Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation

Gliclazide tablet is widely used for the treatment of non-insulin-dependent diabetes mellitus. However, there is still lack of study done in formulating the sustained release gliclazide tablet. Combination of xanthan gum, a natural gum and hydroxypropyl methylcellulose (HPMC) were used to act as ret...

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Main Authors:	Othman, Liyana Zafirah, Mohd Nawi, Mohamed Sufian, Abul Bashar Mohammed, Helaluddin, Elsayed, Tarek Mohamed Ali
Format:	Conference or Workshop Item
Language:	English
Published:	2017
Subjects:	RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/62416/ http://irep.iium.edu.my/62416/1/Cover%20and%20abstract%20_IMFSC%202017.pdf

id	iium-62416
recordtype	eprints
spelling	iium-624162018-03-29T01:43:23Z http://irep.iium.edu.my/62416/ Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation Othman, Liyana Zafirah Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Elsayed, Tarek Mohamed Ali RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Gliclazide tablet is widely used for the treatment of non-insulin-dependent diabetes mellitus. However, there is still lack of study done in formulating the sustained release gliclazide tablet. Combination of xanthan gum, a natural gum and hydroxypropyl methylcellulose (HPMC) were used to act as retardants for the sustained release gliclazide tablet. In this study, sustained release 60 mg gliclazide tablets were formulated with different ratios and content of xanthan gum and HPMC. The tablets were produced by wet granulation and semi-automatic tableting process. The content variation, weight variation, hardness, and friability of the tablet met the specification by British Pharmacopoeia. In vitro dissolution profiles of the tablets were compared with the commercially available sustained release 60 mg gliclazide tablet. Keywords: Gliclazide; sustained release; xanthan gum; HPMC 2017 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/62416/1/Cover%20and%20abstract%20_IMFSC%202017.pdf Othman, Liyana Zafirah and Mohd Nawi, Mohamed Sufian and Abul Bashar Mohammed, Helaluddin and Elsayed, Tarek Mohamed Ali (2017) Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation. In: International Malaysian French Scientific Conference 2017, 18th-19th December 2017, Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Othman, Liyana Zafirah Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Elsayed, Tarek Mohamed Ali Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation
description	Gliclazide tablet is widely used for the treatment of non-insulin-dependent diabetes mellitus. However, there is still lack of study done in formulating the sustained release gliclazide tablet. Combination of xanthan gum, a natural gum and hydroxypropyl methylcellulose (HPMC) were used to act as retardants for the sustained release gliclazide tablet. In this study, sustained release 60 mg gliclazide tablets were formulated with different ratios and content of xanthan gum and HPMC. The tablets were produced by wet granulation and semi-automatic tableting process. The content variation, weight variation, hardness, and friability of the tablet met the specification by British Pharmacopoeia. In vitro dissolution profiles of the tablets were compared with the commercially available sustained release 60 mg gliclazide tablet. Keywords: Gliclazide; sustained release; xanthan gum; HPMC
format	Conference or Workshop Item
author	Othman, Liyana Zafirah Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Elsayed, Tarek Mohamed Ali
author_facet	Othman, Liyana Zafirah Mohd Nawi, Mohamed Sufian Abul Bashar Mohammed, Helaluddin Elsayed, Tarek Mohamed Ali
author_sort	Othman, Liyana Zafirah
title	Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation
title_short	Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation
title_full	Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation
title_fullStr	Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation
title_full_unstemmed	Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation
title_sort	combination of xanthan gum and hpmc as retardants in sustained release gliclazide formulation
publishDate	2017
url	http://irep.iium.edu.my/62416/ http://irep.iium.edu.my/62416/1/Cover%20and%20abstract%20_IMFSC%202017.pdf
first_indexed	2023-09-18T21:28:27Z
last_indexed	2023-09-18T21:28:27Z
_version_	1777412349676748800

Combination of xanthan gum and HPMC as retardants in sustained release gliclazide formulation

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