 Article PeerReviewed application/pdf en http://irep.iium.edu.my/62599/1/62599_Screening%20Of%20Fatty%20Acid%20Compound.pdf Zamimi, Nurul Najwa and Ab. Halim, Noorhazayti and Lestari, Widya and Darnis, Deny Susanti and Md Mustafa, Md Muziman Syah and Wan Ishak, Wan Mohd Faizal (2017) Screening of fatty acid compound of S. polycystum for anti-cariogenic potential. International Medical Journal Malaysia (IMJM), 16 (Supp. 2). p. 1. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/volume-16-supplementary-issue-no-2/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RK Dentistry
spellingShingle	RK Dentistry Zamimi, Nurul Najwa Ab. Halim, Noorhazayti Lestari, Widya Darnis, Deny Susanti Md Mustafa, Md Muziman Syah Wan Ishak, Wan Mohd Faizal Screening of fatty acid compound of S. polycystum for anti-cariogenic potential
description	Introduction: Dental caries is the most common yet preventable disease. Study found that seaweed exhibits anti-cariogenic properties. However, little attention have been given to the study on anticariogenic properties of seaweed and the bioactive compound that responsible for the anticariogenic activities have not adequately investigated. This study was conducted to evaluate the best extraction methods for S. polycystum and to determine the fatty acid compounds of S. polycystum that have anti-cariogenic potential against oral cariogenic bacteria. Materials and Methods: Dried seaweeds were extracted by soxhlet using three different solvents (methanol, dichloromethane and hexane). The crude extracts were kept in a close container at -20 degree Celsius. The bioactive compound of the crude extract of seaweeds was analyzed using Gas Chromatography Mass Spectrometer (GCMS). Results: Highest extraction yield in S. polycystum was produced by methanol extraction followed by hexane and dichloromethane. GCMS analysis revealed that the presence of palmitic acid (18.02%) as major compound, followed by oleic acid (8.44%), lauric acid (5.23%), myristic acid (3.60%), heptadecanoic acid (2.23%), 9-hexadenoic acid (1.82%) and the lowest is 2-methylhexadecan-1-ol (1.75%). Conclusion(s): Methanol extraction is the most efficient solvent as it produced the highest extraction yield in S. polycystum.Lauric acid, palmitic acid, myristic acid and oleic acid detected in S. polycystum have been reported to exhibit antimicrobial activities thus proved the potentiality of S. polycystum as anti-cariogenic agent.
format	Article
author	Zamimi, Nurul Najwa Ab. Halim, Noorhazayti Lestari, Widya Darnis, Deny Susanti Md Mustafa, Md Muziman Syah Wan Ishak, Wan Mohd Faizal
author_facet	Zamimi, Nurul Najwa Ab. Halim, Noorhazayti Lestari, Widya Darnis, Deny Susanti Md Mustafa, Md Muziman Syah Wan Ishak, Wan Mohd Faizal
author_sort	Zamimi, Nurul Najwa
title	Screening of fatty acid compound of S. polycystum for anti-cariogenic potential
title_short	Screening of fatty acid compound of S. polycystum for anti-cariogenic potential
title_full	Screening of fatty acid compound of S. polycystum for anti-cariogenic potential
title_fullStr	Screening of fatty acid compound of S. polycystum for anti-cariogenic potential
title_full_unstemmed	Screening of fatty acid compound of S. polycystum for anti-cariogenic potential
title_sort	screening of fatty acid compound of s. polycystum for anti-cariogenic potential
publisher	International Medical Journal Malaysia
publishDate	2017
url	http://irep.iium.edu.my/62599/ http://irep.iium.edu.my/62599/ http://irep.iium.edu.my/62599/1/62599_Screening%20Of%20Fatty%20Acid%20Compound.pdf
first_indexed	2023-09-18T21:28:42Z
last_indexed	2023-09-18T21:28:42Z
_version_	1777412365359251456

Screening of fatty acid compound of S. polycystum for anti-cariogenic potential

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