Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan

Lupus nephritis (LN) is a serious complication of systemic lupus erythematous (SLE) and the possible risk factors for the disease progression are not very well understood. In this study we aimed to determine the response to treatment and identify the potential risk factors associated with the respon...

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Main Authors:	Mohd Zainuddin, Mohammad Nuriman, Ramli, Norazsida, Seman, Mohd Ramli
Format:	Conference or Workshop Item
Language:	English English
Published:	2017
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/62231/ http://irep.iium.edu.my/62231/17/62231-Risk%20factors%20and%20outcomes%20of%20SLE%20patients.pdf http://irep.iium.edu.my/62231/1/poster%20iman%20sympobiomed2017.pdf

id	iium-62231
recordtype	eprints
spelling	iium-622312018-03-02T08:49:16Z http://irep.iium.edu.my/62231/ Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan Mohd Zainuddin, Mohammad Nuriman Ramli, Norazsida Seman, Mohd Ramli RC Internal medicine Lupus nephritis (LN) is a serious complication of systemic lupus erythematous (SLE) and the possible risk factors for the disease progression are not very well understood. In this study we aimed to determine the response to treatment and identify the potential risk factors associated with the response. A hospital record review and single centre study has been carried out that includes patients with Class III, IV and V LN, who underwent renal biopsy and were treated at Department of Nephrology, HTAA for at least one year. Secondary data from patients' medical record such as demographic data; gender, race, and clinical data; proteinuria, serum creatinine, comorbidities and type of treatment were collected as the independent risk factors. Out of 54 patients of LN, 19 patients (35.2%) were classified under Class III/ III+V LN, 28 patients (51.9%) Class IV/ IV+V LN and seven patients (13%) Class V LN. Response to induction treatment showed six patients (11.1%) had no response, 23 patients (42.6%) had complete remission and 25 patients (46.3%) with partial remission. Hypoalbuminemia and anaemia were identified as the potential risk factors associated with the response to induction treatment (p = 0.045) and (p = 0.016) respectively. Besides, other factors like gender, race, serum creatinine, comorbidities and type of treatment were not significantly associated with the response towards treatment. In conclusion, only hypoalbuminemia and anaemia associated with the response of the treatment. The treatment provided was considered as effective since only 6 cases of patients did not respond to treatment throughout the 54 cases reviewed. 2017-05 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/62231/17/62231-Risk%20factors%20and%20outcomes%20of%20SLE%20patients.pdf application/pdf en http://irep.iium.edu.my/62231/1/poster%20iman%20sympobiomed2017.pdf Mohd Zainuddin, Mohammad Nuriman and Ramli, Norazsida and Seman, Mohd Ramli (2017) Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan. In: 8th Malaysian Symposium of Biomedical Science, 12th-14th May 2017, Kuantan, Pahang. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Mohd Zainuddin, Mohammad Nuriman Ramli, Norazsida Seman, Mohd Ramli Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan
description	Lupus nephritis (LN) is a serious complication of systemic lupus erythematous (SLE) and the possible risk factors for the disease progression are not very well understood. In this study we aimed to determine the response to treatment and identify the potential risk factors associated with the response. A hospital record review and single centre study has been carried out that includes patients with Class III, IV and V LN, who underwent renal biopsy and were treated at Department of Nephrology, HTAA for at least one year. Secondary data from patients' medical record such as demographic data; gender, race, and clinical data; proteinuria, serum creatinine, comorbidities and type of treatment were collected as the independent risk factors. Out of 54 patients of LN, 19 patients (35.2%) were classified under Class III/ III+V LN, 28 patients (51.9%) Class IV/ IV+V LN and seven patients (13%) Class V LN. Response to induction treatment showed six patients (11.1%) had no response, 23 patients (42.6%) had complete remission and 25 patients (46.3%) with partial remission. Hypoalbuminemia and anaemia were identified as the potential risk factors associated with the response to induction treatment (p = 0.045) and (p = 0.016) respectively. Besides, other factors like gender, race, serum creatinine, comorbidities and type of treatment were not significantly associated with the response towards treatment. In conclusion, only hypoalbuminemia and anaemia associated with the response of the treatment. The treatment provided was considered as effective since only 6 cases of patients did not respond to treatment throughout the 54 cases reviewed.
format	Conference or Workshop Item
author	Mohd Zainuddin, Mohammad Nuriman Ramli, Norazsida Seman, Mohd Ramli
author_facet	Mohd Zainuddin, Mohammad Nuriman Ramli, Norazsida Seman, Mohd Ramli
author_sort	Mohd Zainuddin, Mohammad Nuriman
title	Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan
title_short	Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan
title_full	Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan
title_fullStr	Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan
title_full_unstemmed	Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan
title_sort	risk factors and outcomes of sle patients with lupus nephritis class iii, iv and v treated at hospital tengku ampuan afzan, kuantan
publishDate	2017
url	http://irep.iium.edu.my/62231/ http://irep.iium.edu.my/62231/17/62231-Risk%20factors%20and%20outcomes%20of%20SLE%20patients.pdf http://irep.iium.edu.my/62231/1/poster%20iman%20sympobiomed2017.pdf
first_indexed	2023-09-18T21:28:14Z
last_indexed	2023-09-18T21:28:14Z
_version_	1777412335549284352

Risk factors and outcomes of SLE Patients with Lupus Nephritis Class III, IV and V treated at Hospital Tengku Ampuan Afzan, Kuantan

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