Animal models and natural products to investigate in vivo and in vitro antidiabetic activity
Diabetes mellitus is a chronic disease which has high prevalence. The deficiency in insulin production or impaired insulin function is the underlying cause of this disease. Utilization of plant sources as a cure of diabetes has rich evidence in the history. Recently, the traditional medicinal plants...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Elsevier
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/62580/ http://irep.iium.edu.my/62580/ http://irep.iium.edu.my/62580/ http://irep.iium.edu.my/62580/1/62580_Animal%20models%20and%20natural%20products%20to%20investigate%20in%20vivo%20and%20in%20vitro.pdf http://irep.iium.edu.my/62580/7/62580_Animal%20models%20and%20natural%20products%20to%20investigate_SCOPUS.pdf http://irep.iium.edu.my/62580/8/62580_Animal%20models%20and%20natural%20products%20to%20investigate_WOS.pdf |
| Summary: | Diabetes mellitus is a chronic disease which has high prevalence. The deficiency in insulin production or impaired insulin function is the underlying cause of this disease. Utilization of plant sources as a cure of diabetes has rich evidence in the history. Recently, the traditional medicinal plants have been investigated scientifically to understand the underlying mechanism behind antidiabetic potential. In this regard, a substantial number of in vivo and in vitro models have been introduced for investigating the bottom-line mechanism of the antidiabetic effect. A good number of methods have been reported to be used successfully to determine antidiabetic effects of plant extracts or isolated compounds. This review encompasses all the possible methods with a list of medicinal plants which may contribute to discovering a novel drug to treat diabetes more efficaciously with the minimum or no side effects. |
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